Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development
<p>Metal-Organic Framework MIL-89 nanoparticles garnered remarkable attention for their widespread use in technological applications. However, the impact of these nanomaterials on human and environmental health is still limited, and concerns regarding the potential risk of exposure during mani...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , |
| منشور في: |
2022
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513536142606336 |
|---|---|
| author | Dana E. Al-Ansari (16327350) |
| author2 | Mashael Al-Badr (17563128) Zain Z. Zakaria (6695093) Nura Adam Mohamed (17563131) Gheyath K. Nasrallah (9200525) Huseyin C. Yalcin (6695099) Haissam Abou-Saleh (497840) |
| author2_role | author author author author author author |
| author_facet | Dana E. Al-Ansari (16327350) Mashael Al-Badr (17563128) Zain Z. Zakaria (6695093) Nura Adam Mohamed (17563131) Gheyath K. Nasrallah (9200525) Huseyin C. Yalcin (6695099) Haissam Abou-Saleh (497840) |
| author_role | author |
| dc.creator.none.fl_str_mv | Dana E. Al-Ansari (16327350) Mashael Al-Badr (17563128) Zain Z. Zakaria (6695093) Nura Adam Mohamed (17563131) Gheyath K. Nasrallah (9200525) Huseyin C. Yalcin (6695099) Haissam Abou-Saleh (497840) |
| dc.date.none.fl_str_mv | 2022-04-20T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.toxrep.2022.04.016 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Evaluation_of_Metal_Organic_Framework_MIL-89_nanoparticles_toxicity_on_embryonic_zebrafish_development/24745671 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biotechnology Engineering Biomedical engineering Nanotechnology Danio rerio Larvae Development Organ toxicity Nanotechnology |
| dc.title.none.fl_str_mv | Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Metal-Organic Framework MIL-89 nanoparticles garnered remarkable attention for their widespread use in technological applications. However, the impact of these nanomaterials on human and environmental health is still limited, and concerns regarding the potential risk of exposure during manipulation is constantly rising. Therefore, the extensive use of nanomaterials in the medical field necessitates a comprehensive assessment of their safety and interaction with different tissues of the body system. In this study, we evaluated the systemic toxicity of nanoMIL-89 using Zebrafish embryos as a model system to determine the acute developmental effect. Zebrafish embryos were exposed to a range of nanoMIL-89 concentrations (1 – 300 µM) at 4 h post-fertilization (hpf) for up to 120 hpf. The viability and hatching rate were evaluated at 24–72 hpf, whereas the cardiac function was assessed at 72 and 96 hpf, and the neurodevelopment and hepatic steatosis at 120 hpf. Our study shows that nanoMIL-89 exerted no developmental toxicity on zebrafish embryos at low concentrations (1–10 µM). However, the hatching time and heart development were affected at high concentrations of nanoMIL-89 (> 30 µM). Our findings add novel information into the available data about the in vivo toxicity of nanoMIL-89 and demonstrate its innocuity and safe use in biological, environmental, and medical applications.</p><h2>Other Information</h2> <p> Published in: Toxicology Reports<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.toxrep.2022.04.016" target="_blank">https://dx.doi.org/10.1016/j.toxrep.2022.04.016</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ce8826b6cb1de7409e1bd7feb35523fc |
| identifier_str_mv | 10.1016/j.toxrep.2022.04.016 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24745671 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish developmentDana E. Al-Ansari (16327350)Mashael Al-Badr (17563128)Zain Z. Zakaria (6695093)Nura Adam Mohamed (17563131)Gheyath K. Nasrallah (9200525)Huseyin C. Yalcin (6695099)Haissam Abou-Saleh (497840)Biomedical and clinical sciencesMedical biotechnologyEngineeringBiomedical engineeringNanotechnologyDanio rerioLarvaeDevelopmentOrgan toxicityNanotechnology<p>Metal-Organic Framework MIL-89 nanoparticles garnered remarkable attention for their widespread use in technological applications. However, the impact of these nanomaterials on human and environmental health is still limited, and concerns regarding the potential risk of exposure during manipulation is constantly rising. Therefore, the extensive use of nanomaterials in the medical field necessitates a comprehensive assessment of their safety and interaction with different tissues of the body system. In this study, we evaluated the systemic toxicity of nanoMIL-89 using Zebrafish embryos as a model system to determine the acute developmental effect. Zebrafish embryos were exposed to a range of nanoMIL-89 concentrations (1 – 300 µM) at 4 h post-fertilization (hpf) for up to 120 hpf. The viability and hatching rate were evaluated at 24–72 hpf, whereas the cardiac function was assessed at 72 and 96 hpf, and the neurodevelopment and hepatic steatosis at 120 hpf. Our study shows that nanoMIL-89 exerted no developmental toxicity on zebrafish embryos at low concentrations (1–10 µM). However, the hatching time and heart development were affected at high concentrations of nanoMIL-89 (> 30 µM). Our findings add novel information into the available data about the in vivo toxicity of nanoMIL-89 and demonstrate its innocuity and safe use in biological, environmental, and medical applications.</p><h2>Other Information</h2> <p> Published in: Toxicology Reports<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.toxrep.2022.04.016" target="_blank">https://dx.doi.org/10.1016/j.toxrep.2022.04.016</a></p>2022-04-20T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.toxrep.2022.04.016https://figshare.com/articles/journal_contribution/Evaluation_of_Metal_Organic_Framework_MIL-89_nanoparticles_toxicity_on_embryonic_zebrafish_development/24745671CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/247456712022-04-20T09:00:00Z |
| spellingShingle | Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development Dana E. Al-Ansari (16327350) Biomedical and clinical sciences Medical biotechnology Engineering Biomedical engineering Nanotechnology Danio rerio Larvae Development Organ toxicity Nanotechnology |
| status_str | publishedVersion |
| title | Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development |
| title_full | Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development |
| title_fullStr | Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development |
| title_full_unstemmed | Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development |
| title_short | Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development |
| title_sort | Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development |
| topic | Biomedical and clinical sciences Medical biotechnology Engineering Biomedical engineering Nanotechnology Danio rerio Larvae Development Organ toxicity Nanotechnology |