Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications
<h3>Purpose</h3><p dir="ltr">Although genetic predisposition and exposure to dietary gluten are considered necessary triggers for the development of coeliac disease, alterations in the gut microbial composition may also contribute towards the pathogenesis of coeliac disea...
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2020
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| _version_ | 1864513566527193088 |
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| author | Anthony K. Akobeng (7713470) |
| author2 | Parul Singh (191877) Manoj Kumar (205700) Souhaila Al Khodor (11657583) |
| author2_role | author author author |
| author_facet | Anthony K. Akobeng (7713470) Parul Singh (191877) Manoj Kumar (205700) Souhaila Al Khodor (11657583) |
| author_role | author |
| dc.creator.none.fl_str_mv | Anthony K. Akobeng (7713470) Parul Singh (191877) Manoj Kumar (205700) Souhaila Al Khodor (11657583) |
| dc.date.none.fl_str_mv | 2020-07-10T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00394-020-02324-y |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Role_of_the_gut_microbiota_in_the_pathogenesis_of_coeliac_disease_and_potential_therapeutic_implications/21601308 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Immunology Coeliac disease Microbiota Metagenomics Dysbiosis |
| dc.title.none.fl_str_mv | Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Purpose</h3><p dir="ltr">Although genetic predisposition and exposure to dietary gluten are considered necessary triggers for the development of coeliac disease, alterations in the gut microbial composition may also contribute towards the pathogenesis of coeliac disease. This review aims to provide an overview of the available data on the potential mechanisms through which the gut microbiota plays a role in the causation of coeliac disease and to discuss the potential therapeutic strategies that could diminish the consequences of microbial dysbiosis.</p><h3>Method</h3><p dir="ltr">A search of the literature was performed using the PubMed, Embase, and JSTOR databases; relevant articles were included.</p><h3>Results</h3><p dir="ltr">Recent studies in patients with coeliac disease have reported an increase in the relative amounts of gram negative bacterial genera such as Bacteroides, Prevotella, and Escherichia, and reduced amounts of protective anti-inflammatory bacteria such as Bifidobacteria and Lactobacilli. Dysbiotic microbiota may lead to a dysregulated immune response that may contribute to the pathogenesis of coeliac disease. In infancy, antibiotic use and certain infant feeding practices may lead to alterations in the developing gut microbiota to influence the immune maturation process and predispose to coeliac disease.</p><h3>Conclusion</h3><p dir="ltr">The induction of the intestinal immune system and gluten intolerance may be influenced by the relative abundance of certain microbiota. Factors such as infant feeding practices, diet, antibiotics, and infections, may be involved in the development of coeliac disease due to their influence on gut microbial composition. The efficacy of potential modulators of the gut microbiota such as probiotics, prebiotics, and fecal microbial transplant as adjunctive treatments to gluten-free diet in coeliac disease is unproven and requires further investigation.</p><h2>Other Information</h2><p dir="ltr">Published in: European Journal of Nutrition<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00394-020-02324-y" target="_blank">http://dx.doi.org/10.1007/s00394-020-02324-y</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_cee085cbef61468de1d5c104d418130f |
| identifier_str_mv | 10.1007/s00394-020-02324-y |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21601308 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implicationsAnthony K. Akobeng (7713470)Parul Singh (191877)Manoj Kumar (205700)Souhaila Al Khodor (11657583)Biomedical and clinical sciencesClinical sciencesImmunologyCoeliac diseaseMicrobiotaMetagenomicsDysbiosis<h3>Purpose</h3><p dir="ltr">Although genetic predisposition and exposure to dietary gluten are considered necessary triggers for the development of coeliac disease, alterations in the gut microbial composition may also contribute towards the pathogenesis of coeliac disease. This review aims to provide an overview of the available data on the potential mechanisms through which the gut microbiota plays a role in the causation of coeliac disease and to discuss the potential therapeutic strategies that could diminish the consequences of microbial dysbiosis.</p><h3>Method</h3><p dir="ltr">A search of the literature was performed using the PubMed, Embase, and JSTOR databases; relevant articles were included.</p><h3>Results</h3><p dir="ltr">Recent studies in patients with coeliac disease have reported an increase in the relative amounts of gram negative bacterial genera such as Bacteroides, Prevotella, and Escherichia, and reduced amounts of protective anti-inflammatory bacteria such as Bifidobacteria and Lactobacilli. Dysbiotic microbiota may lead to a dysregulated immune response that may contribute to the pathogenesis of coeliac disease. In infancy, antibiotic use and certain infant feeding practices may lead to alterations in the developing gut microbiota to influence the immune maturation process and predispose to coeliac disease.</p><h3>Conclusion</h3><p dir="ltr">The induction of the intestinal immune system and gluten intolerance may be influenced by the relative abundance of certain microbiota. Factors such as infant feeding practices, diet, antibiotics, and infections, may be involved in the development of coeliac disease due to their influence on gut microbial composition. The efficacy of potential modulators of the gut microbiota such as probiotics, prebiotics, and fecal microbial transplant as adjunctive treatments to gluten-free diet in coeliac disease is unproven and requires further investigation.</p><h2>Other Information</h2><p dir="ltr">Published in: European Journal of Nutrition<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00394-020-02324-y" target="_blank">http://dx.doi.org/10.1007/s00394-020-02324-y</a></p>2020-07-10T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00394-020-02324-yhttps://figshare.com/articles/journal_contribution/Role_of_the_gut_microbiota_in_the_pathogenesis_of_coeliac_disease_and_potential_therapeutic_implications/21601308CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/216013082020-07-10T06:00:00Z |
| spellingShingle | Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications Anthony K. Akobeng (7713470) Biomedical and clinical sciences Clinical sciences Immunology Coeliac disease Microbiota Metagenomics Dysbiosis |
| status_str | publishedVersion |
| title | Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications |
| title_full | Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications |
| title_fullStr | Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications |
| title_full_unstemmed | Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications |
| title_short | Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications |
| title_sort | Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications |
| topic | Biomedical and clinical sciences Clinical sciences Immunology Coeliac disease Microbiota Metagenomics Dysbiosis |