The diagnostic value of DMSA scan in differentiating functional pseudo-tumors from malignancies in scarred kidneys: case series and literature review
<div><h2>Background</h2> <p>The terms “renal regenerating nodule” and “nodular compensatory hypertrophy” are used in the literature to describe functioning pseudo-tumors (FPT) in the setting of an extensively scarred kidney. FPTs are usually discovered incidentally during rou...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2023
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| _version_ | 1864513533065035776 |
|---|---|
| author | Enas Hussein Mohammed (17733714) |
| author2 | Ahmad Kaddourah (17733717) Noor Al Khori (17733720) Mehdi Djekidel (17733723) |
| author2_role | author author author |
| author_facet | Enas Hussein Mohammed (17733714) Ahmad Kaddourah (17733717) Noor Al Khori (17733720) Mehdi Djekidel (17733723) |
| author_role | author |
| dc.creator.none.fl_str_mv | Enas Hussein Mohammed (17733714) Ahmad Kaddourah (17733717) Noor Al Khori (17733720) Mehdi Djekidel (17733723) |
| dc.date.none.fl_str_mv | 2023-05-26T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12882-023-03113-5 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_diagnostic_value_of_DMSA_scan_in_differentiating_functional_pseudo-tumors_from_malignancies_in_scarred_kidneys_case_series_and_literature_review/24941826 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Renal regenerating nodule Renal pseudo-tumor Chronic kidney disease Dimercaptosuccinic acid scan, DMSA4 Single photon emission computed tomography, SPECT case series |
| dc.title.none.fl_str_mv | The diagnostic value of DMSA scan in differentiating functional pseudo-tumors from malignancies in scarred kidneys: case series and literature review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><h2>Background</h2> <p>The terms “renal regenerating nodule” and “nodular compensatory hypertrophy” are used in the literature to describe functioning pseudo-tumors (FPT) in the setting of an extensively scarred kidney. FPTs are usually discovered incidentally during routine renal imaging. Differentiating these FPTs from renal neoplasms is critical but can be challenging in the setting of chronic kidney disease (CKD) given the limitations related to using contrast-based imaging.</p> <h2>Case summaries</h2> <p>We report a pediatric case series of 5 CKD patients, with history of urinary tract infections, in which tumor-like lesions evolved in scarred kidneys and were incidentally discovered on routine renal imaging. These were diagnosed as FPT by utilizing dimercaptosuccinic acid (DMSA) imaging and showed stable size and appearance upon follow-up with ultrasound and MRI.</p> <h2>Conclusion</h2> <p>FPTs can be picked up on routine imaging of pediatric patients with CKD. Although larger cohort studies are needed to confirm these conclusions, our case series supports the evidence that DMSA scan showing uptake at the site of the mass can be a useful tool to suggest the diagnosis of FPTs in children with kidney scarring, and that SPECT DMSA scan adds more precision in picking up and accurately localizing FPTs compared to planar DMSA.</p> </div><h2>Other Information</h2> <p> Published in: BMC Nephrology<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12882-023-03113-5" target="_blank">https://dx.doi.org/10.1186/s12882-023-03113-5</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d223b0e5ccb20debd1bd035704198bc3 |
| identifier_str_mv | 10.1186/s12882-023-03113-5 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24941826 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The diagnostic value of DMSA scan in differentiating functional pseudo-tumors from malignancies in scarred kidneys: case series and literature reviewEnas Hussein Mohammed (17733714)Ahmad Kaddourah (17733717)Noor Al Khori (17733720)Mehdi Djekidel (17733723)Biomedical and clinical sciencesClinical sciencesRenal regenerating noduleRenal pseudo-tumorChronic kidney diseaseDimercaptosuccinic acid scan, DMSA4Single photon emission computed tomography, SPECTcase series<div><h2>Background</h2> <p>The terms “renal regenerating nodule” and “nodular compensatory hypertrophy” are used in the literature to describe functioning pseudo-tumors (FPT) in the setting of an extensively scarred kidney. FPTs are usually discovered incidentally during routine renal imaging. Differentiating these FPTs from renal neoplasms is critical but can be challenging in the setting of chronic kidney disease (CKD) given the limitations related to using contrast-based imaging.</p> <h2>Case summaries</h2> <p>We report a pediatric case series of 5 CKD patients, with history of urinary tract infections, in which tumor-like lesions evolved in scarred kidneys and were incidentally discovered on routine renal imaging. These were diagnosed as FPT by utilizing dimercaptosuccinic acid (DMSA) imaging and showed stable size and appearance upon follow-up with ultrasound and MRI.</p> <h2>Conclusion</h2> <p>FPTs can be picked up on routine imaging of pediatric patients with CKD. Although larger cohort studies are needed to confirm these conclusions, our case series supports the evidence that DMSA scan showing uptake at the site of the mass can be a useful tool to suggest the diagnosis of FPTs in children with kidney scarring, and that SPECT DMSA scan adds more precision in picking up and accurately localizing FPTs compared to planar DMSA.</p> </div><h2>Other Information</h2> <p> Published in: BMC Nephrology<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12882-023-03113-5" target="_blank">https://dx.doi.org/10.1186/s12882-023-03113-5</a></p>2023-05-26T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12882-023-03113-5https://figshare.com/articles/journal_contribution/The_diagnostic_value_of_DMSA_scan_in_differentiating_functional_pseudo-tumors_from_malignancies_in_scarred_kidneys_case_series_and_literature_review/24941826CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/249418262023-05-26T03:00:00Z |
| spellingShingle | The diagnostic value of DMSA scan in differentiating functional pseudo-tumors from malignancies in scarred kidneys: case series and literature review Enas Hussein Mohammed (17733714) Biomedical and clinical sciences Clinical sciences Renal regenerating nodule Renal pseudo-tumor Chronic kidney disease Dimercaptosuccinic acid scan, DMSA4 Single photon emission computed tomography, SPECT case series |
| status_str | publishedVersion |
| title | The diagnostic value of DMSA scan in differentiating functional pseudo-tumors from malignancies in scarred kidneys: case series and literature review |
| title_full | The diagnostic value of DMSA scan in differentiating functional pseudo-tumors from malignancies in scarred kidneys: case series and literature review |
| title_fullStr | The diagnostic value of DMSA scan in differentiating functional pseudo-tumors from malignancies in scarred kidneys: case series and literature review |
| title_full_unstemmed | The diagnostic value of DMSA scan in differentiating functional pseudo-tumors from malignancies in scarred kidneys: case series and literature review |
| title_short | The diagnostic value of DMSA scan in differentiating functional pseudo-tumors from malignancies in scarred kidneys: case series and literature review |
| title_sort | The diagnostic value of DMSA scan in differentiating functional pseudo-tumors from malignancies in scarred kidneys: case series and literature review |
| topic | Biomedical and clinical sciences Clinical sciences Renal regenerating nodule Renal pseudo-tumor Chronic kidney disease Dimercaptosuccinic acid scan, DMSA4 Single photon emission computed tomography, SPECT case series |