Uncovering a neurological protein signature for severe COVID-19
<p dir="ltr">Coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has sparked a global pandemic with severe complications and high morbidity rate. Neurological symptoms in COVID-19 patients, and neurological sequelae post COV...
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2023
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| _version_ | 1864513510796427264 |
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| author | Omar El-Agnaf (2134222) |
| author2 | Ilham Bensmail (12204845) Maryam A.Y. Al-Nesf (15468644) James Flynn (240802) Mark Taylor (65647) Nour K. Majbour (8809316) Ilham Y. Abdi (14778898) Nishant N. Vaikath (2901785) Abdulaziz Farooq (5345384) Praveen B. Vemulapalli (15468652) Frank Schmidt (207186) Khalid Ouararhni (3145734) Heba H Al-Siddiqi (12204889) Abdelilah Arredouani (14070786) Patrick Wijten (2029159) Mohammed Al-Maadheed (12204886) Vidya Mohamed-Ali (12204895) Julie Decock (44558) Houari B. Abdesselem (14152827) |
| author2_role | author author author author author author author author author author author author author author author author author author |
| author_facet | Omar El-Agnaf (2134222) Ilham Bensmail (12204845) Maryam A.Y. Al-Nesf (15468644) James Flynn (240802) Mark Taylor (65647) Nour K. Majbour (8809316) Ilham Y. Abdi (14778898) Nishant N. Vaikath (2901785) Abdulaziz Farooq (5345384) Praveen B. Vemulapalli (15468652) Frank Schmidt (207186) Khalid Ouararhni (3145734) Heba H Al-Siddiqi (12204889) Abdelilah Arredouani (14070786) Patrick Wijten (2029159) Mohammed Al-Maadheed (12204886) Vidya Mohamed-Ali (12204895) Julie Decock (44558) Houari B. Abdesselem (14152827) |
| author_role | author |
| dc.creator.none.fl_str_mv | Omar El-Agnaf (2134222) Ilham Bensmail (12204845) Maryam A.Y. Al-Nesf (15468644) James Flynn (240802) Mark Taylor (65647) Nour K. Majbour (8809316) Ilham Y. Abdi (14778898) Nishant N. Vaikath (2901785) Abdulaziz Farooq (5345384) Praveen B. Vemulapalli (15468652) Frank Schmidt (207186) Khalid Ouararhni (3145734) Heba H Al-Siddiqi (12204889) Abdelilah Arredouani (14070786) Patrick Wijten (2029159) Mohammed Al-Maadheed (12204886) Vidya Mohamed-Ali (12204895) Julie Decock (44558) Houari B. Abdesselem (14152827) |
| dc.date.none.fl_str_mv | 2023-06-15T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.nbd.2023.106147 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Uncovering_a_neurological_protein_signature_for_severe_COVID-19/22820939 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Severe COVID-19 Neurological complications Olink proteomics Protein signature Neurological Disorders Research Center (QBRI) Translational Cancer and Immunity Center (QBRI) Diabetes Research Center (QBRI) FIFA Medical Centre of Excellence Doha, Qatar (Aspetar) |
| dc.title.none.fl_str_mv | Uncovering a neurological protein signature for severe COVID-19 |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has sparked a global pandemic with severe complications and high morbidity rate. Neurological symptoms in COVID-19 patients, and neurological sequelae post COVID-19 recovery have been extensively reported. Yet, neurological molecular signature and signaling pathways that are affected in the central nervous system (CNS) of COVID-19 severe patients remain still unknown and need to be identified. Plasma samples from 49 severe COVID-19 patients, 50 mild COVID-19 patients, and 40 healthy controls were subjected to Olink proteomics analysis of 184 CNS-enriched proteins. By using a multi-approach bioinformatics analysis, we identified a 34-neurological protein signature for COVID-19 severity and unveiled dysregulated neurological pathways in severe cases. Here, we identified a new neurological protein signature for severe COVID-19 that was validated in different independent cohorts using blood and postmortem brain samples and shown to correlate with neurological diseases and pharmacological drugs. This protein signature could potentially aid the development of prognostic and diagnostic tools for neurological complications in post-COVID-19 convalescent patients with long term neurological sequelae.</p><h2>Other information</h2><p dir="ltr">Published in: Neurobiology of Disease<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher'swebsite: <a href="https://doi.org/10.1016/j.nbd.2023.106147" target="_blank">https://doi.org/10.1016/j.nbd.2023.106147</a><br><a href="http://dx.doi.org/10.2147/pgpm.s391394" target="_blank"></a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_cb18825cae8ff40bcf96ad113a321c27 |
| identifier_str_mv | 10.1016/j.nbd.2023.106147 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22820939 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Uncovering a neurological protein signature for severe COVID-19Omar El-Agnaf (2134222)Ilham Bensmail (12204845)Maryam A.Y. Al-Nesf (15468644)James Flynn (240802)Mark Taylor (65647)Nour K. Majbour (8809316)Ilham Y. Abdi (14778898)Nishant N. Vaikath (2901785)Abdulaziz Farooq (5345384)Praveen B. Vemulapalli (15468652)Frank Schmidt (207186)Khalid Ouararhni (3145734)Heba H Al-Siddiqi (12204889)Abdelilah Arredouani (14070786)Patrick Wijten (2029159)Mohammed Al-Maadheed (12204886)Vidya Mohamed-Ali (12204895)Julie Decock (44558)Houari B. Abdesselem (14152827)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesCardiovascular medicine and haematologyNeurosciencesSevere COVID-19Neurological complicationsOlink proteomicsProtein signatureNeurological Disorders Research Center (QBRI)Translational Cancer and Immunity Center (QBRI)Diabetes Research Center (QBRI)FIFA Medical Centre of Excellence Doha, Qatar (Aspetar)<p dir="ltr">Coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has sparked a global pandemic with severe complications and high morbidity rate. Neurological symptoms in COVID-19 patients, and neurological sequelae post COVID-19 recovery have been extensively reported. Yet, neurological molecular signature and signaling pathways that are affected in the central nervous system (CNS) of COVID-19 severe patients remain still unknown and need to be identified. Plasma samples from 49 severe COVID-19 patients, 50 mild COVID-19 patients, and 40 healthy controls were subjected to Olink proteomics analysis of 184 CNS-enriched proteins. By using a multi-approach bioinformatics analysis, we identified a 34-neurological protein signature for COVID-19 severity and unveiled dysregulated neurological pathways in severe cases. Here, we identified a new neurological protein signature for severe COVID-19 that was validated in different independent cohorts using blood and postmortem brain samples and shown to correlate with neurological diseases and pharmacological drugs. This protein signature could potentially aid the development of prognostic and diagnostic tools for neurological complications in post-COVID-19 convalescent patients with long term neurological sequelae.</p><h2>Other information</h2><p dir="ltr">Published in: Neurobiology of Disease<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher'swebsite: <a href="https://doi.org/10.1016/j.nbd.2023.106147" target="_blank">https://doi.org/10.1016/j.nbd.2023.106147</a><br><a href="http://dx.doi.org/10.2147/pgpm.s391394" target="_blank"></a></p>2023-06-15T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.nbd.2023.106147https://figshare.com/articles/journal_contribution/Uncovering_a_neurological_protein_signature_for_severe_COVID-19/22820939CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/228209392023-06-15T00:00:00Z |
| spellingShingle | Uncovering a neurological protein signature for severe COVID-19 Omar El-Agnaf (2134222) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Severe COVID-19 Neurological complications Olink proteomics Protein signature Neurological Disorders Research Center (QBRI) Translational Cancer and Immunity Center (QBRI) Diabetes Research Center (QBRI) FIFA Medical Centre of Excellence Doha, Qatar (Aspetar) |
| status_str | publishedVersion |
| title | Uncovering a neurological protein signature for severe COVID-19 |
| title_full | Uncovering a neurological protein signature for severe COVID-19 |
| title_fullStr | Uncovering a neurological protein signature for severe COVID-19 |
| title_full_unstemmed | Uncovering a neurological protein signature for severe COVID-19 |
| title_short | Uncovering a neurological protein signature for severe COVID-19 |
| title_sort | Uncovering a neurological protein signature for severe COVID-19 |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Severe COVID-19 Neurological complications Olink proteomics Protein signature Neurological Disorders Research Center (QBRI) Translational Cancer and Immunity Center (QBRI) Diabetes Research Center (QBRI) FIFA Medical Centre of Excellence Doha, Qatar (Aspetar) |