The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses
<div><p>The objective was to delineate hepatitis C virus (HCV) epidemiology in countries of Central Asia (CA), specifically Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. A systematic review was conducted guided by the Cochrane Collaboration Handbook, and reported usin...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , |
| Published: |
2019
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513513952641024 |
|---|---|
| author | Welathanthrige S. P. Botheju (18618643) |
| author2 | Fawzi Zghyer (14779651) Sarwat Mahmud (4557208) Assel Terlikbayeva (310190) Nabila El-Bassel (654680) Laith J. Abu-Raddad (9262524) |
| author2_role | author author author author author |
| author_facet | Welathanthrige S. P. Botheju (18618643) Fawzi Zghyer (14779651) Sarwat Mahmud (4557208) Assel Terlikbayeva (310190) Nabila El-Bassel (654680) Laith J. Abu-Raddad (9262524) |
| author_role | author |
| dc.creator.none.fl_str_mv | Welathanthrige S. P. Botheju (18618643) Fawzi Zghyer (14779651) Sarwat Mahmud (4557208) Assel Terlikbayeva (310190) Nabila El-Bassel (654680) Laith J. Abu-Raddad (9262524) |
| dc.date.none.fl_str_mv | 2019-02-14T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41598-019-38853-8 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_epidemiology_of_hepatitis_C_virus_in_Central_Asia_Systematic_review_meta-analyses_and_meta-regression_analyses/25907569 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Health sciences Epidemiology Mathematical sciences Statistics Hepatitis C Virus (HCV) Epidemiology Central Asia (CA) Prevalence Incidence Genotypes Clinical Populations |
| dc.title.none.fl_str_mv | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>The objective was to delineate hepatitis C virus (HCV) epidemiology in countries of Central Asia (CA), specifically Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. A systematic review was conducted guided by the Cochrane Collaboration Handbook, and reported using PRISMA guidelines. Meta-analyses were performed using DerSimonian-Laird random-effects models with inverse variance weighting. Random-effects meta-regression analyses were performed on general population studies. The systematic review identified a total of 208 HCV prevalence measures. No incidence or Turkmenistan studies were identified. Meta-analyses estimated HCV prevalence among the general population at 0.7% (95%CI: 0.7–0.8%) in Kazakhstan, 2.0% (95%CI: 1.7–2.4%) in Kyrgyzstan, 2.6% (95%CI: 1.7–3.6%) in Tajikistan, and 9.6 (95%CI: 5.8–14.2%) in Uzbekistan. Across CA, the pooled mean prevalence was 13.5% (95%CI: 10.9–16.4%) among non-specific clinical populations, 31.6% (95%CI: 25.8–37.7%) among populations with liver-related conditions, and 51.3% (95%CI: 46.9–55.6%) among people who inject drugs. Genotypes 1 (52.6%) and 3 (38.0%) were most frequent. Evidence was found for statistically-significant differences in prevalence by country, but not for a temporal decline in prevalence. CA is one of the most affected regions by HCV infection with Uzbekistan enduring one of the highest prevalence levels worldwide. Ongoing HCV transmission seems to be driven by injecting drug use and healthcare exposures.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Scientific Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-019-38853-8" target="_blank">https://dx.doi.org/10.1038/s41598-019-38853-8</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_cbd90e13d31c7c8665848832f33764e8 |
| identifier_str_mv | 10.1038/s41598-019-38853-8 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25907569 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analysesWelathanthrige S. P. Botheju (18618643)Fawzi Zghyer (14779651)Sarwat Mahmud (4557208)Assel Terlikbayeva (310190)Nabila El-Bassel (654680)Laith J. Abu-Raddad (9262524)Health sciencesEpidemiologyMathematical sciencesStatisticsHepatitis C Virus (HCV)EpidemiologyCentral Asia (CA)PrevalenceIncidenceGenotypesClinical Populations<div><p>The objective was to delineate hepatitis C virus (HCV) epidemiology in countries of Central Asia (CA), specifically Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. A systematic review was conducted guided by the Cochrane Collaboration Handbook, and reported using PRISMA guidelines. Meta-analyses were performed using DerSimonian-Laird random-effects models with inverse variance weighting. Random-effects meta-regression analyses were performed on general population studies. The systematic review identified a total of 208 HCV prevalence measures. No incidence or Turkmenistan studies were identified. Meta-analyses estimated HCV prevalence among the general population at 0.7% (95%CI: 0.7–0.8%) in Kazakhstan, 2.0% (95%CI: 1.7–2.4%) in Kyrgyzstan, 2.6% (95%CI: 1.7–3.6%) in Tajikistan, and 9.6 (95%CI: 5.8–14.2%) in Uzbekistan. Across CA, the pooled mean prevalence was 13.5% (95%CI: 10.9–16.4%) among non-specific clinical populations, 31.6% (95%CI: 25.8–37.7%) among populations with liver-related conditions, and 51.3% (95%CI: 46.9–55.6%) among people who inject drugs. Genotypes 1 (52.6%) and 3 (38.0%) were most frequent. Evidence was found for statistically-significant differences in prevalence by country, but not for a temporal decline in prevalence. CA is one of the most affected regions by HCV infection with Uzbekistan enduring one of the highest prevalence levels worldwide. Ongoing HCV transmission seems to be driven by injecting drug use and healthcare exposures.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Scientific Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-019-38853-8" target="_blank">https://dx.doi.org/10.1038/s41598-019-38853-8</a></p>2019-02-14T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41598-019-38853-8https://figshare.com/articles/journal_contribution/The_epidemiology_of_hepatitis_C_virus_in_Central_Asia_Systematic_review_meta-analyses_and_meta-regression_analyses/25907569CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/259075692019-02-14T03:00:00Z |
| spellingShingle | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses Welathanthrige S. P. Botheju (18618643) Health sciences Epidemiology Mathematical sciences Statistics Hepatitis C Virus (HCV) Epidemiology Central Asia (CA) Prevalence Incidence Genotypes Clinical Populations |
| status_str | publishedVersion |
| title | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
| title_full | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
| title_fullStr | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
| title_full_unstemmed | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
| title_short | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
| title_sort | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
| topic | Health sciences Epidemiology Mathematical sciences Statistics Hepatitis C Virus (HCV) Epidemiology Central Asia (CA) Prevalence Incidence Genotypes Clinical Populations |