Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back
<p dir="ltr">An incidence and mortality of cancer are rapidly growing worldwide, especially due to heterogeneous character of the disease that is associated with irreversible impairment of cellular homeostasis and function. Targeting apoptosis, one of cancer hallmarks, represents a p...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , , , |
| منشور في: |
2020
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513512278065152 |
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| author | Lenka Koklesova (18102994) |
| author2 | Alena Liskova (11008851) Marek Samec (14727823) Constanze Buhrmann (325463) Samson Mathews Samuel (11008848) Elizabeth Varghese (11008845) Milad Ashrafizadeh (12342797) Masoud Najafi (18891724) Mehdi Shakibaei (325455) Dietrich Büsselberg (11008857) Frank A. Giordano (10158842) Olga Golubnitschaja (18891727) Peter Kubatka (11008854) |
| author2_role | author author author author author author author author author author author author |
| author_facet | Lenka Koklesova (18102994) Alena Liskova (11008851) Marek Samec (14727823) Constanze Buhrmann (325463) Samson Mathews Samuel (11008848) Elizabeth Varghese (11008845) Milad Ashrafizadeh (12342797) Masoud Najafi (18891724) Mehdi Shakibaei (325455) Dietrich Büsselberg (11008857) Frank A. Giordano (10158842) Olga Golubnitschaja (18891727) Peter Kubatka (11008854) |
| author_role | author |
| dc.creator.none.fl_str_mv | Lenka Koklesova (18102994) Alena Liskova (11008851) Marek Samec (14727823) Constanze Buhrmann (325463) Samson Mathews Samuel (11008848) Elizabeth Varghese (11008845) Milad Ashrafizadeh (12342797) Masoud Najafi (18891724) Mehdi Shakibaei (325455) Dietrich Büsselberg (11008857) Frank A. Giordano (10158842) Olga Golubnitschaja (18891727) Peter Kubatka (11008854) |
| dc.date.none.fl_str_mv | 2020-08-26T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cancers12092425 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Carotenoids_in_Cancer_Apoptosis_The_Road_from_Bench_to_Bedside_and_Back/26114512 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis carotenoids phytochemicals plant substances apoptosis programmed cell death intrinsic pathway extrinsic pathway anti-cancer therapy chemoprevention nutritional supplement vitamins cancer cells ROS predictive preventive personalized medicine (PPPM/3PM) patient stratification individualized patient profiling complementary medicine targeted treatment nanotechnology bioavailability solubility sensitizers |
| dc.title.none.fl_str_mv | Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">An incidence and mortality of cancer are rapidly growing worldwide, especially due to heterogeneous character of the disease that is associated with irreversible impairment of cellular homeostasis and function. Targeting apoptosis, one of cancer hallmarks, represents a potent cancer treatment strategy. Carotenoids are phytochemicals represented by carotenes, xanthophylls, and derived compounds such as apocarotenoids that demonstrate a broad spectrum of anti-cancer effects involving pro-apoptotic signaling through extrinsic and intrinsic pathways. As demonstrated in preclinical oncology research, the apoptotic modulation is performed at post-genomic levels. Further, carotenoids demonstrate additive/synergistic action in combination with conventional oncostatic agents. In addition, a sensitization of tumor cells to anti-cancer conventional treatment can be achieved by carotenoids. The disadvantage of anti-cancer application of carotenoids is associated with their low solubility and, therefore, poor bioavailability. However, this deficiency can be improved by using nanotechnological approaches, solid dispersions, microemulsions or biofortification that significantly increase the anti-cancer and pro-apoptotic efficacy of carotenoids. Only limited number of studies dealing with apoptotic potential of carotenoids has been published in clinical sphere. Pro-apoptotic effects of carotenoids should be beneficial for individuals at high risk of cancer development. The article considers the utility of carotenoids in the framework of 3P medicine.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancers<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers12092425" target="_blank">https://dx.doi.org/10.3390/cancers12092425</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_cfd95750e596c02466b207354e210f75 |
| identifier_str_mv | 10.3390/cancers12092425 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26114512 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and BackLenka Koklesova (18102994)Alena Liskova (11008851)Marek Samec (14727823)Constanze Buhrmann (325463)Samson Mathews Samuel (11008848)Elizabeth Varghese (11008845)Milad Ashrafizadeh (12342797)Masoud Najafi (18891724)Mehdi Shakibaei (325455)Dietrich Büsselberg (11008857)Frank A. Giordano (10158842)Olga Golubnitschaja (18891727)Peter Kubatka (11008854)Biomedical and clinical sciencesOncology and carcinogenesiscarotenoidsphytochemicalsplant substancesapoptosisprogrammed cell deathintrinsic pathwayextrinsic pathwayanti-cancer therapychemopreventionnutritional supplementvitaminscancer cellsROSpredictive preventive personalized medicine (PPPM/3PM)patient stratificationindividualized patient profilingcomplementary medicinetargeted treatmentnanotechnologybioavailabilitysolubilitysensitizers<p dir="ltr">An incidence and mortality of cancer are rapidly growing worldwide, especially due to heterogeneous character of the disease that is associated with irreversible impairment of cellular homeostasis and function. Targeting apoptosis, one of cancer hallmarks, represents a potent cancer treatment strategy. Carotenoids are phytochemicals represented by carotenes, xanthophylls, and derived compounds such as apocarotenoids that demonstrate a broad spectrum of anti-cancer effects involving pro-apoptotic signaling through extrinsic and intrinsic pathways. As demonstrated in preclinical oncology research, the apoptotic modulation is performed at post-genomic levels. Further, carotenoids demonstrate additive/synergistic action in combination with conventional oncostatic agents. In addition, a sensitization of tumor cells to anti-cancer conventional treatment can be achieved by carotenoids. The disadvantage of anti-cancer application of carotenoids is associated with their low solubility and, therefore, poor bioavailability. However, this deficiency can be improved by using nanotechnological approaches, solid dispersions, microemulsions or biofortification that significantly increase the anti-cancer and pro-apoptotic efficacy of carotenoids. Only limited number of studies dealing with apoptotic potential of carotenoids has been published in clinical sphere. Pro-apoptotic effects of carotenoids should be beneficial for individuals at high risk of cancer development. The article considers the utility of carotenoids in the framework of 3P medicine.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancers<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers12092425" target="_blank">https://dx.doi.org/10.3390/cancers12092425</a></p>2020-08-26T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cancers12092425https://figshare.com/articles/journal_contribution/Carotenoids_in_Cancer_Apoptosis_The_Road_from_Bench_to_Bedside_and_Back/26114512CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/261145122020-08-26T06:00:00Z |
| spellingShingle | Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back Lenka Koklesova (18102994) Biomedical and clinical sciences Oncology and carcinogenesis carotenoids phytochemicals plant substances apoptosis programmed cell death intrinsic pathway extrinsic pathway anti-cancer therapy chemoprevention nutritional supplement vitamins cancer cells ROS predictive preventive personalized medicine (PPPM/3PM) patient stratification individualized patient profiling complementary medicine targeted treatment nanotechnology bioavailability solubility sensitizers |
| status_str | publishedVersion |
| title | Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back |
| title_full | Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back |
| title_fullStr | Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back |
| title_full_unstemmed | Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back |
| title_short | Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back |
| title_sort | Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis carotenoids phytochemicals plant substances apoptosis programmed cell death intrinsic pathway extrinsic pathway anti-cancer therapy chemoprevention nutritional supplement vitamins cancer cells ROS predictive preventive personalized medicine (PPPM/3PM) patient stratification individualized patient profiling complementary medicine targeted treatment nanotechnology bioavailability solubility sensitizers |