Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies
<p dir="ltr">A diabetic wound exemplifies the challenge of chronic, nonhealing wounds. Elevated blood sugar levels in diabetes profoundly disrupt macrophage function, impairing crucial activities such as phagocytosis, immune response, cell migration, and blood vessel formation, all e...
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2024
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| _version_ | 1864513541490343936 |
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| author | Nouf N. Mahmoud (9133074) |
| author2 | Salma Hamad (22046837) Sawsan Shraim (22046840) |
| author2_role | author author |
| author_facet | Nouf N. Mahmoud (9133074) Salma Hamad (22046837) Sawsan Shraim (22046840) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nouf N. Mahmoud (9133074) Salma Hamad (22046837) Sawsan Shraim (22046840) |
| dc.date.none.fl_str_mv | 2024-11-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1021/acsomega.4c02251 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Inflammation-Modulating_Biomedical_Interventions_for_Diabetic_Wound_Healing_An_Overview_of_Preclinical_and_Clinical_Studies/29899868 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Immunology Medical biochemistry and metabolomics Biopolymers Immunology Inflammation Peptides and proteins Wound healing |
| dc.title.none.fl_str_mv | Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">A diabetic wound exemplifies the challenge of chronic, nonhealing wounds. Elevated blood sugar levels in diabetes profoundly disrupt macrophage function, impairing crucial activities such as phagocytosis, immune response, cell migration, and blood vessel formation, all essential for effective wound healing. Moreover, the persistent presence of pro-inflammatory cytokines and reactive oxygen species, coupled with a decrease in anti-inflammatory factors, exacerbates the delay in wound healing associated with diabetes. This review emphasizes the dysfunctional inflammatory responses underlying diabetic wounds and explores preclinical studies of inflammation-modulating bioactives and biomaterials that show promise in expediting diabetic wound healing. Additionally, this review provides an overview of selected clinical studies employing biomaterials and bioactive molecules, shedding light on the gap between extensive preclinical research and limited clinical studies in this field.</p><h2>Other Information</h2><p dir="ltr">Published in: ACS Omega<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1021/acsomega.4c02251" target="_blank">https://dx.doi.org/10.1021/acsomega.4c02251</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d39c25f68c2aa6af24806ff8cde3ee58 |
| identifier_str_mv | 10.1021/acsomega.4c02251 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29899868 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical StudiesNouf N. Mahmoud (9133074)Salma Hamad (22046837)Sawsan Shraim (22046840)Biomedical and clinical sciencesClinical sciencesImmunologyMedical biochemistry and metabolomicsBiopolymersImmunologyInflammationPeptides and proteinsWound healing<p dir="ltr">A diabetic wound exemplifies the challenge of chronic, nonhealing wounds. Elevated blood sugar levels in diabetes profoundly disrupt macrophage function, impairing crucial activities such as phagocytosis, immune response, cell migration, and blood vessel formation, all essential for effective wound healing. Moreover, the persistent presence of pro-inflammatory cytokines and reactive oxygen species, coupled with a decrease in anti-inflammatory factors, exacerbates the delay in wound healing associated with diabetes. This review emphasizes the dysfunctional inflammatory responses underlying diabetic wounds and explores preclinical studies of inflammation-modulating bioactives and biomaterials that show promise in expediting diabetic wound healing. Additionally, this review provides an overview of selected clinical studies employing biomaterials and bioactive molecules, shedding light on the gap between extensive preclinical research and limited clinical studies in this field.</p><h2>Other Information</h2><p dir="ltr">Published in: ACS Omega<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1021/acsomega.4c02251" target="_blank">https://dx.doi.org/10.1021/acsomega.4c02251</a></p>2024-11-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1021/acsomega.4c02251https://figshare.com/articles/journal_contribution/Inflammation-Modulating_Biomedical_Interventions_for_Diabetic_Wound_Healing_An_Overview_of_Preclinical_and_Clinical_Studies/29899868CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/298998682024-11-01T00:00:00Z |
| spellingShingle | Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies Nouf N. Mahmoud (9133074) Biomedical and clinical sciences Clinical sciences Immunology Medical biochemistry and metabolomics Biopolymers Immunology Inflammation Peptides and proteins Wound healing |
| status_str | publishedVersion |
| title | Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies |
| title_full | Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies |
| title_fullStr | Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies |
| title_full_unstemmed | Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies |
| title_short | Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies |
| title_sort | Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies |
| topic | Biomedical and clinical sciences Clinical sciences Immunology Medical biochemistry and metabolomics Biopolymers Immunology Inflammation Peptides and proteins Wound healing |