Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates
<p>This was a first-time evaluation that sought to analyze the cost-effectiveness of oral paracetamol and intravenous (IV) indomethacin as alternatives to ibuprofen for PDA in neonates. Decision-analytic, literature-based, economic simulation models were constructed, to follow up the use and c...
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2023
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| _version_ | 1864513529531334656 |
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| author | Samaher Al-Shaibi (14152206) |
| author2 | Dina Abushanab (10696501) Fouad Abounahia (17808698) Ahmed Awaisu (5121473) Daoud Al-Badriyeh (832403) |
| author2_role | author author author author |
| author_facet | Samaher Al-Shaibi (14152206) Dina Abushanab (10696501) Fouad Abounahia (17808698) Ahmed Awaisu (5121473) Daoud Al-Badriyeh (832403) |
| author_role | author |
| dc.creator.none.fl_str_mv | Samaher Al-Shaibi (14152206) Dina Abushanab (10696501) Fouad Abounahia (17808698) Ahmed Awaisu (5121473) Daoud Al-Badriyeh (832403) |
| dc.date.none.fl_str_mv | 2023-09-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.cpcardiol.2023.101751 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Cost-Effectiveness_Analysis_of_Ibuprofen_Versus_Indomethacin_or_Paracetamol_for_the_Treatment_of_Patent_Ductus_Arteriosus_in_Preterm_Neonates/25019981 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Paediatrics Pharmacology and pharmaceutical sciences Economics Applied economics Ibuprofen Versus Indomethacin Paracetamol Treatment Preterm Neonates |
| dc.title.none.fl_str_mv | Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>This was a first-time evaluation that sought to analyze the cost-effectiveness of oral paracetamol and intravenous (IV) indomethacin as alternatives to ibuprofen for PDA in neonates. Decision-analytic, literature-based, economic simulation models were constructed, to follow up the use and consequences of oral/IV ibuprofen versus IV indomethacin, and oral/IV ibuprofen versus oral paracetamol, as first-line therapies for PDA closure. Model outcomes of interest were “success”, defined as PDA closure with/without adverse events, or “failure” due to no response to the first course of treatment, death or premature discontinuation of therapy due to adverse events. Oral ibuprofen is dominant/cost-effective over IV indomethacin in 97.9% of simulated cases, but oral paracetamol was 75.2% dominant/cost-effective over oral ibuprofen. Against IV ibuprofen, IV indomethacin was 55.3% dominant/cost-effective, whereas oral paracetamol was dominant/cost-effective in 98.5% of the cases. Sensitivity analyses confirmed the robustness of the study results. For PDA closure, while IV indomethacin was cost-effective against IV ibuprofen, oral paracetamol was cost-effective against both oral and IV ibuprofen.</p><h2>Other Information</h2> <p> Published in: Current Problems in Cardiology<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cpcardiol.2023.101751" target="_blank">https://dx.doi.org/10.1016/j.cpcardiol.2023.101751</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d0c34807dca21054a5e2b289acd92b94 |
| identifier_str_mv | 10.1016/j.cpcardiol.2023.101751 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25019981 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm NeonatesSamaher Al-Shaibi (14152206)Dina Abushanab (10696501)Fouad Abounahia (17808698)Ahmed Awaisu (5121473)Daoud Al-Badriyeh (832403)Biomedical and clinical sciencesCardiovascular medicine and haematologyPaediatricsPharmacology and pharmaceutical sciencesEconomicsApplied economicsIbuprofen Versus IndomethacinParacetamolTreatmentPreterm Neonates<p>This was a first-time evaluation that sought to analyze the cost-effectiveness of oral paracetamol and intravenous (IV) indomethacin as alternatives to ibuprofen for PDA in neonates. Decision-analytic, literature-based, economic simulation models were constructed, to follow up the use and consequences of oral/IV ibuprofen versus IV indomethacin, and oral/IV ibuprofen versus oral paracetamol, as first-line therapies for PDA closure. Model outcomes of interest were “success”, defined as PDA closure with/without adverse events, or “failure” due to no response to the first course of treatment, death or premature discontinuation of therapy due to adverse events. Oral ibuprofen is dominant/cost-effective over IV indomethacin in 97.9% of simulated cases, but oral paracetamol was 75.2% dominant/cost-effective over oral ibuprofen. Against IV ibuprofen, IV indomethacin was 55.3% dominant/cost-effective, whereas oral paracetamol was dominant/cost-effective in 98.5% of the cases. Sensitivity analyses confirmed the robustness of the study results. For PDA closure, while IV indomethacin was cost-effective against IV ibuprofen, oral paracetamol was cost-effective against both oral and IV ibuprofen.</p><h2>Other Information</h2> <p> Published in: Current Problems in Cardiology<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cpcardiol.2023.101751" target="_blank">https://dx.doi.org/10.1016/j.cpcardiol.2023.101751</a></p>2023-09-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.cpcardiol.2023.101751https://figshare.com/articles/journal_contribution/Cost-Effectiveness_Analysis_of_Ibuprofen_Versus_Indomethacin_or_Paracetamol_for_the_Treatment_of_Patent_Ductus_Arteriosus_in_Preterm_Neonates/25019981CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/250199812023-09-01T00:00:00Z |
| spellingShingle | Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates Samaher Al-Shaibi (14152206) Biomedical and clinical sciences Cardiovascular medicine and haematology Paediatrics Pharmacology and pharmaceutical sciences Economics Applied economics Ibuprofen Versus Indomethacin Paracetamol Treatment Preterm Neonates |
| status_str | publishedVersion |
| title | Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates |
| title_full | Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates |
| title_fullStr | Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates |
| title_full_unstemmed | Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates |
| title_short | Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates |
| title_sort | Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Paediatrics Pharmacology and pharmaceutical sciences Economics Applied economics Ibuprofen Versus Indomethacin Paracetamol Treatment Preterm Neonates |