Exploring the Dynamic Interplay of Deleterious Variants on the RAF1–RAP1A Binding in Cancer: Conformational Analysis, Binding Free Energy, and Essential Dynamics

Exploring the Dynamic Interplay of Deleterious Variants on the RAF1–RAP1A Binding in Cancer: Conformational Analysis, Binding Free Energy, and Essential Dynamics

<p dir="ltr">The RAF1–RAP1A interaction activates the MAPK/ERK pathway which is very crucial in the carcinogenesis process. This protein complex influences tumor formation, proliferation, and metastasis. Understanding aberrant interactions driven by clinical mutations is vital for ta...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Abbas Khan (5141000) (author)
مؤلفون آخرون: Syed Shujait Ali (5159288) (author), Muhammad Ammar Zahid (18123775) (author), Shahenda Salah Abdelsalam (22330768) (author), Noorah Albekairi (22330771) (author), Raed M. Al‐Zoubi (21348629) (author), Mohanad Shkoor (3768385) (author), Dong‐Qing Wei (22330774) (author), Abdelali Agouni (181926) (author)
منشور في: 2024
الموضوعات:
Biological sciences
Bioinformatics and computational biology
Biomedical and clinical sciences
Oncology and carcinogenesis
binding free energy
cancer
docking
MAPK
mutations
RAF1
simulation
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