Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer
<div><p>Colorectal cancer (CRC) is one of the most common cancers worldwide. The diagnosis, prognosis and therapeutic monitoring of CRC depends largely on tissue biopsy. However, due to tumor heterogeneity and limitations such as invasiveness, high cost and limited applicability in longi...
محفوظ في:
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| مؤلفون آخرون: | , , , , , , , , , , , , , , |
| منشور في: |
2022
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إضافة وسم
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| _version_ | 1864513519127363584 |
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| author | Afsheen Raza (492657) |
| author2 | Abdul Q. Khan (14153247) Varghese Philipose Inchakalody (14153292) Sarra Mestiri (14557379) Zeenath Safira K. M. Yoosuf (15263536) Takwa Bedhiafi (14153460) Dina Moustafa Abo El-Ella (18394866) Nassiba Taib (14557385) Shereena Hydrose (14442135) Shayista Akbar (14442117) Queenie Fernandes (14557388) Lobna Al-Zaidan (14557394) Roopesh Krishnankutty (1297770) Maysaloun Merhi (4246147) Shahab Uddin (154400) Said Dermime (79420) |
| author2_role | author author author author author author author author author author author author author author author |
| author_facet | Afsheen Raza (492657) Abdul Q. Khan (14153247) Varghese Philipose Inchakalody (14153292) Sarra Mestiri (14557379) Zeenath Safira K. M. Yoosuf (15263536) Takwa Bedhiafi (14153460) Dina Moustafa Abo El-Ella (18394866) Nassiba Taib (14557385) Shereena Hydrose (14442135) Shayista Akbar (14442117) Queenie Fernandes (14557388) Lobna Al-Zaidan (14557394) Roopesh Krishnankutty (1297770) Maysaloun Merhi (4246147) Shahab Uddin (154400) Said Dermime (79420) |
| author_role | author |
| dc.creator.none.fl_str_mv | Afsheen Raza (492657) Abdul Q. Khan (14153247) Varghese Philipose Inchakalody (14153292) Sarra Mestiri (14557379) Zeenath Safira K. M. Yoosuf (15263536) Takwa Bedhiafi (14153460) Dina Moustafa Abo El-Ella (18394866) Nassiba Taib (14557385) Shereena Hydrose (14442135) Shayista Akbar (14442117) Queenie Fernandes (14557388) Lobna Al-Zaidan (14557394) Roopesh Krishnankutty (1297770) Maysaloun Merhi (4246147) Shahab Uddin (154400) Said Dermime (79420) |
| dc.date.none.fl_str_mv | 2022-03-15T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s13046-022-02318-0 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Dynamic_liquid_biopsy_components_as_predictive_and_prognostic_biomarkers_in_colorectal_cancer/25624302 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Liquid biopsy Colorectal cancer Microbiome Exosomes Circulating tumor DNA Circulating noncoding RNAs Circulating tumor cells |
| dc.title.none.fl_str_mv | Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Colorectal cancer (CRC) is one of the most common cancers worldwide. The diagnosis, prognosis and therapeutic monitoring of CRC depends largely on tissue biopsy. However, due to tumor heterogeneity and limitations such as invasiveness, high cost and limited applicability in longitudinal monitoring, liquid biopsy has gathered immense attention in CRC. Liquid biopsy has several advantages over tissue biopsy including ease of sampling, effective monitoring, and longitudinal assessment of treatment dynamics. Furthermore, the importance of liquid biopsy is signified by approval of several liquid biopsy assays by regulatory bodies indicating the powerful approach of liquid biopsy for comprehensive CRC screening, diagnostic and prognostics. Several liquid biopsy biomarkers such as novel components of the microbiome, non-coding RNAs, extracellular vesicles and circulating tumor DNA are extensively being researched for their role in CRC management. Majority of these components have shown promising results on their clinical application in CRC including early detection, observe tumor heterogeneity for treatment and response, prediction of metastases and relapse and detection of minimal residual disease. Therefore, in this review, we aim to provide updated information on various novel liquid biopsy markers such as a) oral microbiota related bacterial network b) gut microbiome-associated serum metabolites c) PIWI-interacting RNAs (piRNAs), microRNA(miRNAs), Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and d) circulating tumor DNAs (ctDNA) and circulating tumor cells (CTC) for their role in disease diagnosis, prognosis, treatment monitoring and their applicability for personalized management of CRC.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Experimental & Clinical Cancer Research<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s13046-022-02318-0" target="_blank">https://dx.doi.org/10.1186/s13046-022-02318-0</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d0247844c62acfae69708f84048f788a |
| identifier_str_mv | 10.1186/s13046-022-02318-0 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25624302 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancerAfsheen Raza (492657)Abdul Q. Khan (14153247)Varghese Philipose Inchakalody (14153292)Sarra Mestiri (14557379)Zeenath Safira K. M. Yoosuf (15263536)Takwa Bedhiafi (14153460)Dina Moustafa Abo El-Ella (18394866)Nassiba Taib (14557385)Shereena Hydrose (14442135)Shayista Akbar (14442117)Queenie Fernandes (14557388)Lobna Al-Zaidan (14557394)Roopesh Krishnankutty (1297770)Maysaloun Merhi (4246147)Shahab Uddin (154400)Said Dermime (79420)Biomedical and clinical sciencesOncology and carcinogenesisLiquid biopsyColorectal cancerMicrobiomeExosomesCirculating tumor DNACirculating noncoding RNAsCirculating tumor cells<div><p>Colorectal cancer (CRC) is one of the most common cancers worldwide. The diagnosis, prognosis and therapeutic monitoring of CRC depends largely on tissue biopsy. However, due to tumor heterogeneity and limitations such as invasiveness, high cost and limited applicability in longitudinal monitoring, liquid biopsy has gathered immense attention in CRC. Liquid biopsy has several advantages over tissue biopsy including ease of sampling, effective monitoring, and longitudinal assessment of treatment dynamics. Furthermore, the importance of liquid biopsy is signified by approval of several liquid biopsy assays by regulatory bodies indicating the powerful approach of liquid biopsy for comprehensive CRC screening, diagnostic and prognostics. Several liquid biopsy biomarkers such as novel components of the microbiome, non-coding RNAs, extracellular vesicles and circulating tumor DNA are extensively being researched for their role in CRC management. Majority of these components have shown promising results on their clinical application in CRC including early detection, observe tumor heterogeneity for treatment and response, prediction of metastases and relapse and detection of minimal residual disease. Therefore, in this review, we aim to provide updated information on various novel liquid biopsy markers such as a) oral microbiota related bacterial network b) gut microbiome-associated serum metabolites c) PIWI-interacting RNAs (piRNAs), microRNA(miRNAs), Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and d) circulating tumor DNAs (ctDNA) and circulating tumor cells (CTC) for their role in disease diagnosis, prognosis, treatment monitoring and their applicability for personalized management of CRC.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Experimental & Clinical Cancer Research<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s13046-022-02318-0" target="_blank">https://dx.doi.org/10.1186/s13046-022-02318-0</a></p>2022-03-15T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s13046-022-02318-0https://figshare.com/articles/journal_contribution/Dynamic_liquid_biopsy_components_as_predictive_and_prognostic_biomarkers_in_colorectal_cancer/25624302CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/256243022022-03-15T03:00:00Z |
| spellingShingle | Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer Afsheen Raza (492657) Biomedical and clinical sciences Oncology and carcinogenesis Liquid biopsy Colorectal cancer Microbiome Exosomes Circulating tumor DNA Circulating noncoding RNAs Circulating tumor cells |
| status_str | publishedVersion |
| title | Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer |
| title_full | Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer |
| title_fullStr | Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer |
| title_full_unstemmed | Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer |
| title_short | Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer |
| title_sort | Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Liquid biopsy Colorectal cancer Microbiome Exosomes Circulating tumor DNA Circulating noncoding RNAs Circulating tumor cells |