PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells
<p dir="ltr">Cancer stem cells (CSCs) are a small subpopulation bearing self-renewal ability, mediating tumor initiation and propagation. Several molecular pathways, including the PI3K/AKT/mTOR pathway, are known to be aberrantly activated in cancers. In CSCs, PI3K/AKT/mTOR pathway h...
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2025
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| الموضوعات: | |
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| _version_ | 1864513533595615232 |
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| author | Kirti S. Prabhu (4246144) |
| author2 | Shilpa Kuttikrishnan (3520079) Zahwa Mariyam (22504034) Ummu Habeeba (22504037) Anu Jayanthi Panicker (22330129) Tariq Masoodi (8117702) Kulsoom Junejo (9327448) Shahab Uddin (154400) |
| author2_role | author author author author author author author |
| author_facet | Kirti S. Prabhu (4246144) Shilpa Kuttikrishnan (3520079) Zahwa Mariyam (22504034) Ummu Habeeba (22504037) Anu Jayanthi Panicker (22330129) Tariq Masoodi (8117702) Kulsoom Junejo (9327448) Shahab Uddin (154400) |
| author_role | author |
| dc.creator.none.fl_str_mv | Kirti S. Prabhu (4246144) Shilpa Kuttikrishnan (3520079) Zahwa Mariyam (22504034) Ummu Habeeba (22504037) Anu Jayanthi Panicker (22330129) Tariq Masoodi (8117702) Kulsoom Junejo (9327448) Shahab Uddin (154400) |
| dc.date.none.fl_str_mv | 2025-07-17T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00210-025-04297-3 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/PI3_K_AKT_mTOR_pathway_and_its_role_in_breast_cancer_stem_cells/30455789 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Breast cancer Cancer stem cells Epithelial–mesenchymal transition PI3/AKT/mTOR |
| dc.title.none.fl_str_mv | PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Cancer stem cells (CSCs) are a small subpopulation bearing self-renewal ability, mediating tumor initiation and propagation. Several molecular pathways, including the PI3K/AKT/mTOR pathway, are known to be aberrantly activated in cancers. In CSCs, PI3K/AKT/mTOR pathway has been associated with attribution of various properties to cancer cells including stemness characteristics, proliferation, migration, epithelial to mesenchymal transition, and autophagy. Thus, targeting PI3K/AKT/mTOR pathway with novel inhibitors might help to control the growth and proliferation of the breast CSC population. Though many studies have focused on PI3K/AKT/mTOR pathway in breast cancer, limited literature is available on the role of PI3K/AKT/mTOR pathway in breast CSCs. Here, in our present review, we have highlighted the role of the PI3K/AKT/mTOR signaling pathway in breast CSCs and its applications in therapeutic targeting.</p><h2>Other Information</h2><p dir="ltr">Published in: Naunyn-Schmiedeberg's Archives of Pharmacology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00210-025-04297-3" target="_blank">https://dx.doi.org/10.1007/s00210-025-04297-3</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_c5f4236e4c936d30ef5ebe1f4cb68c00 |
| identifier_str_mv | 10.1007/s00210-025-04297-3 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30455789 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | PI3 K/AKT/mTOR pathway and its role in breast cancer stem cellsKirti S. Prabhu (4246144)Shilpa Kuttikrishnan (3520079)Zahwa Mariyam (22504034)Ummu Habeeba (22504037)Anu Jayanthi Panicker (22330129)Tariq Masoodi (8117702)Kulsoom Junejo (9327448)Shahab Uddin (154400)Biomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesBreast cancerCancer stem cellsEpithelial–mesenchymal transitionPI3/AKT/mTOR<p dir="ltr">Cancer stem cells (CSCs) are a small subpopulation bearing self-renewal ability, mediating tumor initiation and propagation. Several molecular pathways, including the PI3K/AKT/mTOR pathway, are known to be aberrantly activated in cancers. In CSCs, PI3K/AKT/mTOR pathway has been associated with attribution of various properties to cancer cells including stemness characteristics, proliferation, migration, epithelial to mesenchymal transition, and autophagy. Thus, targeting PI3K/AKT/mTOR pathway with novel inhibitors might help to control the growth and proliferation of the breast CSC population. Though many studies have focused on PI3K/AKT/mTOR pathway in breast cancer, limited literature is available on the role of PI3K/AKT/mTOR pathway in breast CSCs. Here, in our present review, we have highlighted the role of the PI3K/AKT/mTOR signaling pathway in breast CSCs and its applications in therapeutic targeting.</p><h2>Other Information</h2><p dir="ltr">Published in: Naunyn-Schmiedeberg's Archives of Pharmacology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00210-025-04297-3" target="_blank">https://dx.doi.org/10.1007/s00210-025-04297-3</a></p>2025-07-17T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00210-025-04297-3https://figshare.com/articles/journal_contribution/PI3_K_AKT_mTOR_pathway_and_its_role_in_breast_cancer_stem_cells/30455789CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/304557892025-07-17T09:00:00Z |
| spellingShingle | PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells Kirti S. Prabhu (4246144) Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Breast cancer Cancer stem cells Epithelial–mesenchymal transition PI3/AKT/mTOR |
| status_str | publishedVersion |
| title | PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells |
| title_full | PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells |
| title_fullStr | PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells |
| title_full_unstemmed | PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells |
| title_short | PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells |
| title_sort | PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Breast cancer Cancer stem cells Epithelial–mesenchymal transition PI3/AKT/mTOR |