Genomic Instability in Hereditary Breast Cancer: Clinical and Nursing Implications for Risk Assessment and Targeted Therapeutic Strategies
<h3 dir="ltr">Objectives</h3><p dir="ltr">This review aims to bridge genomic insights with oncology nursing practice, promoting risk-informed care for patients with hereditary breast cancer (HBC). </p><h3 dir="ltr">Methods</h3><p d...
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2025
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| _version_ | 1864513531523629056 |
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| author | Aladeen Alloubani (19334490) |
| author2 | Refat Nimer (22927465) Fatima Farhan (22927468) Farah Eid (22927471) Yahya Khawaja (22927474) |
| author2_role | author author author author |
| author_facet | Aladeen Alloubani (19334490) Refat Nimer (22927465) Fatima Farhan (22927468) Farah Eid (22927471) Yahya Khawaja (22927474) |
| author_role | author |
| dc.creator.none.fl_str_mv | Aladeen Alloubani (19334490) Refat Nimer (22927465) Fatima Farhan (22927468) Farah Eid (22927471) Yahya Khawaja (22927474) |
| dc.date.none.fl_str_mv | 2025-11-09T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.soncn.2025.152054 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Genomic_Instability_in_Hereditary_Breast_Cancer_Clinical_and_Nursing_Implications_for_Risk_Assessment_and_Targeted_Therapeutic_Strategies/30970714 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Health sciences Nursing Public health Hereditary breast cancer Genetic risk assessment Genomic instability Oncology nursing Hallmarks of cancer |
| dc.title.none.fl_str_mv | Genomic Instability in Hereditary Breast Cancer: Clinical and Nursing Implications for Risk Assessment and Targeted Therapeutic Strategies |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3 dir="ltr">Objectives</h3><p dir="ltr">This review aims to bridge genomic insights with oncology nursing practice, promoting risk-informed care for patients with hereditary breast cancer (HBC). </p><h3 dir="ltr">Methods</h3><p dir="ltr">This study reviewed publications from 2018 to 2024, searching PubMed, CINAHL, and Cochrane under PRISMA guidelines. It systematically reviews GI, emphasizing sporadic and hereditary breast cancer (BC), including BRCA1/2-related hereditary breast and ovarian cancer syndrome (HBOC), Li-Fraumeni syndrome (TP53 mutations), and Lynch syndrome (MSI-driven BC). </p><h3 dir="ltr">Results</h3><p dir="ltr">Key genomic alterations such as TP53, BRCA1/2, and BCL2 mutations were found across various BC subtypes, including triple-negative, HER2-positive, and hormone receptor-positive tumors. Given the hereditary nature of some BC cases, genetic testing is crucial for risk assessment and early intervention, particularly as part of personalized screening protocols. Inhibiting these pathways with BCL2 inhibitors, PARP inhibitors for BRCA-mutated tumors, and immune checkpoint inhibitors for MSI-high tumors represents a promising therapeutic strategy. </p><h3 dir="ltr">Conclusions</h3><p dir="ltr">This review highlights the importance of integrating genomic findings into personalized care planning, genetic counseling, and patient education. </p><h3 dir="ltr">Implications for Nursing Practice</h3><p dir="ltr">Oncology nurses play a central role in applying genomic knowledge in patient care. They support informed decision-making regarding genetic testing, encourage adherence to surveillance protocols, monitor patients on targeted therapies, and advocate for equitable access to genetic services.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Seminars in Oncology Nursing<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.soncn.2025.152054" target="_blank">https://dx.doi.org/10.1016/j.soncn.2025.152054</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_c7bbc514f2dd8b4395649eac8afb1f36 |
| identifier_str_mv | 10.1016/j.soncn.2025.152054 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30970714 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Genomic Instability in Hereditary Breast Cancer: Clinical and Nursing Implications for Risk Assessment and Targeted Therapeutic StrategiesAladeen Alloubani (19334490)Refat Nimer (22927465)Fatima Farhan (22927468)Farah Eid (22927471)Yahya Khawaja (22927474)Biological sciencesGeneticsBiomedical and clinical sciencesOncology and carcinogenesisHealth sciencesNursingPublic healthHereditary breast cancerGenetic risk assessmentGenomic instabilityOncology nursingHallmarks of cancer<h3 dir="ltr">Objectives</h3><p dir="ltr">This review aims to bridge genomic insights with oncology nursing practice, promoting risk-informed care for patients with hereditary breast cancer (HBC). </p><h3 dir="ltr">Methods</h3><p dir="ltr">This study reviewed publications from 2018 to 2024, searching PubMed, CINAHL, and Cochrane under PRISMA guidelines. It systematically reviews GI, emphasizing sporadic and hereditary breast cancer (BC), including BRCA1/2-related hereditary breast and ovarian cancer syndrome (HBOC), Li-Fraumeni syndrome (TP53 mutations), and Lynch syndrome (MSI-driven BC). </p><h3 dir="ltr">Results</h3><p dir="ltr">Key genomic alterations such as TP53, BRCA1/2, and BCL2 mutations were found across various BC subtypes, including triple-negative, HER2-positive, and hormone receptor-positive tumors. Given the hereditary nature of some BC cases, genetic testing is crucial for risk assessment and early intervention, particularly as part of personalized screening protocols. Inhibiting these pathways with BCL2 inhibitors, PARP inhibitors for BRCA-mutated tumors, and immune checkpoint inhibitors for MSI-high tumors represents a promising therapeutic strategy. </p><h3 dir="ltr">Conclusions</h3><p dir="ltr">This review highlights the importance of integrating genomic findings into personalized care planning, genetic counseling, and patient education. </p><h3 dir="ltr">Implications for Nursing Practice</h3><p dir="ltr">Oncology nurses play a central role in applying genomic knowledge in patient care. They support informed decision-making regarding genetic testing, encourage adherence to surveillance protocols, monitor patients on targeted therapies, and advocate for equitable access to genetic services.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Seminars in Oncology Nursing<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.soncn.2025.152054" target="_blank">https://dx.doi.org/10.1016/j.soncn.2025.152054</a></p>2025-11-09T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.soncn.2025.152054https://figshare.com/articles/journal_contribution/Genomic_Instability_in_Hereditary_Breast_Cancer_Clinical_and_Nursing_Implications_for_Risk_Assessment_and_Targeted_Therapeutic_Strategies/30970714CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/309707142025-11-09T03:00:00Z |
| spellingShingle | Genomic Instability in Hereditary Breast Cancer: Clinical and Nursing Implications for Risk Assessment and Targeted Therapeutic Strategies Aladeen Alloubani (19334490) Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Health sciences Nursing Public health Hereditary breast cancer Genetic risk assessment Genomic instability Oncology nursing Hallmarks of cancer |
| status_str | publishedVersion |
| title | Genomic Instability in Hereditary Breast Cancer: Clinical and Nursing Implications for Risk Assessment and Targeted Therapeutic Strategies |
| title_full | Genomic Instability in Hereditary Breast Cancer: Clinical and Nursing Implications for Risk Assessment and Targeted Therapeutic Strategies |
| title_fullStr | Genomic Instability in Hereditary Breast Cancer: Clinical and Nursing Implications for Risk Assessment and Targeted Therapeutic Strategies |
| title_full_unstemmed | Genomic Instability in Hereditary Breast Cancer: Clinical and Nursing Implications for Risk Assessment and Targeted Therapeutic Strategies |
| title_short | Genomic Instability in Hereditary Breast Cancer: Clinical and Nursing Implications for Risk Assessment and Targeted Therapeutic Strategies |
| title_sort | Genomic Instability in Hereditary Breast Cancer: Clinical and Nursing Implications for Risk Assessment and Targeted Therapeutic Strategies |
| topic | Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Health sciences Nursing Public health Hereditary breast cancer Genetic risk assessment Genomic instability Oncology nursing Hallmarks of cancer |