Early‐Life Sugar Consumption Affects the Microbiome in Juvenile Mice
<p></p><div> <h3> Scope</h3> <p>The composition of the gut microbiota is influenced by the dietary nutrient. Sugar has been linked with many metabolic health disorders such as heart disease, metabolic syndrome, and immune disorders. Long-term consumption of sugar...
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| مؤلفون آخرون: | , , |
| منشور في: |
2023
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| _version_ | 1864513565232201728 |
|---|---|
| author | Reem Moath Alasmar (14778949) |
| author2 | Kavitha Varadharajan (14778952) Muralitharan Shanmugakonar (14778955) Hamda A. Al‐Naemi (14778958) |
| author2_role | author author author |
| author_facet | Reem Moath Alasmar (14778949) Kavitha Varadharajan (14778952) Muralitharan Shanmugakonar (14778955) Hamda A. Al‐Naemi (14778958) |
| author_role | author |
| dc.creator.none.fl_str_mv | Reem Moath Alasmar (14778949) Kavitha Varadharajan (14778952) Muralitharan Shanmugakonar (14778955) Hamda A. Al‐Naemi (14778958) |
| dc.date.none.fl_str_mv | 2023-03-16T06:24:09Z |
| dc.identifier.none.fl_str_mv | 10.1002/mnfr.202200322 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Early_Life_Sugar_Consumption_Affects_the_Microbiome_in_Juvenile_Mice/22258282 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Agricultural, veterinary and food sciences Food sciences Food Science Biotechnology |
| dc.title.none.fl_str_mv | Early‐Life Sugar Consumption Affects the Microbiome in Juvenile Mice |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p></p><div> <h3> Scope</h3> <p>The composition of the gut microbiota is influenced by the dietary nutrient. Sugar has been linked with many metabolic health disorders such as heart disease, metabolic syndrome, and immune disorders. Long-term consumption of sugar influences the landscape of gut microbiota by altering the gut microbial population called dysbiosis. This study aims to evaluate the impact of long-term consumption of high sugar diet (HSD) on the diversity of gut microbiota.</p> <h3> Methods and results</h3> <p>CD1 mice are given high concentration of sugar for 15 weeks followed by a recovery period of 10 weeks. Real-time polymerase chain reaction and 16S rRNA next-generation sequencing methods employ to identify microbiome diversity. The results show that <i>Firmicutes</i> and <i>Bacteroidetes</i> are the predominant phyla in control, cecum, and fecal samples. <i>Firmicutes</i> population are gradually increased in treated samples even after the recovery period, whereas <i>Bacteroidetes</i> abundance slightly reduces throughout the study.</p> <h3> Conclusion</h3> <p>The present study shows that the impact of long period of high sugar diet consumption alters the diversity of normal gut flora which can be restored after 10 weeks of sugar withdrawal. This indicates that the intervention of healthy and nutritious diet influences gut microbes and this can be beneficial in reducing the implication of early life metabolic disorders such as obesity.</p> </div><p></p><h2>Other Information</h2> <p> Published in: Molecular Nutrition & Food Research<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1002/mnfr.202200322" target="_blank">http://dx.doi.org/10.1002/mnfr.202200322</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_c35ec8eb4cec7a6106b1ed1d7f632c9f |
| identifier_str_mv | 10.1002/mnfr.202200322 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22258282 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Early‐Life Sugar Consumption Affects the Microbiome in Juvenile MiceReem Moath Alasmar (14778949)Kavitha Varadharajan (14778952)Muralitharan Shanmugakonar (14778955)Hamda A. Al‐Naemi (14778958)Agricultural, veterinary and food sciencesFood sciencesFood ScienceBiotechnology<p></p><div> <h3> Scope</h3> <p>The composition of the gut microbiota is influenced by the dietary nutrient. Sugar has been linked with many metabolic health disorders such as heart disease, metabolic syndrome, and immune disorders. Long-term consumption of sugar influences the landscape of gut microbiota by altering the gut microbial population called dysbiosis. This study aims to evaluate the impact of long-term consumption of high sugar diet (HSD) on the diversity of gut microbiota.</p> <h3> Methods and results</h3> <p>CD1 mice are given high concentration of sugar for 15 weeks followed by a recovery period of 10 weeks. Real-time polymerase chain reaction and 16S rRNA next-generation sequencing methods employ to identify microbiome diversity. The results show that <i>Firmicutes</i> and <i>Bacteroidetes</i> are the predominant phyla in control, cecum, and fecal samples. <i>Firmicutes</i> population are gradually increased in treated samples even after the recovery period, whereas <i>Bacteroidetes</i> abundance slightly reduces throughout the study.</p> <h3> Conclusion</h3> <p>The present study shows that the impact of long period of high sugar diet consumption alters the diversity of normal gut flora which can be restored after 10 weeks of sugar withdrawal. This indicates that the intervention of healthy and nutritious diet influences gut microbes and this can be beneficial in reducing the implication of early life metabolic disorders such as obesity.</p> </div><p></p><h2>Other Information</h2> <p> Published in: Molecular Nutrition & Food Research<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1002/mnfr.202200322" target="_blank">http://dx.doi.org/10.1002/mnfr.202200322</a></p>2023-03-16T06:24:09ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/mnfr.202200322https://figshare.com/articles/journal_contribution/Early_Life_Sugar_Consumption_Affects_the_Microbiome_in_Juvenile_Mice/22258282CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/222582822023-03-16T06:24:09Z |
| spellingShingle | Early‐Life Sugar Consumption Affects the Microbiome in Juvenile Mice Reem Moath Alasmar (14778949) Agricultural, veterinary and food sciences Food sciences Food Science Biotechnology |
| status_str | publishedVersion |
| title | Early‐Life Sugar Consumption Affects the Microbiome in Juvenile Mice |
| title_full | Early‐Life Sugar Consumption Affects the Microbiome in Juvenile Mice |
| title_fullStr | Early‐Life Sugar Consumption Affects the Microbiome in Juvenile Mice |
| title_full_unstemmed | Early‐Life Sugar Consumption Affects the Microbiome in Juvenile Mice |
| title_short | Early‐Life Sugar Consumption Affects the Microbiome in Juvenile Mice |
| title_sort | Early‐Life Sugar Consumption Affects the Microbiome in Juvenile Mice |
| topic | Agricultural, veterinary and food sciences Food sciences Food Science Biotechnology |