Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study

<h3>Background</h3><p dir="ltr">Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional coactivator p300, a critic...

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Bibliographic Details
Main Author:	Muhammad Suleman (3829027) (author)
Other Authors:	Abrar Mohammad Sayaf (11644294) (author), Sohail Aftab (22443284) (author), Mohammed Alissa (18607830) (author), Abdullah Alghamdi (14375904) (author), Suad A. Alghamdi (21998691) (author), Mohammed A. Alshehri (18696547) (author), Kar Kheng Yeoh (1933633) (author), Sergio Crovella (20921252) (author), Abdullah Shaito (20545181) (author)
Published:	2025
Subjects:	Biological sciences Biochemistry and cell biology Bioinformatics and computational biology Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry Health sciences Traditional, complementary and integrative medicine p300 HIF-1 hypoxia phytocompounds drug screening MD simulation binding free energy
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Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study

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