Exploring the Dynamic Interplay of Deleterious Variants on the RAF1–RAP1A Binding in Cancer: Conformational Analysis, Binding Free Energy, and Essential Dynamics

<p dir="ltr">The RAF1–RAP1A interaction activates the MAPK/ERK pathway which is very crucial in the carcinogenesis process. This protein complex influences tumor formation, proliferation, and metastasis. Understanding aberrant interactions driven by clinical mutations is vital for ta...

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Bibliographic Details
Main Author:	Abbas Khan (5141000) (author)
Other Authors:	Syed Shujait Ali (5159288) (author), Muhammad Ammar Zahid (18123775) (author), Shahenda Salah Abdelsalam (22330768) (author), Noorah Albekairi (22330771) (author), Raed M. Al‐Zoubi (21348629) (author), Mohanad Shkoor (3768385) (author), Dong‐Qing Wei (22330774) (author), Abdelali Agouni (181926) (author)
Published:	2024
Subjects:	Biological sciences Bioinformatics and computational biology Biomedical and clinical sciences Oncology and carcinogenesis binding free energy cancer docking MAPK mutations RAF1 simulation
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Exploring the Dynamic Interplay of Deleterious Variants on the RAF1–RAP1A Binding in Cancer: Conformational Analysis, Binding Free Energy, and Essential Dynamics

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