Inflammatory protein signatures in individuals with obesity and metabolic syndrome
<p dir="ltr">There is variability in the metabolic health status among individuals presenting with obesity; some may be metabolically healthy, while others may have developed the metabolic syndrome, a cluster including insulin resistance, hypertension, dyslipidemia, and increased ris...
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2023
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| _version_ | 1864513507548987392 |
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| author | Fayaz Ahmad Mir (11828354) |
| author2 | Houari B. Abdesselem (14152827) Farhan Cyprian (12829466) Ahmad Iskandarani (3520067) Asmma Doudin (11828348) Tareq A. Samra (9440765) Meis Alkasem (9440768) Ibrahem Abdalhakam (13134576) Shahrad Taheri (57360) Abdul-Badi Abou-Samra (3411167) |
| author2_role | author author author author author author author author author |
| author_facet | Fayaz Ahmad Mir (11828354) Houari B. Abdesselem (14152827) Farhan Cyprian (12829466) Ahmad Iskandarani (3520067) Asmma Doudin (11828348) Tareq A. Samra (9440765) Meis Alkasem (9440768) Ibrahem Abdalhakam (13134576) Shahrad Taheri (57360) Abdul-Badi Abou-Samra (3411167) |
| author_role | author |
| dc.creator.none.fl_str_mv | Fayaz Ahmad Mir (11828354) Houari B. Abdesselem (14152827) Farhan Cyprian (12829466) Ahmad Iskandarani (3520067) Asmma Doudin (11828348) Tareq A. Samra (9440765) Meis Alkasem (9440768) Ibrahem Abdalhakam (13134576) Shahrad Taheri (57360) Abdul-Badi Abou-Samra (3411167) |
| dc.date.none.fl_str_mv | 2023-12-13T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41598-023-49643-8 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Inflammatory_protein_signatures_in_individuals_with_obesity_and_metabolic_syndrome/26808031 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Medical biochemistry and metabolomics Obesity Metabolic Syndrome Metabolic Health Insulin Resistance Hypertension Dyslipidemia Cardiovascular Disease |
| dc.title.none.fl_str_mv | Inflammatory protein signatures in individuals with obesity and metabolic syndrome |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">There is variability in the metabolic health status among individuals presenting with obesity; some may be metabolically healthy, while others may have developed the metabolic syndrome, a cluster including insulin resistance, hypertension, dyslipidemia, and increased risk of cardiovascular disease and type 2 diabetes. The mechanisms contributing to this metabolic heterogeneity are not fully understood. To address this question, plasma samples from 48 individuals with BMI ≥ 35 kg/m<sup>2</sup> were examined (27 with and 21 without metabolic syndrome). Fasting plasma samples were subjected to Olink proteomics analysis for 184 cardiometabolic and inflammation-enriched proteins. Data analysis showed a clear differentiation between the two groups with distinct plasma protein expression profiles. Twenty-four proteins were differentially expressed (DEPs) between the two groups. Pathways related to immune cell migration, leukocyte chemotaxis, chemokine signaling, mucosal inflammatory response, tissue repair and remodeling were enriched in the group with metabolic syndrome. Functional analysis of DEPs revealed upregulation of 15 immunological pathways. The study identifies some of the pathways that are altered and reflect metabolic health in individuals with obesity. This provides valuable insights into some of the underlying mechanisms and can lead to identification of therapeutic targets to improve metabolic health in individuals with obesity.</p><h2>Other Information</h2><p dir="ltr">Published in: Scientific Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-023-49643-8" target="_blank">https://dx.doi.org/10.1038/s41598-023-49643-8</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_c41d7671520faaeec74c78a281e26890 |
| identifier_str_mv | 10.1038/s41598-023-49643-8 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26808031 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Inflammatory protein signatures in individuals with obesity and metabolic syndromeFayaz Ahmad Mir (11828354)Houari B. Abdesselem (14152827)Farhan Cyprian (12829466)Ahmad Iskandarani (3520067)Asmma Doudin (11828348)Tareq A. Samra (9440765)Meis Alkasem (9440768)Ibrahem Abdalhakam (13134576)Shahrad Taheri (57360)Abdul-Badi Abou-Samra (3411167)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesMedical biochemistry and metabolomicsObesityMetabolic SyndromeMetabolic HealthInsulin ResistanceHypertensionDyslipidemiaCardiovascular Disease<p dir="ltr">There is variability in the metabolic health status among individuals presenting with obesity; some may be metabolically healthy, while others may have developed the metabolic syndrome, a cluster including insulin resistance, hypertension, dyslipidemia, and increased risk of cardiovascular disease and type 2 diabetes. The mechanisms contributing to this metabolic heterogeneity are not fully understood. To address this question, plasma samples from 48 individuals with BMI ≥ 35 kg/m<sup>2</sup> were examined (27 with and 21 without metabolic syndrome). Fasting plasma samples were subjected to Olink proteomics analysis for 184 cardiometabolic and inflammation-enriched proteins. Data analysis showed a clear differentiation between the two groups with distinct plasma protein expression profiles. Twenty-four proteins were differentially expressed (DEPs) between the two groups. Pathways related to immune cell migration, leukocyte chemotaxis, chemokine signaling, mucosal inflammatory response, tissue repair and remodeling were enriched in the group with metabolic syndrome. Functional analysis of DEPs revealed upregulation of 15 immunological pathways. The study identifies some of the pathways that are altered and reflect metabolic health in individuals with obesity. This provides valuable insights into some of the underlying mechanisms and can lead to identification of therapeutic targets to improve metabolic health in individuals with obesity.</p><h2>Other Information</h2><p dir="ltr">Published in: Scientific Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-023-49643-8" target="_blank">https://dx.doi.org/10.1038/s41598-023-49643-8</a></p>2023-12-13T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41598-023-49643-8https://figshare.com/articles/journal_contribution/Inflammatory_protein_signatures_in_individuals_with_obesity_and_metabolic_syndrome/26808031CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/268080312023-12-13T09:00:00Z |
| spellingShingle | Inflammatory protein signatures in individuals with obesity and metabolic syndrome Fayaz Ahmad Mir (11828354) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Medical biochemistry and metabolomics Obesity Metabolic Syndrome Metabolic Health Insulin Resistance Hypertension Dyslipidemia Cardiovascular Disease |
| status_str | publishedVersion |
| title | Inflammatory protein signatures in individuals with obesity and metabolic syndrome |
| title_full | Inflammatory protein signatures in individuals with obesity and metabolic syndrome |
| title_fullStr | Inflammatory protein signatures in individuals with obesity and metabolic syndrome |
| title_full_unstemmed | Inflammatory protein signatures in individuals with obesity and metabolic syndrome |
| title_short | Inflammatory protein signatures in individuals with obesity and metabolic syndrome |
| title_sort | Inflammatory protein signatures in individuals with obesity and metabolic syndrome |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Medical biochemistry and metabolomics Obesity Metabolic Syndrome Metabolic Health Insulin Resistance Hypertension Dyslipidemia Cardiovascular Disease |