Cardiovascular Efficacy and Safety of Finerenone: A Meta‐Analysis of Randomized Controlled Trials
<h3>Background</h3><p dir="ltr">Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, has emerged as a novel therapeutic option for the management of patients with diabetes, chronic kidney disease, or heart failure. We seek to summarize the evidence on the dru...
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2025
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| _version_ | 1864513538086666240 |
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| author | Mushood Ahmed (19231379) |
| author2 | Areeba Ahsan (22330525) Aimen Shafiq (21767660) Muhammad Talha Maniya (22045973) Hritvik Jain (19757091) Javed Iqbal (2121922) Muhammad Abdullah Naveed (22330528) Raheel Ahmed (450330) Jamal S. Rana (9182456) Marat Fudim (12051803) Gregg C. Fonarow (8135523) |
| author2_role | author author author author author author author author author author |
| author_facet | Mushood Ahmed (19231379) Areeba Ahsan (22330525) Aimen Shafiq (21767660) Muhammad Talha Maniya (22045973) Hritvik Jain (19757091) Javed Iqbal (2121922) Muhammad Abdullah Naveed (22330528) Raheel Ahmed (450330) Jamal S. Rana (9182456) Marat Fudim (12051803) Gregg C. Fonarow (8135523) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mushood Ahmed (19231379) Areeba Ahsan (22330525) Aimen Shafiq (21767660) Muhammad Talha Maniya (22045973) Hritvik Jain (19757091) Javed Iqbal (2121922) Muhammad Abdullah Naveed (22330528) Raheel Ahmed (450330) Jamal S. Rana (9182456) Marat Fudim (12051803) Gregg C. Fonarow (8135523) |
| dc.date.none.fl_str_mv | 2025-02-06T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/clc.70065 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Cardiovascular_Efficacy_and_Safety_of_Finerenone_A_Meta_Analysis_of_Randomized_Controlled_Trials/30233986 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Health sciences Epidemiology cardiovascular chronic kidney disease finerenone heart failure |
| dc.title.none.fl_str_mv | Cardiovascular Efficacy and Safety of Finerenone: A Meta‐Analysis of Randomized Controlled Trials |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, has emerged as a novel therapeutic option for the management of patients with diabetes, chronic kidney disease, or heart failure. We seek to summarize the evidence on the drug's effectiveness regarding cardiovascular (CV) outcomes.</p><h3>Methods</h3><p dir="ltr">We conducted a literature search of Pubmed, Cochrane CENTRAL, Embase, and ClinicalTrials.gov from inception to September 2024. Trials exploring the effects of finerenone on CV outcomes were extracted and analyzed. The results of pooled analyses were presented as risk ratios (RRs) with 95% confidence intervals (CIs).</p><h3>Results</h3><p dir="ltr">A total of eight trials, incorporating 21 200 patients, were included. The pooled analysis demonstrated a significant reduction in all‐cause death (RR 0.92, 95% CI: 0.85–0.99), major adverse CV events (RR 0.85, 95% CI: 0.81–0.90), heart failure‐related hospitalizations or unplanned hospital visits (RR 0.82, 95% CI: 0.76–0.87) with finerenone administration compared to control. Finerenone use was associated with a trend of reduced risk of CV death without reaching statistical significance (RR 0.90, 95% CI: 0.81–1.00). The risk of myocardial infarction (RR 0.91, 95% CI: 0.74–1.12), adverse events (RR 0.96, 95% CI: 0.89–1.03), adverse events leading to discontinuation (RR 1.06, 95% CI: 0.96–1.17) remained comparable across both groups. However, an increased risk of hyperkalemia (RR 2.07, 95% CI: 1.88–2.27) was observed with finerenone therapy compared to the control group.</p><h3>Conclusion</h3><p dir="ltr">Finerenone administration was associated with improved CV outcomes in the CV‐renmetabolic conditions compared to the control group.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Cardiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/clc.70065" target="_blank">https://dx.doi.org/10.1002/clc.70065</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d093f6b031ea8fb14b831699efc896e0 |
| identifier_str_mv | 10.1002/clc.70065 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30233986 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Cardiovascular Efficacy and Safety of Finerenone: A Meta‐Analysis of Randomized Controlled TrialsMushood Ahmed (19231379)Areeba Ahsan (22330525)Aimen Shafiq (21767660)Muhammad Talha Maniya (22045973)Hritvik Jain (19757091)Javed Iqbal (2121922)Muhammad Abdullah Naveed (22330528)Raheel Ahmed (450330)Jamal S. Rana (9182456)Marat Fudim (12051803)Gregg C. Fonarow (8135523)Biomedical and clinical sciencesCardiovascular medicine and haematologyMedical biochemistry and metabolomicsPharmacology and pharmaceutical sciencesHealth sciencesEpidemiologycardiovascularchronic kidney diseasefinerenoneheart failure<h3>Background</h3><p dir="ltr">Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, has emerged as a novel therapeutic option for the management of patients with diabetes, chronic kidney disease, or heart failure. We seek to summarize the evidence on the drug's effectiveness regarding cardiovascular (CV) outcomes.</p><h3>Methods</h3><p dir="ltr">We conducted a literature search of Pubmed, Cochrane CENTRAL, Embase, and ClinicalTrials.gov from inception to September 2024. Trials exploring the effects of finerenone on CV outcomes were extracted and analyzed. The results of pooled analyses were presented as risk ratios (RRs) with 95% confidence intervals (CIs).</p><h3>Results</h3><p dir="ltr">A total of eight trials, incorporating 21 200 patients, were included. The pooled analysis demonstrated a significant reduction in all‐cause death (RR 0.92, 95% CI: 0.85–0.99), major adverse CV events (RR 0.85, 95% CI: 0.81–0.90), heart failure‐related hospitalizations or unplanned hospital visits (RR 0.82, 95% CI: 0.76–0.87) with finerenone administration compared to control. Finerenone use was associated with a trend of reduced risk of CV death without reaching statistical significance (RR 0.90, 95% CI: 0.81–1.00). The risk of myocardial infarction (RR 0.91, 95% CI: 0.74–1.12), adverse events (RR 0.96, 95% CI: 0.89–1.03), adverse events leading to discontinuation (RR 1.06, 95% CI: 0.96–1.17) remained comparable across both groups. However, an increased risk of hyperkalemia (RR 2.07, 95% CI: 1.88–2.27) was observed with finerenone therapy compared to the control group.</p><h3>Conclusion</h3><p dir="ltr">Finerenone administration was associated with improved CV outcomes in the CV‐renmetabolic conditions compared to the control group.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Cardiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/clc.70065" target="_blank">https://dx.doi.org/10.1002/clc.70065</a></p>2025-02-06T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/clc.70065https://figshare.com/articles/journal_contribution/Cardiovascular_Efficacy_and_Safety_of_Finerenone_A_Meta_Analysis_of_Randomized_Controlled_Trials/30233986CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/302339862025-02-06T03:00:00Z |
| spellingShingle | Cardiovascular Efficacy and Safety of Finerenone: A Meta‐Analysis of Randomized Controlled Trials Mushood Ahmed (19231379) Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Health sciences Epidemiology cardiovascular chronic kidney disease finerenone heart failure |
| status_str | publishedVersion |
| title | Cardiovascular Efficacy and Safety of Finerenone: A Meta‐Analysis of Randomized Controlled Trials |
| title_full | Cardiovascular Efficacy and Safety of Finerenone: A Meta‐Analysis of Randomized Controlled Trials |
| title_fullStr | Cardiovascular Efficacy and Safety of Finerenone: A Meta‐Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Cardiovascular Efficacy and Safety of Finerenone: A Meta‐Analysis of Randomized Controlled Trials |
| title_short | Cardiovascular Efficacy and Safety of Finerenone: A Meta‐Analysis of Randomized Controlled Trials |
| title_sort | Cardiovascular Efficacy and Safety of Finerenone: A Meta‐Analysis of Randomized Controlled Trials |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Health sciences Epidemiology cardiovascular chronic kidney disease finerenone heart failure |