Extracellular vesicles as tools and targets in therapy for diseases
<p dir="ltr">Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously released from cells under normal and pathological conditions. Human serum is a rich so...
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| مؤلفون آخرون: | , , , , , , , , , , , , |
| منشور في: |
2024
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| _version_ | 1864513545558818816 |
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| author | Mudasir A. Kumar (21633080) |
| author2 | Sadaf K. Baba (21633083) Hana Q. Sadida (15376385) Sara Al. Marzooqi (21633086) Jayakumar Jerobin (6595520) Faisal H. Altemani (17723992) Naseh Algehainy (21633089) Mohammad A. Alanazi (20849476) Abdul-Badi Abou-Samra (3411167) Rakesh Kumar (8432) Ammira S. Al-Shabeeb Akil (18206017) Muzafar A. Macha (11605200) Rashid Mir (2616949) Ajaz A. Bhat (12984701) |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Mudasir A. Kumar (21633080) Sadaf K. Baba (21633083) Hana Q. Sadida (15376385) Sara Al. Marzooqi (21633086) Jayakumar Jerobin (6595520) Faisal H. Altemani (17723992) Naseh Algehainy (21633089) Mohammad A. Alanazi (20849476) Abdul-Badi Abou-Samra (3411167) Rakesh Kumar (8432) Ammira S. Al-Shabeeb Akil (18206017) Muzafar A. Macha (11605200) Rashid Mir (2616949) Ajaz A. Bhat (12984701) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mudasir A. Kumar (21633080) Sadaf K. Baba (21633083) Hana Q. Sadida (15376385) Sara Al. Marzooqi (21633086) Jayakumar Jerobin (6595520) Faisal H. Altemani (17723992) Naseh Algehainy (21633089) Mohammad A. Alanazi (20849476) Abdul-Badi Abou-Samra (3411167) Rakesh Kumar (8432) Ammira S. Al-Shabeeb Akil (18206017) Muzafar A. Macha (11605200) Rashid Mir (2616949) Ajaz A. Bhat (12984701) |
| dc.date.none.fl_str_mv | 2024-02-05T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41392-024-01735-1 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Extracellular_vesicles_as_tools_and_targets_in_therapy_for_diseases/29445614 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Medical biotechnology Pharmacology and pharmaceutical sciences Extracellular vesicles (EVs) Liquid biopsy Cancer diagnostics Tumor microenvironment (TME) Biomarkers Drug delivery systems |
| dc.title.none.fl_str_mv | Extracellular vesicles as tools and targets in therapy for diseases |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously released from cells under normal and pathological conditions. Human serum is a rich source of these EVs, though their isolation from serum proteins and non-EV lipid particles poses challenges. These vesicles transport various cellular components such as proteins, mRNAs, miRNAs, DNA, and lipids across distances, influencing numerous physiological and pathological events, including those within the tumor microenvironment (TME). Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents, drug delivery systems, and disease biomarkers. Especially in cancer diagnostics, EV detection can pave the way for early identification and offers potential as diagnostic biomarkers. Moreover, various EV subtypes are emerging as targeted drug delivery tools, highlighting their potential clinical significance. The need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains unfulfilled. Tapping into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the future. In this review, we discuss in detail the roles of EVs across various conditions, including cancers (encompassing head and neck, lung, gastric, breast, and hepatocellular carcinoma), neurodegenerative disorders, diabetes, viral infections, autoimmune and renal diseases, emphasizing the potential advancements in molecular diagnostics and drug delivery.</p><h2>Other Information</h2><p dir="ltr">Published in: Signal Transduction and Targeted Therapy<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41392-024-01735-1" target="_blank">https://dx.doi.org/10.1038/s41392-024-01735-1</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_c3b72b0cfa8b13ef474491dc19920e78 |
| identifier_str_mv | 10.1038/s41392-024-01735-1 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29445614 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Extracellular vesicles as tools and targets in therapy for diseasesMudasir A. Kumar (21633080)Sadaf K. Baba (21633083)Hana Q. Sadida (15376385)Sara Al. Marzooqi (21633086)Jayakumar Jerobin (6595520)Faisal H. Altemani (17723992)Naseh Algehainy (21633089)Mohammad A. Alanazi (20849476)Abdul-Badi Abou-Samra (3411167)Rakesh Kumar (8432)Ammira S. Al-Shabeeb Akil (18206017)Muzafar A. Macha (11605200)Rashid Mir (2616949)Ajaz A. Bhat (12984701)Biomedical and clinical sciencesMedical biochemistry and metabolomicsMedical biotechnologyPharmacology and pharmaceutical sciencesExtracellular vesicles (EVs)Liquid biopsyCancer diagnosticsTumor microenvironment (TME)BiomarkersDrug delivery systems<p dir="ltr">Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously released from cells under normal and pathological conditions. Human serum is a rich source of these EVs, though their isolation from serum proteins and non-EV lipid particles poses challenges. These vesicles transport various cellular components such as proteins, mRNAs, miRNAs, DNA, and lipids across distances, influencing numerous physiological and pathological events, including those within the tumor microenvironment (TME). Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents, drug delivery systems, and disease biomarkers. Especially in cancer diagnostics, EV detection can pave the way for early identification and offers potential as diagnostic biomarkers. Moreover, various EV subtypes are emerging as targeted drug delivery tools, highlighting their potential clinical significance. The need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains unfulfilled. Tapping into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the future. In this review, we discuss in detail the roles of EVs across various conditions, including cancers (encompassing head and neck, lung, gastric, breast, and hepatocellular carcinoma), neurodegenerative disorders, diabetes, viral infections, autoimmune and renal diseases, emphasizing the potential advancements in molecular diagnostics and drug delivery.</p><h2>Other Information</h2><p dir="ltr">Published in: Signal Transduction and Targeted Therapy<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41392-024-01735-1" target="_blank">https://dx.doi.org/10.1038/s41392-024-01735-1</a></p>2024-02-05T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41392-024-01735-1https://figshare.com/articles/journal_contribution/Extracellular_vesicles_as_tools_and_targets_in_therapy_for_diseases/29445614CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/294456142024-02-05T03:00:00Z |
| spellingShingle | Extracellular vesicles as tools and targets in therapy for diseases Mudasir A. Kumar (21633080) Biomedical and clinical sciences Medical biochemistry and metabolomics Medical biotechnology Pharmacology and pharmaceutical sciences Extracellular vesicles (EVs) Liquid biopsy Cancer diagnostics Tumor microenvironment (TME) Biomarkers Drug delivery systems |
| status_str | publishedVersion |
| title | Extracellular vesicles as tools and targets in therapy for diseases |
| title_full | Extracellular vesicles as tools and targets in therapy for diseases |
| title_fullStr | Extracellular vesicles as tools and targets in therapy for diseases |
| title_full_unstemmed | Extracellular vesicles as tools and targets in therapy for diseases |
| title_short | Extracellular vesicles as tools and targets in therapy for diseases |
| title_sort | Extracellular vesicles as tools and targets in therapy for diseases |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Medical biotechnology Pharmacology and pharmaceutical sciences Extracellular vesicles (EVs) Liquid biopsy Cancer diagnostics Tumor microenvironment (TME) Biomarkers Drug delivery systems |