Hidradenitis suppurativa and its association with obesity, smoking, and diabetes mellitus: A systematic review and meta‐analysis
<p dir="ltr">Our meta‐analysis aimed to quantify the association between Hidradenitis suppurativa (HS) and several risk factors including obesity, smoking, and type 2 diabetes mellitus (T2DM). We searched PubMed, Scopus, Embase, Web of Science, and cumulative index to nursing and all...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2024
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513542018826240 |
|---|---|
| author | Khaled E. Elzawawi (22045253) |
| author2 | Ibrahim Elmakaty (14614270) Mohammad Habibullah (12829454) Mohamed Badie Ahmed (10223510) Salim Al Lahham (16515333) Sara Al Harami (16844383) Habib Albasti (16844132) Abeer Alsherawi (17945291) |
| author2_role | author author author author author author author |
| author_facet | Khaled E. Elzawawi (22045253) Ibrahim Elmakaty (14614270) Mohammad Habibullah (12829454) Mohamed Badie Ahmed (10223510) Salim Al Lahham (16515333) Sara Al Harami (16844383) Habib Albasti (16844132) Abeer Alsherawi (17945291) |
| author_role | author |
| dc.creator.none.fl_str_mv | Khaled E. Elzawawi (22045253) Ibrahim Elmakaty (14614270) Mohammad Habibullah (12829454) Mohamed Badie Ahmed (10223510) Salim Al Lahham (16515333) Sara Al Harami (16844383) Habib Albasti (16844132) Abeer Alsherawi (17945291) |
| dc.date.none.fl_str_mv | 2024-09-12T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1111/iwj.70035 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Hidradenitis_suppurativa_and_its_association_with_obesity_smoking_and_diabetes_mellitus_A_systematic_review_and_meta_analysis/29898563 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Health sciences Epidemiology acne inversus Hidradenitis suppurativa obesity smoking status type 2 diabetes mellitus |
| dc.title.none.fl_str_mv | Hidradenitis suppurativa and its association with obesity, smoking, and diabetes mellitus: A systematic review and meta‐analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Our meta‐analysis aimed to quantify the association between Hidradenitis suppurativa (HS) and several risk factors including obesity, smoking, and type 2 diabetes mellitus (T2DM). We searched PubMed, Scopus, Embase, Web of Science, and cumulative index to nursing and allied health literature for articles reporting either the odds ratio (OR) or the numbers of HS cases associated with obesity, smoking, or T2DM, and including HS negative controls. Risk of bias was assessed against the risk of bias in non‐randomized studies of interventions tool. Data synthesis was done using the random effects model with heterogeneity being evaluated with <i>I</i><sup><em>2</em></sup> statistic. Twenty‐three studies with a total of 29 562 087 patients (average age of 36.6 years) were included. Ten studies relied on country‐level data, while six studies collected their data from HS clinics. The analysis showed a significant association between HS and female sex (OR 2.34, 95% CI 1.89–2.90, <i>I</i><sup><em>2</em></sup> = 98.6%), DM (OR 2.78, 95% CI 2.23–3.47, <i>I</i><sup><em>2</em></sup> = 98.9%), obesity (OR 2.48, 95% CI 1.64–3.74, <i>I</i><sup><em>2</em></sup> = 99.9%), and smoking (OR 3.10 95% CI 2.60–3.69, <i>I</i><sup><em>2</em></sup> = 97.1%). Our meta‐analysis highlights HS links to sex, DM, obesity, and smoking, with emphasis on holistic management approach. Further research is needed on molecular mechanisms and additional risk factors for improved patient care.</p><h2>Other Information</h2><p dir="ltr">Published in: International Wound Journal<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/iwj.70035" target="_blank">https://dx.doi.org/10.1111/iwj.70035</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ca743e151c6d220ebe636fdd55c1a4ba |
| identifier_str_mv | 10.1111/iwj.70035 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29898563 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Hidradenitis suppurativa and its association with obesity, smoking, and diabetes mellitus: A systematic review and meta‐analysisKhaled E. Elzawawi (22045253)Ibrahim Elmakaty (14614270)Mohammad Habibullah (12829454)Mohamed Badie Ahmed (10223510)Salim Al Lahham (16515333)Sara Al Harami (16844383)Habib Albasti (16844132)Abeer Alsherawi (17945291)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsHealth sciencesEpidemiologyacne inversusHidradenitis suppurativaobesitysmoking statustype 2 diabetes mellitus<p dir="ltr">Our meta‐analysis aimed to quantify the association between Hidradenitis suppurativa (HS) and several risk factors including obesity, smoking, and type 2 diabetes mellitus (T2DM). We searched PubMed, Scopus, Embase, Web of Science, and cumulative index to nursing and allied health literature for articles reporting either the odds ratio (OR) or the numbers of HS cases associated with obesity, smoking, or T2DM, and including HS negative controls. Risk of bias was assessed against the risk of bias in non‐randomized studies of interventions tool. Data synthesis was done using the random effects model with heterogeneity being evaluated with <i>I</i><sup><em>2</em></sup> statistic. Twenty‐three studies with a total of 29 562 087 patients (average age of 36.6 years) were included. Ten studies relied on country‐level data, while six studies collected their data from HS clinics. The analysis showed a significant association between HS and female sex (OR 2.34, 95% CI 1.89–2.90, <i>I</i><sup><em>2</em></sup> = 98.6%), DM (OR 2.78, 95% CI 2.23–3.47, <i>I</i><sup><em>2</em></sup> = 98.9%), obesity (OR 2.48, 95% CI 1.64–3.74, <i>I</i><sup><em>2</em></sup> = 99.9%), and smoking (OR 3.10 95% CI 2.60–3.69, <i>I</i><sup><em>2</em></sup> = 97.1%). Our meta‐analysis highlights HS links to sex, DM, obesity, and smoking, with emphasis on holistic management approach. Further research is needed on molecular mechanisms and additional risk factors for improved patient care.</p><h2>Other Information</h2><p dir="ltr">Published in: International Wound Journal<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/iwj.70035" target="_blank">https://dx.doi.org/10.1111/iwj.70035</a></p>2024-09-12T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/iwj.70035https://figshare.com/articles/journal_contribution/Hidradenitis_suppurativa_and_its_association_with_obesity_smoking_and_diabetes_mellitus_A_systematic_review_and_meta_analysis/29898563CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/298985632024-09-12T09:00:00Z |
| spellingShingle | Hidradenitis suppurativa and its association with obesity, smoking, and diabetes mellitus: A systematic review and meta‐analysis Khaled E. Elzawawi (22045253) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Health sciences Epidemiology acne inversus Hidradenitis suppurativa obesity smoking status type 2 diabetes mellitus |
| status_str | publishedVersion |
| title | Hidradenitis suppurativa and its association with obesity, smoking, and diabetes mellitus: A systematic review and meta‐analysis |
| title_full | Hidradenitis suppurativa and its association with obesity, smoking, and diabetes mellitus: A systematic review and meta‐analysis |
| title_fullStr | Hidradenitis suppurativa and its association with obesity, smoking, and diabetes mellitus: A systematic review and meta‐analysis |
| title_full_unstemmed | Hidradenitis suppurativa and its association with obesity, smoking, and diabetes mellitus: A systematic review and meta‐analysis |
| title_short | Hidradenitis suppurativa and its association with obesity, smoking, and diabetes mellitus: A systematic review and meta‐analysis |
| title_sort | Hidradenitis suppurativa and its association with obesity, smoking, and diabetes mellitus: A systematic review and meta‐analysis |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Health sciences Epidemiology acne inversus Hidradenitis suppurativa obesity smoking status type 2 diabetes mellitus |