<i>KYNU</i>, a novel potential target that underpins CD44‐promoted breast tumour cell invasion
<p></p><div> <p>Using a validated tetracycline-off-inducible CD44 expression system in mouse model, we have previously demonstrated that the hyaluronan (HA) receptor CD44 promotes breast cancer (BC) metastasis to the liver. To unravel the mechanisms that underpin CD44-promote...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2023
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| _version_ | 1864513566196891648 |
|---|---|
| author | Maryam Al‐Mansoob (14779411) |
| author2 | Ishita Gupta (9203073) Radoslaw Stefan Rusyniak (14779414) Allal Ouhtit (14153256) |
| author2_role | author author author |
| author_facet | Maryam Al‐Mansoob (14779411) Ishita Gupta (9203073) Radoslaw Stefan Rusyniak (14779414) Allal Ouhtit (14153256) |
| author_role | author |
| dc.creator.none.fl_str_mv | Maryam Al‐Mansoob (14779411) Ishita Gupta (9203073) Radoslaw Stefan Rusyniak (14779414) Allal Ouhtit (14153256) |
| dc.date.none.fl_str_mv | 2023-03-15T11:13:53Z |
| dc.identifier.none.fl_str_mv | 10.1111/jcmm.16296 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/_i_KYNU_i_a_novel_potential_target_that_underpins_CD44_promoted_breast_tumour_cell_invasion/22258552 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Cell Biology Molecular Medicine |
| dc.title.none.fl_str_mv | <i>KYNU</i>, a novel potential target that underpins CD44‐promoted breast tumour cell invasion |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p></p><div> <p>Using a validated tetracycline-off-inducible CD44 expression system in mouse model, we have previously demonstrated that the hyaluronan (HA) receptor CD44 promotes breast cancer (BC) metastasis to the liver. To unravel the mechanisms that underpin CD44-promoted BC cell invasion, RNA samples were isolated from two cell models: (a) a tetracycline (Tet)-Off-regulated expression system of the CD44s in MCF-7 cells and; (b) as a complementary approach, the highly metastatic BC cells, MDA-MB-231, were cultured in the presence and absence of 50 µg/mL of HA. Kynureninase (<i>KYNU</i>), identified by Microarray analysis, was up-regulated by 3-fold upon induction and activation of CD44 by HA; this finding suggests that <i>KYNU</i> is a potential novel transcriptional target of CD44-downtstream signalling. KYNU is a pyridoxal phosphate (PLP) dependent enzyme involved in the biosynthesis of NAD cofactors from tryptophan that has been associated with the onset and development of BC. This review will attempt to identify and discuss the findings supporting this hypothesis and the mechanisms linking <i>KYNU</i> cell invasion <i>via</i> CD44.</p> </div><p></p><h2>Other Information</h2> <p> Published in: Journal of Cellular and Molecular Medicine<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1111/jcmm.16296" target="_blank">http://dx.doi.org/10.1111/jcmm.16296</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d2e5845ed6e2d465c895df4287b0aa67 |
| identifier_str_mv | 10.1111/jcmm.16296 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22258552 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | <i>KYNU</i>, a novel potential target that underpins CD44‐promoted breast tumour cell invasionMaryam Al‐Mansoob (14779411)Ishita Gupta (9203073)Radoslaw Stefan Rusyniak (14779414)Allal Ouhtit (14153256)Biomedical and clinical sciencesOncology and carcinogenesisCell BiologyMolecular Medicine<p></p><div> <p>Using a validated tetracycline-off-inducible CD44 expression system in mouse model, we have previously demonstrated that the hyaluronan (HA) receptor CD44 promotes breast cancer (BC) metastasis to the liver. To unravel the mechanisms that underpin CD44-promoted BC cell invasion, RNA samples were isolated from two cell models: (a) a tetracycline (Tet)-Off-regulated expression system of the CD44s in MCF-7 cells and; (b) as a complementary approach, the highly metastatic BC cells, MDA-MB-231, were cultured in the presence and absence of 50 µg/mL of HA. Kynureninase (<i>KYNU</i>), identified by Microarray analysis, was up-regulated by 3-fold upon induction and activation of CD44 by HA; this finding suggests that <i>KYNU</i> is a potential novel transcriptional target of CD44-downtstream signalling. KYNU is a pyridoxal phosphate (PLP) dependent enzyme involved in the biosynthesis of NAD cofactors from tryptophan that has been associated with the onset and development of BC. This review will attempt to identify and discuss the findings supporting this hypothesis and the mechanisms linking <i>KYNU</i> cell invasion <i>via</i> CD44.</p> </div><p></p><h2>Other Information</h2> <p> Published in: Journal of Cellular and Molecular Medicine<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1111/jcmm.16296" target="_blank">http://dx.doi.org/10.1111/jcmm.16296</a></p>2023-03-15T11:13:53ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/jcmm.16296https://figshare.com/articles/journal_contribution/_i_KYNU_i_a_novel_potential_target_that_underpins_CD44_promoted_breast_tumour_cell_invasion/22258552CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/222585522023-03-15T11:13:53Z |
| spellingShingle | <i>KYNU</i>, a novel potential target that underpins CD44‐promoted breast tumour cell invasion Maryam Al‐Mansoob (14779411) Biomedical and clinical sciences Oncology and carcinogenesis Cell Biology Molecular Medicine |
| status_str | publishedVersion |
| title | <i>KYNU</i>, a novel potential target that underpins CD44‐promoted breast tumour cell invasion |
| title_full | <i>KYNU</i>, a novel potential target that underpins CD44‐promoted breast tumour cell invasion |
| title_fullStr | <i>KYNU</i>, a novel potential target that underpins CD44‐promoted breast tumour cell invasion |
| title_full_unstemmed | <i>KYNU</i>, a novel potential target that underpins CD44‐promoted breast tumour cell invasion |
| title_short | <i>KYNU</i>, a novel potential target that underpins CD44‐promoted breast tumour cell invasion |
| title_sort | <i>KYNU</i>, a novel potential target that underpins CD44‐promoted breast tumour cell invasion |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Cell Biology Molecular Medicine |