Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation

Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation

<p dir="ltr">A hybrid pharmacophore model, based on structural motifs previously identified by our team, was employed to generate ligands that simultaneously target COX-2, 15-LOX, and PPARγ in the context of metabolic dysfunction-associated fatty liver disease (MAFLD). Notable COX-2...

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Bibliographic Details
Main Author: Mai S. El-Shoukrofy (19646815) (author)
Other Authors: Azza Ismail (10180577) (author), Reem H. Elhamammy (20448346) (author), Sherien A. Abdelhady (20837720) (author), Rasha Nassra (10180574) (author), Monica S. Makkar (20837723) (author), Mahmoud A. Agami (20837726) (author), Ahmed Wahid (15599036) (author), Hisham A. Nematalla (14798362) (author), Minh Sai (17049279) (author), Daniel Merk (1373682) (author), Ahmed F. El-Yazbi (10180589) (author), Ahmed S.F. Belal (20837729) (author), Ali H. Eid (5461829) (author), Perihan A. Elzahhar (10180568) (author)
Published: 2025
Subjects:
Biomedical and clinical sciences
Medical biochemistry and metabolomics
Pharmacology and pharmaceutical sciences
Thiazolones
PPARγ
COX-2
15-LOX
Multi-targeting
Liver inflammation
Metabolic diseases
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