The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 Subjects

The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 Subjects

<p dir="ltr">Familial hypercholesterolemia (FH) is an inherited disease characterized by reduced efficiency of low-density lipoprotein-cholesterol (LDL-C) removal from the blood and, consequently, an increased risk of life-threatening early cardiovascular complications. In Qatar, the...

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Ilhame Diboun (3522413) (author)
مؤلفون آخرون:	Yasser Al-Sarraj (11721425) (author), Salman M. Toor (8854751) (author), Shaban Mohammed (14150130) (author), Nadeem Qureshi (508036) (author), Moza S. H. Al Hail (18282205) (author), Amin Jayyousi (3158868) (author), Jassim Al Suwaidi (284932) (author), Omar M. E. Albagha (11704871) (author)
منشور في:	2022
الموضوعات:	Biological sciences Genetics Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences dyslipidemias hypercholesterolemia familial hypercholesterolemia monogenic FH LDL-C LDLR
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة

The Digenic Causality in Familial Hypercholesterolemia: Revising the Genotype–Phenotype Correlations of the Disease
حسب: Amina Kamar (295977)
منشور في: (2021)

Pharmacogenomics Variability of Lipid-Lowering Therapies in Familial Hypercholesterolemia
حسب: Nagham N. Hindi (18526815)
منشور في: (2021)

The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019
حسب: Elysia M Alvarez (12229352)
منشور في: (2022)

Assessing the genetic burden of familial hypercholesterolemia in a large middle eastern biobank
حسب: Geethanjali Devadoss Gandhi (14056966)
منشور في: (2022)

Genetic Susceptibility to Arrhythmia Phenotypes in a Middle Eastern Cohort of 14,259 Whole-Genome Sequenced Individuals
حسب: Fatima Qafoud (14778571)
منشور في: (2024)

Functional Characterization of Novel <i>MC4R </i>Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar
حسب: Idris Mohammed (751020)
منشور في: (2023)

Understanding the Genetics of Early-Onset Obesity in a Cohort of Children From Qatar
حسب: Idris Mohammed (751020)
منشور في: (2023)

Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor
حسب: Mahmoud A. Alomari (14780446)
منشور في: (2022)

Whole-genome Sequences of Multidrug-Resistant Escherichia coli
حسب: Khodor, Ragheed R.
منشور في: (2023)

LDL-C Targets in Secondary Prevention: How Low Should We Go?
حسب: Karim Bayoumy (3496688)
منشور في: (2019)

Analysis of 14,392 whole genomes reveals 3.5% of Qataris carry medically actionable variants
حسب: Amal Elfatih (14778550)
منشور في: (2024)

Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of Bone
حسب: Ilhame Diboun (3522413)
منشور في: (2022)

Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight
حسب: Ilhame Diboun (3522413)
منشور في: (2021)

Metabolic profiling of pre-gestational and gestational diabetes mellitus identifies novel predictors of pre-term delivery
حسب: Ilhame Diboun (3522413)
منشور في: (2020)

Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status
حسب: Ilhame Diboun (3522413)
منشور في: (2021)

The difference in attitude between college students and their parents on social life, marriage and vocation. (c1960)
حسب: Shuman, Daad
منشور في: (1960)

Changing family relationships in Sidon as indicated by a study of three generations of mothers and daughters. (c1962)
حسب: Dagher, Salwa Asaad
منشور في: (1962)

Development of family patterns in the Assyrian community. (c1957)
حسب: Jacob, Samira
منشور في: (1957)

Revisiting high-density lipoprotein cholesterol in cardiovascular disease: Is too much of a good thing always a good thing?
حسب: Mohammad Al Zein (20090700)
منشور في: (2024)

Genome sequencing unveils mutational landscape of the familial Mediterranean fever: Potential implications of IL33/ST2 signalling
حسب: Meenakshi Umar (492911)
منشور في: (2020)

Comparative Genome Analysis and Characterization of Salmonella enterica using Whole-Genome Sequencing Approach
حسب: Hdayed, Dana
منشور في: (2020)

Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mice
حسب: Bogachev, Oleg
منشور في: (2011)

Toward a 100,000 Votes Party
حسب: Dibeh, Ghassan
منشور في: (2009)

Disentangling Family Firm Heterogeneity: Evidence from a Cross-Country Analysis
حسب: Arteaga, Rocio
منشور في: (2023)

The Arab Family Strength in Qatar, Jordan, and Tunisia
حسب: Abdallah M. Badahdah (17401325)
منشور في: (2019)

OSRA Grant Cycle 2 Public Reports : Project Title: Factors that influence Qatari Family Stability: Testing a Vulnerability and Resiliency Model
حسب: Abdrabo Soliman (10039181)
منشور في: (2019)

Inflammatory protein signatures in individuals with obesity and metabolic syndrome
حسب: Fayaz Ahmad Mir (11828354)
منشور في: (2023)

Is Revisional Gastric Bypass as Effective as Primary Gastric Bypass for Weight Loss and Improvement of Comorbidities?
حسب: Sama Abdulrazzaq (14151831)
منشور في: (2019)

The development through cooperative planning of a unit on the secondary level entitled "Successful family living". (c1959)
حسب: Bizri, Hiam Ali
منشور في: (1959)

Typing and whole-genome sequencing of Brucella isolated from clinical samples in Lebanon. (c2016)
حسب: Abou Zaki, Natalia
منشور في: (2016)

Whole-Genome Sequence Analysis of Carbapenem-Resistant Enterobacteriaceae Recovered from Hospitalized Patients in Lebanon
حسب: El Khoury, Maria
منشور في: (2020)

Comprehensive whole genome sequence analyses yields novel genetic and structural insights for Intellectual Disability
حسب: Farah R. Zahir (18892108)
منشور في: (2017)

Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health
حسب: Rawan Diab (16941484)
منشور في: (2024)

VEGAWES: variational segmentation on whole exome sequencing for copy number detection
حسب: Samreen Anjum (19651882)
منشور في: (2015)

OSRA Grant Cycle 2 Public Reports : Project Title: Unfamiliar Families: Syrian Refugees’ Transnational Solidarity and Kinship Networks
حسب: Sophie Richter-Devroe (17425422)
منشور في: (2020)

Whole Genome Sequencing, characterization and analysis Of Coronene degrading bacterial strain, Halomonas caseinilytica: A Bioinformatics approach
حسب: unknown
منشور في: (2020)

Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits
حسب: Gaurav Thareja (459188)
منشور في: (2021)

Whole genome sequencing of marine organisms by Oxford Nanopore Technologies: Assessment and optimization of HMW‐DNA extraction protocols
حسب: Sonia Boughattas (508422)
منشور في: (2021)

Whole genome sequencing of extended-spectrum β-lactamase producing Klebsiella pneumoniae isolated from a patient in Lebanon
حسب: Tokajian, Sima
منشور في: (2015)

Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing
حسب: Mohamad Saad (214545)
منشور في: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nckeaq8iq6lf5rrteftagc4qno