The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review
<h3>Objective</h3><p dir="ltr">To investigate the optimal route of progesterone administration for luteal phase support in a frozen embryo transfer.</p><h3>Design</h3><p dir="ltr">Systematic review.</p><h3>Patients</h3>&...
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2022
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| _version_ | 1864513568038191104 |
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| author | Abdulla Almohammadi (14158848) |
| author2 | Ainharan Raveendran (6834528) Mairead Black (3179880) Abha Maheshwari (493389) |
| author2_role | author author author |
| author_facet | Abdulla Almohammadi (14158848) Ainharan Raveendran (6834528) Mairead Black (3179880) Abha Maheshwari (493389) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdulla Almohammadi (14158848) Ainharan Raveendran (6834528) Mairead Black (3179880) Abha Maheshwari (493389) |
| dc.date.none.fl_str_mv | 2022-08-09T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00404-022-06674-2 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_optimal_route_of_progesterone_administration_for_luteal_phase_support_in_a_frozen_embryo_transfer_a_systematic_review/21597036 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Reproductive medicine Obstetrics and Gynecology Frozen embryo transfer Progesterone Live birth Miscarriage |
| dc.title.none.fl_str_mv | The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Objective</h3><p dir="ltr">To investigate the optimal route of progesterone administration for luteal phase support in a frozen embryo transfer.</p><h3>Design</h3><p dir="ltr">Systematic review.</p><h3>Patients</h3><p dir="ltr">Women undergoing frozen embryo transfer (FET).</p><h3>Interventions</h3><p dir="ltr">We conducted an extensive database search of Medline (PubMed), Embase, Web of Science, and Cochrane Trials Register using relevant keywords and their combinations to find randomized controlled trials (RCTs) comparing the routes (i.e., oral, vaginal, intramuscular) of progesterone administration for luteal phase support (LPS) in artificial FET.</p><h3>Main outcome measures</h3><p dir="ltr">Clinical pregnancy, live birth, miscarriage.</p><h3>Results</h3><p dir="ltr">Four RCTs with 3245 participants undergoing artificial endometrial preparation (EP) cycles during FET were found to be eligible. Four trials compared vaginal progesterone with intramuscular progesterone and two trials compared vaginal progesterone with oral progesterone. One study favored of vaginal versus oral progesterone for clinical pregnancy rates (RR 0.45, 95% CI 0.22–0.92) and other study favored intramuscular versus vaginal progesterone for clinical pregnancy rates (RR 1.46, 95% CI 1.21–1.76) and live birth rates (RR 1.62, 95% CI 1.28–2.05). Tabulation of overall evidence strength assessment showed low-quality evidence on the basis that for each outcome-comparison pair, there were deficiencies in either directness of outcome measurement or study quality.</p><h3>Conclusion</h3><p dir="ltr">There was little consensus and evidence was heterogeneous on the optimal route of administration of progesterone for LPS during FET in artificial EP cycles. This warrants more trials, indirect comparisons, and network meta-analyses.</p><h3>PROPERO No</h3><p dir="ltr">CRD42021251017.</p><h2>Other Information</h2><p dir="ltr">Published in: Archives of Gynecology and Obstetrics<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00404-022-06674-2" target="_blank">http://dx.doi.org/10.1007/s00404-022-06674-2</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d3728bdc52f6b4d2767a4dcc6655eee3 |
| identifier_str_mv | 10.1007/s00404-022-06674-2 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21597036 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic reviewAbdulla Almohammadi (14158848)Ainharan Raveendran (6834528)Mairead Black (3179880)Abha Maheshwari (493389)Biomedical and clinical sciencesClinical sciencesPharmacology and pharmaceutical sciencesReproductive medicineObstetrics and GynecologyFrozen embryo transferProgesteroneLive birthMiscarriage<h3>Objective</h3><p dir="ltr">To investigate the optimal route of progesterone administration for luteal phase support in a frozen embryo transfer.</p><h3>Design</h3><p dir="ltr">Systematic review.</p><h3>Patients</h3><p dir="ltr">Women undergoing frozen embryo transfer (FET).</p><h3>Interventions</h3><p dir="ltr">We conducted an extensive database search of Medline (PubMed), Embase, Web of Science, and Cochrane Trials Register using relevant keywords and their combinations to find randomized controlled trials (RCTs) comparing the routes (i.e., oral, vaginal, intramuscular) of progesterone administration for luteal phase support (LPS) in artificial FET.</p><h3>Main outcome measures</h3><p dir="ltr">Clinical pregnancy, live birth, miscarriage.</p><h3>Results</h3><p dir="ltr">Four RCTs with 3245 participants undergoing artificial endometrial preparation (EP) cycles during FET were found to be eligible. Four trials compared vaginal progesterone with intramuscular progesterone and two trials compared vaginal progesterone with oral progesterone. One study favored of vaginal versus oral progesterone for clinical pregnancy rates (RR 0.45, 95% CI 0.22–0.92) and other study favored intramuscular versus vaginal progesterone for clinical pregnancy rates (RR 1.46, 95% CI 1.21–1.76) and live birth rates (RR 1.62, 95% CI 1.28–2.05). Tabulation of overall evidence strength assessment showed low-quality evidence on the basis that for each outcome-comparison pair, there were deficiencies in either directness of outcome measurement or study quality.</p><h3>Conclusion</h3><p dir="ltr">There was little consensus and evidence was heterogeneous on the optimal route of administration of progesterone for LPS during FET in artificial EP cycles. This warrants more trials, indirect comparisons, and network meta-analyses.</p><h3>PROPERO No</h3><p dir="ltr">CRD42021251017.</p><h2>Other Information</h2><p dir="ltr">Published in: Archives of Gynecology and Obstetrics<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00404-022-06674-2" target="_blank">http://dx.doi.org/10.1007/s00404-022-06674-2</a></p>2022-08-09T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00404-022-06674-2https://figshare.com/articles/journal_contribution/The_optimal_route_of_progesterone_administration_for_luteal_phase_support_in_a_frozen_embryo_transfer_a_systematic_review/21597036CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215970362022-08-09T06:00:00Z |
| spellingShingle | The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review Abdulla Almohammadi (14158848) Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Reproductive medicine Obstetrics and Gynecology Frozen embryo transfer Progesterone Live birth Miscarriage |
| status_str | publishedVersion |
| title | The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review |
| title_full | The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review |
| title_fullStr | The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review |
| title_full_unstemmed | The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review |
| title_short | The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review |
| title_sort | The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review |
| topic | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Reproductive medicine Obstetrics and Gynecology Frozen embryo transfer Progesterone Live birth Miscarriage |