Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences
<p dir="ltr">Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May 2022, it had caused more than 500 million infections and more than 6 million deaths worldwide...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| منشور في: |
2022
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513548275679232 |
|---|---|
| author | Reem Hoteit (9929845) |
| author2 | Hadi M. Yassine (4675846) |
| author2_role | author |
| author_facet | Reem Hoteit (9929845) Hadi M. Yassine (4675846) |
| author_role | author |
| dc.creator.none.fl_str_mv | Reem Hoteit (9929845) Hadi M. Yassine (4675846) |
| dc.date.none.fl_str_mv | 2022-06-09T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/vaccines10060919 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Biological_Properties_of_SARS-CoV-2_Variants_Epidemiological_Impact_and_Clinical_Consequences/29069549 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Microbiology Biomedical and clinical sciences Immunology Health sciences Epidemiology Public health severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease 2019 (COVID-19) variants of concern (VOCs) mutations epidemiological factors clinical consequences |
| dc.title.none.fl_str_mv | Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May 2022, it had caused more than 500 million infections and more than 6 million deaths worldwide. Several vaccines have been produced and tested over the last two years. The SARS-CoV-2 virus, on the other hand, has mutated over time, resulting in genetic variation in the population of circulating variants during the COVID-19 pandemic. It has also shown immune-evading characteristics, suggesting that vaccinations against these variants could be potentially ineffective. The purpose of this review article is to investigate the key variants of concern (VOCs) and mutations of the virus driving the current pandemic, as well as to explore the transmission rates of SARS-CoV-2 VOCs in relation to epidemiological factors and to compare the virus’s transmission rate to that of prior coronaviruses. We examined and provided key information on SARS-CoV-2 VOCs in this study, including their transmissibility, infectivity rate, disease severity, affinity for angiotensin-converting enzyme 2 (ACE2) receptors, viral load, reproduction number, vaccination effectiveness, and vaccine breakthrough.</p><h2>Other Information</h2><p dir="ltr">Published in: Vaccines<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/vaccines10060919" target="_blank">https://dx.doi.org/10.3390/vaccines10060919</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_cd4654c0fc492cd82565440af7037090 |
| identifier_str_mv | 10.3390/vaccines10060919 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29069549 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical ConsequencesReem Hoteit (9929845)Hadi M. Yassine (4675846)Biological sciencesMicrobiologyBiomedical and clinical sciencesImmunologyHealth sciencesEpidemiologyPublic healthsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)coronavirus disease 2019 (COVID-19)variants of concern (VOCs)mutationsepidemiological factorsclinical consequences<p dir="ltr">Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May 2022, it had caused more than 500 million infections and more than 6 million deaths worldwide. Several vaccines have been produced and tested over the last two years. The SARS-CoV-2 virus, on the other hand, has mutated over time, resulting in genetic variation in the population of circulating variants during the COVID-19 pandemic. It has also shown immune-evading characteristics, suggesting that vaccinations against these variants could be potentially ineffective. The purpose of this review article is to investigate the key variants of concern (VOCs) and mutations of the virus driving the current pandemic, as well as to explore the transmission rates of SARS-CoV-2 VOCs in relation to epidemiological factors and to compare the virus’s transmission rate to that of prior coronaviruses. We examined and provided key information on SARS-CoV-2 VOCs in this study, including their transmissibility, infectivity rate, disease severity, affinity for angiotensin-converting enzyme 2 (ACE2) receptors, viral load, reproduction number, vaccination effectiveness, and vaccine breakthrough.</p><h2>Other Information</h2><p dir="ltr">Published in: Vaccines<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/vaccines10060919" target="_blank">https://dx.doi.org/10.3390/vaccines10060919</a></p>2022-06-09T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/vaccines10060919https://figshare.com/articles/journal_contribution/Biological_Properties_of_SARS-CoV-2_Variants_Epidemiological_Impact_and_Clinical_Consequences/29069549CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/290695492022-06-09T03:00:00Z |
| spellingShingle | Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences Reem Hoteit (9929845) Biological sciences Microbiology Biomedical and clinical sciences Immunology Health sciences Epidemiology Public health severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease 2019 (COVID-19) variants of concern (VOCs) mutations epidemiological factors clinical consequences |
| status_str | publishedVersion |
| title | Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences |
| title_full | Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences |
| title_fullStr | Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences |
| title_full_unstemmed | Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences |
| title_short | Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences |
| title_sort | Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences |
| topic | Biological sciences Microbiology Biomedical and clinical sciences Immunology Health sciences Epidemiology Public health severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease 2019 (COVID-19) variants of concern (VOCs) mutations epidemiological factors clinical consequences |