Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes
<p dir="ltr">The skin is the largest organ of the human body and prone to various diseases, including cancer; thus, provides the first line of defense against exogenous biological and non-biological agents. Skin cancer, a complex and heterogenic process, with steep incidence rate oft...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2022
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513541581570048 |
|---|---|
| author | Martin Steinhoff (5340194) |
| author2 | Majid Alam (14158959) Aamir Ahmad (233201) Shahab Uddin (154400) Joerg Buddenkotte (6293584) |
| author2_role | author author author author |
| author_facet | Martin Steinhoff (5340194) Majid Alam (14158959) Aamir Ahmad (233201) Shahab Uddin (154400) Joerg Buddenkotte (6293584) |
| author_role | author |
| dc.creator.none.fl_str_mv | Martin Steinhoff (5340194) Majid Alam (14158959) Aamir Ahmad (233201) Shahab Uddin (154400) Joerg Buddenkotte (6293584) |
| dc.date.none.fl_str_mv | 2022-12-01T21:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.semcancer.2022.11.009 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Targeting_oncogenic_transcription_factors_in_skin_malignancies_An_update_on_cancer_stemness_and_therapeutic_outcomes/24501175 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Transcription factors Bioactive natural products Skin malignancies Deregulated signaling Cancer stemness features |
| dc.title.none.fl_str_mv | Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The skin is the largest organ of the human body and prone to various diseases, including cancer; thus, provides the first line of defense against exogenous biological and non-biological agents. Skin cancer, a complex and heterogenic process, with steep incidence rate often metastasizes due to poor understanding of the underlying mechanisms of pathogenesis and clinical challenges. Indeed, accumulating evidence indicates that deregulation of transcription factors (TFs) due to genetic, epigenetic and signaling distortions plays essential role in the development of cutaneous malignancies and therapeutic challenges including cancer stemness features and reprogramming. This review highlights the recent developments exploring underlying mechanisms how deregulated TFs (e.g., NF-κB, AP-1, STAT etc.,) orchestrates cutaneous onco-pathogenesis, reprogramming, stemness and poor clinical outcomes. Along this line, bioactive drugs, and their derivatives from natural and or synthetic origin has gained attention due to their multitargeting potential, potentially safer and effective therapeutic outcome for human malignancies. We also discussed therapeutic importance of targeting aberrantly expressed TFs in skin cancers with bioactive natural products and or synthetic agents.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2022.11.009" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2022.11.009</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_c43f5fc7e4c3d94733395d5089367e54 |
| identifier_str_mv | 10.1016/j.semcancer.2022.11.009 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24501175 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomesMartin Steinhoff (5340194)Majid Alam (14158959)Aamir Ahmad (233201)Shahab Uddin (154400)Joerg Buddenkotte (6293584)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesClinical sciencesOncology and carcinogenesisTranscription factorsBioactive natural productsSkin malignanciesDeregulated signalingCancer stemness features<p dir="ltr">The skin is the largest organ of the human body and prone to various diseases, including cancer; thus, provides the first line of defense against exogenous biological and non-biological agents. Skin cancer, a complex and heterogenic process, with steep incidence rate often metastasizes due to poor understanding of the underlying mechanisms of pathogenesis and clinical challenges. Indeed, accumulating evidence indicates that deregulation of transcription factors (TFs) due to genetic, epigenetic and signaling distortions plays essential role in the development of cutaneous malignancies and therapeutic challenges including cancer stemness features and reprogramming. This review highlights the recent developments exploring underlying mechanisms how deregulated TFs (e.g., NF-κB, AP-1, STAT etc.,) orchestrates cutaneous onco-pathogenesis, reprogramming, stemness and poor clinical outcomes. Along this line, bioactive drugs, and their derivatives from natural and or synthetic origin has gained attention due to their multitargeting potential, potentially safer and effective therapeutic outcome for human malignancies. We also discussed therapeutic importance of targeting aberrantly expressed TFs in skin cancers with bioactive natural products and or synthetic agents.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2022.11.009" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2022.11.009</a></p>2022-12-01T21:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.semcancer.2022.11.009https://figshare.com/articles/journal_contribution/Targeting_oncogenic_transcription_factors_in_skin_malignancies_An_update_on_cancer_stemness_and_therapeutic_outcomes/24501175CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/245011752022-12-01T21:00:00Z |
| spellingShingle | Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes Martin Steinhoff (5340194) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Transcription factors Bioactive natural products Skin malignancies Deregulated signaling Cancer stemness features |
| status_str | publishedVersion |
| title | Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes |
| title_full | Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes |
| title_fullStr | Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes |
| title_full_unstemmed | Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes |
| title_short | Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes |
| title_sort | Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Transcription factors Bioactive natural products Skin malignancies Deregulated signaling Cancer stemness features |