Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes
<h3>Aim</h3><p dir="ltr">Cardiac autonomic neuropathy (CAN) has been suggested to be associated with hypoglycemia and impaired hypoglycemia unawareness. We have assessed the relationship between CAN and extensive measures of glucose variability (GV) in patients with type...
محفوظ في:
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| مؤلفون آخرون: | , , , , , , , , , , , , , |
| منشور في: |
2023
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| _version_ | 1864513529513508864 |
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| author | Hoda Gad (6470522) |
| author2 | Einas Elgassim (13036443) Ibrahim Mohammed (4091773) Ahmad Yaser Alhaddad (7017434) Hussein Ahmed Hussein Zaky Aly (17821025) John-John Cabibihan (352200) Abdulaziz Al-Ali (16393288) Kishor Kumar Sadasivuni (8036039) Ioannis N. Petropoulos (8748726) Georgios Ponirakis (803076) Wajeeha Abuhelaiqa (17821028) Amin Jayyousi (3158868) Dabia AlMohanadi (17821031) Khaled Baagar (7487690) Rayaz A. Malik (7372649) |
| author2_role | author author author author author author author author author author author author author author |
| author_facet | Hoda Gad (6470522) Einas Elgassim (13036443) Ibrahim Mohammed (4091773) Ahmad Yaser Alhaddad (7017434) Hussein Ahmed Hussein Zaky Aly (17821025) John-John Cabibihan (352200) Abdulaziz Al-Ali (16393288) Kishor Kumar Sadasivuni (8036039) Ioannis N. Petropoulos (8748726) Georgios Ponirakis (803076) Wajeeha Abuhelaiqa (17821028) Amin Jayyousi (3158868) Dabia AlMohanadi (17821031) Khaled Baagar (7487690) Rayaz A. Malik (7372649) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hoda Gad (6470522) Einas Elgassim (13036443) Ibrahim Mohammed (4091773) Ahmad Yaser Alhaddad (7017434) Hussein Ahmed Hussein Zaky Aly (17821025) John-John Cabibihan (352200) Abdulaziz Al-Ali (16393288) Kishor Kumar Sadasivuni (8036039) Ioannis N. Petropoulos (8748726) Georgios Ponirakis (803076) Wajeeha Abuhelaiqa (17821028) Amin Jayyousi (3158868) Dabia AlMohanadi (17821031) Khaled Baagar (7487690) Rayaz A. Malik (7372649) |
| dc.date.none.fl_str_mv | 2023-05-09T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.diabres.2023.110670 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Cardiovascular_autonomic_neuropathy_is_associated_with_increased_glycemic_variability_driven_by_hyperglycemia_rather_than_hypoglycemia_in_patients_with_diabetes/25036439 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Diabetes Cardiac autonomic neuropathy (CAN) Continuous glucose monitoring (CGM) Hyperglycemia Hypoglycemia |
| dc.title.none.fl_str_mv | Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Aim</h3><p dir="ltr">Cardiac autonomic neuropathy (CAN) has been suggested to be associated with hypoglycemia and impaired hypoglycemia unawareness. We have assessed the relationship between CAN and extensive measures of glucose variability (GV) in patients with type 1 and type 2 diabetes.</p><h3>Methods</h3><p dir="ltr">Participants with diabetes underwent continuous glucose monitoring (CGM) to obtain measures of GV and the extent of hyperglycemia and hypoglycemia and cardiovascular autonomic reflex testing.</p><h3>Results</h3><p dir="ltr">Of the 40 participants (20 T1DM and 20 T2DM) (aged 40.70 ± 13.73 years, diabetes duration 14.43 ± 7.35 years, HbA1c 8.85 ± 1.70%), 23 (57.5%) had CAN. Despite a lower coefficient of variation (CV) (31.26 ± 11.87 vs. 40.33 ± 11.03, P = 0.018), they had a higher CONGA (8.42 ± 2.58 vs. 6.68 ± 1.88, P = 0.024) with a lower median LBGI (1.60 (range: 0.20–3.50) vs. 4.90 (range: 3.20–7.40), P = 0.010) and percentage median time spent in hypoglycemia (4 (range:4–13) vs. 1 (range:0–5), P = 0.008), compared to those without CAN. The percentage GRADEEuglycemia (3.30 ± 2.78 vs. 5.69 ± 3.09, P = 0.017) and GRADEHypoglycemia (0.3 (range: 0 – 3.80) vs. 1.8 (range: 0.9–6.5), P = 0.036) were significantly lower, while the percentage median GRADEHyperglycemia (95.45 (range:93–98) vs. 91.6 (82.8–95.1), P = 0.013) was significantly higher in participants with CAN compared to those without CAN.</p><h3>Conclusion</h3><p dir="ltr">CAN was associated with increased glycemic variability with less time in euglycemia attributed to a greater time in hyperglycemia but not hypoglycemia.</p><h2>Other Information</h2><p dir="ltr">Published in: Diabetes Research and Clinical Practice<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.diabres.2023.110670" target="_blank">https://dx.doi.org/10.1016/j.diabres.2023.110670</a></p><p dir="ltr">Additional institutions affiliated with: National Diabetes Center - HMC</p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ceded0b1949817b93b137ab619b1619d |
| identifier_str_mv | 10.1016/j.diabres.2023.110670 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25036439 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetesHoda Gad (6470522)Einas Elgassim (13036443)Ibrahim Mohammed (4091773)Ahmad Yaser Alhaddad (7017434)Hussein Ahmed Hussein Zaky Aly (17821025)John-John Cabibihan (352200)Abdulaziz Al-Ali (16393288)Kishor Kumar Sadasivuni (8036039)Ioannis N. Petropoulos (8748726)Georgios Ponirakis (803076)Wajeeha Abuhelaiqa (17821028)Amin Jayyousi (3158868)Dabia AlMohanadi (17821031)Khaled Baagar (7487690)Rayaz A. Malik (7372649)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesDiabetesCardiac autonomic neuropathy (CAN)Continuous glucose monitoring (CGM)HyperglycemiaHypoglycemia<h3>Aim</h3><p dir="ltr">Cardiac autonomic neuropathy (CAN) has been suggested to be associated with hypoglycemia and impaired hypoglycemia unawareness. We have assessed the relationship between CAN and extensive measures of glucose variability (GV) in patients with type 1 and type 2 diabetes.</p><h3>Methods</h3><p dir="ltr">Participants with diabetes underwent continuous glucose monitoring (CGM) to obtain measures of GV and the extent of hyperglycemia and hypoglycemia and cardiovascular autonomic reflex testing.</p><h3>Results</h3><p dir="ltr">Of the 40 participants (20 T1DM and 20 T2DM) (aged 40.70 ± 13.73 years, diabetes duration 14.43 ± 7.35 years, HbA1c 8.85 ± 1.70%), 23 (57.5%) had CAN. Despite a lower coefficient of variation (CV) (31.26 ± 11.87 vs. 40.33 ± 11.03, P = 0.018), they had a higher CONGA (8.42 ± 2.58 vs. 6.68 ± 1.88, P = 0.024) with a lower median LBGI (1.60 (range: 0.20–3.50) vs. 4.90 (range: 3.20–7.40), P = 0.010) and percentage median time spent in hypoglycemia (4 (range:4–13) vs. 1 (range:0–5), P = 0.008), compared to those without CAN. The percentage GRADEEuglycemia (3.30 ± 2.78 vs. 5.69 ± 3.09, P = 0.017) and GRADEHypoglycemia (0.3 (range: 0 – 3.80) vs. 1.8 (range: 0.9–6.5), P = 0.036) were significantly lower, while the percentage median GRADEHyperglycemia (95.45 (range:93–98) vs. 91.6 (82.8–95.1), P = 0.013) was significantly higher in participants with CAN compared to those without CAN.</p><h3>Conclusion</h3><p dir="ltr">CAN was associated with increased glycemic variability with less time in euglycemia attributed to a greater time in hyperglycemia but not hypoglycemia.</p><h2>Other Information</h2><p dir="ltr">Published in: Diabetes Research and Clinical Practice<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.diabres.2023.110670" target="_blank">https://dx.doi.org/10.1016/j.diabres.2023.110670</a></p><p dir="ltr">Additional institutions affiliated with: National Diabetes Center - HMC</p>2023-05-09T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.diabres.2023.110670https://figshare.com/articles/journal_contribution/Cardiovascular_autonomic_neuropathy_is_associated_with_increased_glycemic_variability_driven_by_hyperglycemia_rather_than_hypoglycemia_in_patients_with_diabetes/25036439CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/250364392023-05-09T03:00:00Z |
| spellingShingle | Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes Hoda Gad (6470522) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Diabetes Cardiac autonomic neuropathy (CAN) Continuous glucose monitoring (CGM) Hyperglycemia Hypoglycemia |
| status_str | publishedVersion |
| title | Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes |
| title_full | Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes |
| title_fullStr | Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes |
| title_full_unstemmed | Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes |
| title_short | Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes |
| title_sort | Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Diabetes Cardiac autonomic neuropathy (CAN) Continuous glucose monitoring (CGM) Hyperglycemia Hypoglycemia |