Fatal Coronavirus Disease 2019-associated Pulmonary Aspergillosis; A Report of Two Cases and Review of the Literature
<p dir="ltr">Coronavirus Disease 2019 (COVID-19)-associated pulmonary aspergillosis is an emerging entity. We report two fatal cases of putative COVID-19-associated pulmonary aspergillosis. Both cases were diagnosed on the basis of respiratory tract cultures yielding Aspergillus spec...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , |
| منشور في: |
2020
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513558880976896 |
|---|---|
| author | Shiema Abdalla (9538596) |
| author2 | Muna A. Almaslamani (9538548) Samar M. Hashim (17100202) Abdulsalam S. Ibrahim (17100205) Ali S. Omrani (9590116) |
| author2_role | author author author author |
| author_facet | Shiema Abdalla (9538596) Muna A. Almaslamani (9538548) Samar M. Hashim (17100202) Abdulsalam S. Ibrahim (17100205) Ali S. Omrani (9590116) |
| author_role | author |
| dc.creator.none.fl_str_mv | Shiema Abdalla (9538596) Muna A. Almaslamani (9538548) Samar M. Hashim (17100202) Abdulsalam S. Ibrahim (17100205) Ali S. Omrani (9590116) |
| dc.date.none.fl_str_mv | 2020-08-22T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.idcr.2020.e00935 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Fatal_Coronavirus_Disease_2019-associated_Pulmonary_Aspergillosis_A_Report_of_Two_Cases_and_Review_of_the_Literature/24249856 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences COVID-19 aspergillosis ICU viral pneumonia |
| dc.title.none.fl_str_mv | Fatal Coronavirus Disease 2019-associated Pulmonary Aspergillosis; A Report of Two Cases and Review of the Literature |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Coronavirus Disease 2019 (COVID-19)-associated pulmonary aspergillosis is an emerging entity. We report two fatal cases of putative COVID-19-associated pulmonary aspergillosis. Both cases were diagnosed on the basis of respiratory tract cultures yielding Aspergillus species and otherwise unexplained clinical and radiological deterioration. Existing published literature on COVID-19-associated pulmonary aspergillosis indicate poor outcomes and high mortality. CAPA should be considered in patients with critical COVID-19 who have unexplained progressive respiratory failure despite optimized supportive care. Diagnostic work-up should be initiated as early as possible and should ideally include fungal cultures, galactomannan detection and Aspergillus PCR on tracheal aspirates or broncho-alveolar lavage fluid. Empiric systemic antifungal therapy may be justified in selected cases, pending diagnostic work up results. Large, multi-center studies are required to further understand the pathogenesis of invasive aspergillosis in COVID-19, and the optimal diagnostic and treatment strategies.</p><h2>Other Information</h2><p dir="ltr">Published in: IDCases<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.idcr.2020.e00935" target="_blank">https://dx.doi.org/10.1016/j.idcr.2020.e00935</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_c98dd134e3702a2fa2787954202b21a8 |
| identifier_str_mv | 10.1016/j.idcr.2020.e00935 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24249856 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Fatal Coronavirus Disease 2019-associated Pulmonary Aspergillosis; A Report of Two Cases and Review of the LiteratureShiema Abdalla (9538596)Muna A. Almaslamani (9538548)Samar M. Hashim (17100202)Abdulsalam S. Ibrahim (17100205)Ali S. Omrani (9590116)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesCOVID-19aspergillosisICUviral pneumonia<p dir="ltr">Coronavirus Disease 2019 (COVID-19)-associated pulmonary aspergillosis is an emerging entity. We report two fatal cases of putative COVID-19-associated pulmonary aspergillosis. Both cases were diagnosed on the basis of respiratory tract cultures yielding Aspergillus species and otherwise unexplained clinical and radiological deterioration. Existing published literature on COVID-19-associated pulmonary aspergillosis indicate poor outcomes and high mortality. CAPA should be considered in patients with critical COVID-19 who have unexplained progressive respiratory failure despite optimized supportive care. Diagnostic work-up should be initiated as early as possible and should ideally include fungal cultures, galactomannan detection and Aspergillus PCR on tracheal aspirates or broncho-alveolar lavage fluid. Empiric systemic antifungal therapy may be justified in selected cases, pending diagnostic work up results. Large, multi-center studies are required to further understand the pathogenesis of invasive aspergillosis in COVID-19, and the optimal diagnostic and treatment strategies.</p><h2>Other Information</h2><p dir="ltr">Published in: IDCases<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.idcr.2020.e00935" target="_blank">https://dx.doi.org/10.1016/j.idcr.2020.e00935</a></p>2020-08-22T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.idcr.2020.e00935https://figshare.com/articles/journal_contribution/Fatal_Coronavirus_Disease_2019-associated_Pulmonary_Aspergillosis_A_Report_of_Two_Cases_and_Review_of_the_Literature/24249856CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242498562020-08-22T00:00:00Z |
| spellingShingle | Fatal Coronavirus Disease 2019-associated Pulmonary Aspergillosis; A Report of Two Cases and Review of the Literature Shiema Abdalla (9538596) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences COVID-19 aspergillosis ICU viral pneumonia |
| status_str | publishedVersion |
| title | Fatal Coronavirus Disease 2019-associated Pulmonary Aspergillosis; A Report of Two Cases and Review of the Literature |
| title_full | Fatal Coronavirus Disease 2019-associated Pulmonary Aspergillosis; A Report of Two Cases and Review of the Literature |
| title_fullStr | Fatal Coronavirus Disease 2019-associated Pulmonary Aspergillosis; A Report of Two Cases and Review of the Literature |
| title_full_unstemmed | Fatal Coronavirus Disease 2019-associated Pulmonary Aspergillosis; A Report of Two Cases and Review of the Literature |
| title_short | Fatal Coronavirus Disease 2019-associated Pulmonary Aspergillosis; A Report of Two Cases and Review of the Literature |
| title_sort | Fatal Coronavirus Disease 2019-associated Pulmonary Aspergillosis; A Report of Two Cases and Review of the Literature |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences COVID-19 aspergillosis ICU viral pneumonia |