Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
<p dir="ltr">Tumor hypoxia is described as an oxygen deprivation in malignant tissue. The hypoxic condition is a consequence of an imbalance between rapidly proliferating cells and a vascularization that leads to lower oxygen levels in tumors. Hypoxia-inducible factor 1 (HIF-1) is an...
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| مؤلفون آخرون: | , , , , , , , , , , , , , , , |
| منشور في: |
2021
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إضافة وسم
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| _version_ | 1864513512385019904 |
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| author | Marek Samec (14727823) |
| author2 | Alena Liskova (11008851) Lenka Koklesova (18102994) Sandra Mersakova (16493790) Jan Strnadel (293905) Karol Kajo (5926877) Martin Pec (18877819) Kevin Zhai (18877843) Karel Smejkal (11912513) Sepideh Mirzaei (16935921) Kiavash Hushmandi (13025697) Milad Ashrafizadeh (12342797) Luciano Saso (404294) Aranka Brockmueller (11064675) Mehdi Shakibaei (325455) Dietrich Büsselberg (11008857) Peter Kubatka (11008854) |
| author2_role | author author author author author author author author author author author author author author author author |
| author_facet | Marek Samec (14727823) Alena Liskova (11008851) Lenka Koklesova (18102994) Sandra Mersakova (16493790) Jan Strnadel (293905) Karol Kajo (5926877) Martin Pec (18877819) Kevin Zhai (18877843) Karel Smejkal (11912513) Sepideh Mirzaei (16935921) Kiavash Hushmandi (13025697) Milad Ashrafizadeh (12342797) Luciano Saso (404294) Aranka Brockmueller (11064675) Mehdi Shakibaei (325455) Dietrich Büsselberg (11008857) Peter Kubatka (11008854) |
| author_role | author |
| dc.creator.none.fl_str_mv | Marek Samec (14727823) Alena Liskova (11008851) Lenka Koklesova (18102994) Sandra Mersakova (16493790) Jan Strnadel (293905) Karol Kajo (5926877) Martin Pec (18877819) Kevin Zhai (18877843) Karel Smejkal (11912513) Sepideh Mirzaei (16935921) Kiavash Hushmandi (13025697) Milad Ashrafizadeh (12342797) Luciano Saso (404294) Aranka Brockmueller (11064675) Mehdi Shakibaei (325455) Dietrich Büsselberg (11008857) Peter Kubatka (11008854) |
| dc.date.none.fl_str_mv | 2021-01-03T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cancers13010130 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Flavonoids_Targeting_HIF-1_Implications_on_Cancer_Metabolism/26095738 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis cancer Warburg effect HIF-1 flavonoids |
| dc.title.none.fl_str_mv | Flavonoids Targeting HIF-1: Implications on Cancer Metabolism |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Tumor hypoxia is described as an oxygen deprivation in malignant tissue. The hypoxic condition is a consequence of an imbalance between rapidly proliferating cells and a vascularization that leads to lower oxygen levels in tumors. Hypoxia-inducible factor 1 (HIF-1) is an essential transcription factor contributing to the regulation of hypoxia-associated genes. Some of these genes modulate molecular cascades associated with the Warburg effect and its accompanying pathways and, therefore, represent promising targets for cancer treatment. Current progress in the development of therapeutic approaches brings several promising inhibitors of HIF-1. Flavonoids, widely occurring in various plants, exert a broad spectrum of beneficial effects on human health, and are potentially powerful therapeutic tools against cancer. Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK). Here, we discuss the results of most recent studies evaluating the impact of flavonoids on HIF-1 accompanied by the regulation of critical enzymes contributing to the Warburg phenotype. Besides, flavonoid effects on glucose metabolism via regulation of HIF-1 activity represent a promising avenue in cancer-related research. At the same time, only more-in depth investigations can further elucidate the mechanistic and clinical connections between HIF-1 and cancer metabolism.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancers<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers13010130" target="_blank">https://dx.doi.org/10.3390/cancers13010130</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_caea7c3366f822382de80279810ecd4e |
| identifier_str_mv | 10.3390/cancers13010130 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26095738 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Flavonoids Targeting HIF-1: Implications on Cancer MetabolismMarek Samec (14727823)Alena Liskova (11008851)Lenka Koklesova (18102994)Sandra Mersakova (16493790)Jan Strnadel (293905)Karol Kajo (5926877)Martin Pec (18877819)Kevin Zhai (18877843)Karel Smejkal (11912513)Sepideh Mirzaei (16935921)Kiavash Hushmandi (13025697)Milad Ashrafizadeh (12342797)Luciano Saso (404294)Aranka Brockmueller (11064675)Mehdi Shakibaei (325455)Dietrich Büsselberg (11008857)Peter Kubatka (11008854)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesOncology and carcinogenesiscancerWarburg effectHIF-1flavonoids<p dir="ltr">Tumor hypoxia is described as an oxygen deprivation in malignant tissue. The hypoxic condition is a consequence of an imbalance between rapidly proliferating cells and a vascularization that leads to lower oxygen levels in tumors. Hypoxia-inducible factor 1 (HIF-1) is an essential transcription factor contributing to the regulation of hypoxia-associated genes. Some of these genes modulate molecular cascades associated with the Warburg effect and its accompanying pathways and, therefore, represent promising targets for cancer treatment. Current progress in the development of therapeutic approaches brings several promising inhibitors of HIF-1. Flavonoids, widely occurring in various plants, exert a broad spectrum of beneficial effects on human health, and are potentially powerful therapeutic tools against cancer. Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK). Here, we discuss the results of most recent studies evaluating the impact of flavonoids on HIF-1 accompanied by the regulation of critical enzymes contributing to the Warburg phenotype. Besides, flavonoid effects on glucose metabolism via regulation of HIF-1 activity represent a promising avenue in cancer-related research. At the same time, only more-in depth investigations can further elucidate the mechanistic and clinical connections between HIF-1 and cancer metabolism.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancers<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers13010130" target="_blank">https://dx.doi.org/10.3390/cancers13010130</a></p>2021-01-03T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cancers13010130https://figshare.com/articles/journal_contribution/Flavonoids_Targeting_HIF-1_Implications_on_Cancer_Metabolism/26095738CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/260957382021-01-03T03:00:00Z |
| spellingShingle | Flavonoids Targeting HIF-1: Implications on Cancer Metabolism Marek Samec (14727823) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis cancer Warburg effect HIF-1 flavonoids |
| status_str | publishedVersion |
| title | Flavonoids Targeting HIF-1: Implications on Cancer Metabolism |
| title_full | Flavonoids Targeting HIF-1: Implications on Cancer Metabolism |
| title_fullStr | Flavonoids Targeting HIF-1: Implications on Cancer Metabolism |
| title_full_unstemmed | Flavonoids Targeting HIF-1: Implications on Cancer Metabolism |
| title_short | Flavonoids Targeting HIF-1: Implications on Cancer Metabolism |
| title_sort | Flavonoids Targeting HIF-1: Implications on Cancer Metabolism |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis cancer Warburg effect HIF-1 flavonoids |