Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight
<h3>Background</h3><p dir="ltr">Polycystic ovary syndrome (PCOS) is a complex syndrome with clinical features of an endocrine/metabolic disorder. Various metabolites show significant association with PCOS; however, studies comparing the metabolic profile of pregnant women...
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| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2021
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| _version_ | 1864513516670550016 |
|---|---|
| author | Ilhame Diboun (3522413) |
| author2 | Manjunath Ramanjaneya (519259) Lina Ahmed (3342308) Mohammed Bashir (5593550) Alexandra E. Butler (6189536) Omar Albagha (8977856) Abdul Badi Abou-Samra (9417977) Stephen L. Atkin (6684368) Nayef A. Mazloum (7355087) Mohamed A. Elrayess (7956179) |
| author2_role | author author author author author author author author author |
| author_facet | Ilhame Diboun (3522413) Manjunath Ramanjaneya (519259) Lina Ahmed (3342308) Mohammed Bashir (5593550) Alexandra E. Butler (6189536) Omar Albagha (8977856) Abdul Badi Abou-Samra (9417977) Stephen L. Atkin (6684368) Nayef A. Mazloum (7355087) Mohamed A. Elrayess (7956179) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ilhame Diboun (3522413) Manjunath Ramanjaneya (519259) Lina Ahmed (3342308) Mohammed Bashir (5593550) Alexandra E. Butler (6189536) Omar Albagha (8977856) Abdul Badi Abou-Samra (9417977) Stephen L. Atkin (6684368) Nayef A. Mazloum (7355087) Mohamed A. Elrayess (7956179) |
| dc.date.none.fl_str_mv | 2021-06-15T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fendo.2021.638727 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Metabolomic_Profiling_of_Pregnancies_With_Polycystic_Ovary_Syndrome_Identifies_a_Unique_Metabolic_Signature_and_Potential_Predictive_Biomarkers_of_Low_Birth_Weight/25771536 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Reproductive medicine metabolomics pregnancy polycystic ovary syndrome (PCOS) birth weight arachidonic acid linoleic acid palmitic acid |
| dc.title.none.fl_str_mv | Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Polycystic ovary syndrome (PCOS) is a complex syndrome with clinical features of an endocrine/metabolic disorder. Various metabolites show significant association with PCOS; however, studies comparing the metabolic profile of pregnant women with and without PCOS are lacking. In this study, metabolomics analysis of blood samples collected from PCOS women and age and BMI matched controls in the second trimester of pregnancy was performed to identify metabolic differences between the two groups and determine their association with pregnancy outcome.</p><h3>Methods</h3><p dir="ltr">Sixteen PCOS and fifty-two healthy women in their second trimester underwent targeted metabolomics of plasma samples using tandem mass spectrometry with the Biocrates MxP® Quant 500 Kit. Linear regression models were used to identify the metabolic alterations associated with PCOS, followed by enrichment and Receiver Operating Characteristic (ROC) analyses to determine the best indicators of pregnancy outcomes.</p><h3>Results</h3><p dir="ltr">PCOS women had lower birth weight babies compared to healthy controls. As a group, systolic blood pressure (SBP) at both second trimester and at delivery negatively correlated with birth weight. Regression models indicated significant increases in the triglycerides C20:4_C34:3 and C18:2_C38:6 in the PCOS group [false discovery rate (FDR) <0.05]. Enrichment analysis revealed significant elevations in triglycerides containing arachidonic acid, linoleic acid and palmitic acid in the PCOS group. A number of indicators of baby birth weight were identified including SBP at delivery, hexosylceramide (d18:2/24:0), ceramide (d18.0/24.1) and serine, with an AUC for all predictors combined for low birth weight (≤2500grams) of 0.88 (95%CI: 0.75-1.005, p<0.001).</p><h3>Conclusions</h3><p dir="ltr">PCOS pregnancies resulted in babies with a lower birth weight, marked by a unique metabolic signature that was enriched with specific triglycerides and unsaturated fatty acids. The functional significance of these associations needs further investigation.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2021.638727" target="_blank">https://dx.doi.org/10.3389/fendo.2021.638727</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_cb86a7649fee4551f4b5820d10697c8b |
| identifier_str_mv | 10.3389/fendo.2021.638727 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25771536 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth WeightIlhame Diboun (3522413)Manjunath Ramanjaneya (519259)Lina Ahmed (3342308)Mohammed Bashir (5593550)Alexandra E. Butler (6189536)Omar Albagha (8977856)Abdul Badi Abou-Samra (9417977)Stephen L. Atkin (6684368)Nayef A. Mazloum (7355087)Mohamed A. Elrayess (7956179)Biomedical and clinical sciencesClinical sciencesReproductive medicinemetabolomicspregnancypolycystic ovary syndrome (PCOS)birth weightarachidonic acidlinoleic acidpalmitic acid<h3>Background</h3><p dir="ltr">Polycystic ovary syndrome (PCOS) is a complex syndrome with clinical features of an endocrine/metabolic disorder. Various metabolites show significant association with PCOS; however, studies comparing the metabolic profile of pregnant women with and without PCOS are lacking. In this study, metabolomics analysis of blood samples collected from PCOS women and age and BMI matched controls in the second trimester of pregnancy was performed to identify metabolic differences between the two groups and determine their association with pregnancy outcome.</p><h3>Methods</h3><p dir="ltr">Sixteen PCOS and fifty-two healthy women in their second trimester underwent targeted metabolomics of plasma samples using tandem mass spectrometry with the Biocrates MxP® Quant 500 Kit. Linear regression models were used to identify the metabolic alterations associated with PCOS, followed by enrichment and Receiver Operating Characteristic (ROC) analyses to determine the best indicators of pregnancy outcomes.</p><h3>Results</h3><p dir="ltr">PCOS women had lower birth weight babies compared to healthy controls. As a group, systolic blood pressure (SBP) at both second trimester and at delivery negatively correlated with birth weight. Regression models indicated significant increases in the triglycerides C20:4_C34:3 and C18:2_C38:6 in the PCOS group [false discovery rate (FDR) <0.05]. Enrichment analysis revealed significant elevations in triglycerides containing arachidonic acid, linoleic acid and palmitic acid in the PCOS group. A number of indicators of baby birth weight were identified including SBP at delivery, hexosylceramide (d18:2/24:0), ceramide (d18.0/24.1) and serine, with an AUC for all predictors combined for low birth weight (≤2500grams) of 0.88 (95%CI: 0.75-1.005, p<0.001).</p><h3>Conclusions</h3><p dir="ltr">PCOS pregnancies resulted in babies with a lower birth weight, marked by a unique metabolic signature that was enriched with specific triglycerides and unsaturated fatty acids. The functional significance of these associations needs further investigation.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2021.638727" target="_blank">https://dx.doi.org/10.3389/fendo.2021.638727</a></p>2021-06-15T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fendo.2021.638727https://figshare.com/articles/journal_contribution/Metabolomic_Profiling_of_Pregnancies_With_Polycystic_Ovary_Syndrome_Identifies_a_Unique_Metabolic_Signature_and_Potential_Predictive_Biomarkers_of_Low_Birth_Weight/25771536CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/257715362021-06-15T03:00:00Z |
| spellingShingle | Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight Ilhame Diboun (3522413) Biomedical and clinical sciences Clinical sciences Reproductive medicine metabolomics pregnancy polycystic ovary syndrome (PCOS) birth weight arachidonic acid linoleic acid palmitic acid |
| status_str | publishedVersion |
| title | Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight |
| title_full | Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight |
| title_fullStr | Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight |
| title_full_unstemmed | Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight |
| title_short | Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight |
| title_sort | Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight |
| topic | Biomedical and clinical sciences Clinical sciences Reproductive medicine metabolomics pregnancy polycystic ovary syndrome (PCOS) birth weight arachidonic acid linoleic acid palmitic acid |