Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder
<div><p>Autism-spectrum disorders (ASDs) are developmental disabilities that manifest in early childhood and are characterized by qualitative abnormalities in social behaviors, communication skills, and restrictive or repetitive behaviors. To explore the neurobiological mechanisms in ASD...
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2023
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| _version_ | 1864513533521166336 |
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| author | Sabah Nisar (12561961) |
| author2 | Mohammad Haris (564809) |
| author2_role | author |
| author_facet | Sabah Nisar (12561961) Mohammad Haris (564809) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sabah Nisar (12561961) Mohammad Haris (564809) |
| dc.date.none.fl_str_mv | 2023-04-17T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41380-023-02060-9 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Neuroimaging_genetics_approaches_to_identify_new_biomarkers_for_the_early_diagnosis_of_autism_spectrum_disorder/24935970 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Neurosciences autism-spectrum disorders (ASD) social behaviors communication skills restrictive or repetitive behaviors |
| dc.title.none.fl_str_mv | Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Autism-spectrum disorders (ASDs) are developmental disabilities that manifest in early childhood and are characterized by qualitative abnormalities in social behaviors, communication skills, and restrictive or repetitive behaviors. To explore the neurobiological mechanisms in ASD, extensive research has been done to identify potential diagnostic biomarkers through a neuroimaging genetics approach. Neuroimaging genetics helps to identify ASD-risk genes that contribute to structural and functional variations in brain circuitry and validate biological changes by elucidating the mechanisms and pathways that confer genetic risk. Integrating artificial intelligence models with neuroimaging data lays the groundwork for accurate diagnosis and facilitates the identification of early diagnostic biomarkers for ASD. This review discusses the significance of neuroimaging genetics approaches to gaining a better understanding of the perturbed neurochemical system and molecular pathways in ASD and how these approaches can detect structural, functional, and metabolic changes and lead to the discovery of novel biomarkers for the early diagnosis of ASD.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Molecular Psychiatry<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41380-023-02060-9" target="_blank">https://dx.doi.org/10.1038/s41380-023-02060-9</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d1ed87357e0f6724bd7cf6ff60c430f3 |
| identifier_str_mv | 10.1038/s41380-023-02060-9 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24935970 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorderSabah Nisar (12561961)Mohammad Haris (564809)Biomedical and clinical sciencesClinical sciencesNeurosciencesautism-spectrum disorders (ASD)social behaviorscommunication skillsrestrictive or repetitive behaviors<div><p>Autism-spectrum disorders (ASDs) are developmental disabilities that manifest in early childhood and are characterized by qualitative abnormalities in social behaviors, communication skills, and restrictive or repetitive behaviors. To explore the neurobiological mechanisms in ASD, extensive research has been done to identify potential diagnostic biomarkers through a neuroimaging genetics approach. Neuroimaging genetics helps to identify ASD-risk genes that contribute to structural and functional variations in brain circuitry and validate biological changes by elucidating the mechanisms and pathways that confer genetic risk. Integrating artificial intelligence models with neuroimaging data lays the groundwork for accurate diagnosis and facilitates the identification of early diagnostic biomarkers for ASD. This review discusses the significance of neuroimaging genetics approaches to gaining a better understanding of the perturbed neurochemical system and molecular pathways in ASD and how these approaches can detect structural, functional, and metabolic changes and lead to the discovery of novel biomarkers for the early diagnosis of ASD.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Molecular Psychiatry<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41380-023-02060-9" target="_blank">https://dx.doi.org/10.1038/s41380-023-02060-9</a></p>2023-04-17T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41380-023-02060-9https://figshare.com/articles/journal_contribution/Neuroimaging_genetics_approaches_to_identify_new_biomarkers_for_the_early_diagnosis_of_autism_spectrum_disorder/24935970CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/249359702023-04-17T03:00:00Z |
| spellingShingle | Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder Sabah Nisar (12561961) Biomedical and clinical sciences Clinical sciences Neurosciences autism-spectrum disorders (ASD) social behaviors communication skills restrictive or repetitive behaviors |
| status_str | publishedVersion |
| title | Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder |
| title_full | Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder |
| title_fullStr | Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder |
| title_full_unstemmed | Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder |
| title_short | Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder |
| title_sort | Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder |
| topic | Biomedical and clinical sciences Clinical sciences Neurosciences autism-spectrum disorders (ASD) social behaviors communication skills restrictive or repetitive behaviors |