Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

<p dir="ltr">The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide associati...

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Ioanna Ntalla (174685) (author)
مؤلفون آخرون:	Lu-Chen Weng (211804) (author), James H. Cartwright (19694482) (author), Amelia Weber Hall (14930517) (author), Gardar Sveinbjornsson (3820882) (author), Nathan R. Tucker (19694485) (author), Seung Hoan Choi (8174103) (author), Mark D. Chaffin (19694488) (author), Carolina Roselli (3097968) (author), Michael R. Barnes (13158387) (author), Borbala Mifsud (3907267) (author), Helen R. Warren (5410760) (author), Caroline Hayward (149856) (author), Jonathan Marten (3819643) (author), James J. Cranley (19694491) (author), Maria Pina Concas (12643515) (author), Paolo Gasparini (139832) (author), Thibaud Boutin (3819655) (author), Ivana Kolcic (3212697) (author), Ozren Polasek (3965693) (author), Igor Rudan (150101) (author), Nathalia M. Araujo (19694494) (author), Maria Fernanda Lima-Costa (7232726) (author), Antonio Luiz P. Ribeiro (4033124) (author), Renan P. Souza (7955432) (author), Eduardo Tarazona-Santos (145092) (author), Vilmantas Giedraitis (459517) (author), Erik Ingelsson (232651) (author), Anubha Mahajan (206768) (author), Andrew P. Morris (6733298) (author), Fabiola Del Greco M (7635680) (author), Luisa Foco (43249) (author), Martin Gögele (76513) (author), Andrew A. Hicks (7692995) (author), James P. Cook (7643396) (author), Lars Lind (88400) (author), Cecilia M. Lindgren (7541750) (author), Johan Sundström (232655) (author), Christopher P. Nelson (7625975) (author), Muhammad B. Riaz (19694497) (author), Nilesh J. Samani (7579793) (author), Gianfranco Sinagra (290352) (author), Sheila Ulivi (149860) (author), Mika Kähönen (131499) (author), Pashupati P. Mishra (6642206) (author), Nina Mononen (186361) (author), Kjell Nikus (819433) (author), Mark J. Caulfield (7588472) (author), Anna Dominiczak (262121) (author), Sandosh Padmanabhan (238533) (author), May E. Montasser (12109907) (author), Jeff R. O’Connell (19694500) (author), Kathleen Ryan (2930367) (author), Alan R. Shuldiner (12258643) (author), Stefanie Aeschbacher (3164868) (author), David Conen (191914) (author), Lorenz Risch (430248) (author), Sébastien Thériault (11965445) (author), Nina Hutri-Kähönen (186365) (author), Terho Lehtimäki (49739) (author), Leo-Pekka Lyytikäinen (144253) (author), Olli T. Raitakari (7588757) (author), Catriona L. K. Barnes (17094837) (author), Harry Campbell (30339) (author), Peter K. Joshi (7693739) (author), James F. Wilson (7638917) (author), Aaron Isaacs (174648) (author), Jan A. Kors (7464284) (author), Cornelia M. van Duijn (7692962) (author), Paul L. Huang (7743164) (author), Vilmundur Gudnason (8873) (author), Tamara B. Harris (7240184) (author), Lenore J. Launer (7305602) (author), Albert V. Smith (7634078) (author), Erwin P. Bottinger (3212694) (author), Ruth J. F. Loos (6733301) (author), Girish N. Nadkarni (3044592) (author), Michael H. Preuss (15222119) (author), Adolfo Correa (610800) (author), Hao Mei (73778) (author), James Wilson (302768) (author), Thomas Meitinger (26605) (author), Martina Müller-Nurasyid (193464) (author), Annette Peters (62601) (author), Melanie Waldenberger (236985) (author), Massimo Mangino (87550) (author), Timothy D. Spector (7634159) (author), Michiel Rienstra (3342875) (author), Yordi J. van de Vegte (19694503) (author), Pim van der Harst (65060) (author), Niek Verweij (128858) (author), Stefan Kääb (244969) (author), Katharina Schramm (528479) (author), Moritz F. Sinner (7743176) (author), Konstantin Strauch (73658) (author), Michael J. Cutler (11604855) (author), Diane Fatkin (185703) (author), Barry London (7391456) (author), Morten Olesen (10151895) (author), Dan M. Roden (6830087) (author), M. Benjamin Shoemaker (19694506) (author), J. Gustav Smith (162179) (author), Mary L. Biggs (11068021) (author), Joshua C. Bis (7692986) (author), Jennifer A. Brody (7743146) (author), Bruce M. Psaty (7634144) (author), Kenneth Rice (211836) (author), Nona Sotoodehnia (143373) (author), Alessandro De Grandi (76509) (author), Christian Fuchsberger (76512) (author), Cristian Pattaro (65825) (author), Peter P. Pramstaller (7656497) (author), Ian Ford (30666) (author), J. Wouter Jukema (127361) (author), Peter W. Macfarlane (7473807) (author), Stella Trompet (174901) (author), Marcus Dörr (112711) (author), Stephan B. Felix (112722) (author), Uwe Völker (112748) (author), Stefan Weiss (1474864) (author), Aki S. Havulinna (7517390) (author), Antti Jula (37961) (author), Katri Sääksjärvi (19694509) (author), Veikko Salomaa (62543) (author), Xiuqing Guo (73591) (author), Susan R. Heckbert (7634165) (author), Henry J. Lin (6894089) (author), Jerome I. Rotter (7634114) (author), Kent D. Taylor (7743188) (author), Jie Yao (1440151) (author), Renée de Mutsert (561980) (author), Arie C. Maan (7473804) (author), Dennis O. Mook-Kanamori (148319) (author), Raymond Noordam (333224) (author), Francesco Cucca (145742) (author), Jun Ding (80820) (author), Edward G. Lakatta (6849425) (author), Yong Qian (2377) (author), Kirill V. Tarasov (6849404) (author), Daniel Levy (51573) (author), Honghuang Lin (560598) (author), Christopher H. Newton-Cheh (19694512) (author), Kathryn L. Lunetta (8377740) (author), Alison D. Murray (7743173) (author), David J. Porteous (107720) (author), Blair H. Smith (7726100) (author), Bruno H. Stricker (7464293) (author), André Uitterlinden (150139) (author), Marten E. van den Berg (3921611) (author), Jeffrey Haessler (169224) (author), Rebecca D. Jackson (7802564) (author), Charles Kooperberg (18693) (author), Ulrike Peters (101963) (author), Alexander P. Reiner (8174154) (author), Eric A. Whitsel (7370528) (author), Alvaro Alonso (211735) (author), Dan E. Arking (7588586) (author), Eric Boerwinkle (36288) (author), Georg B. Ehret (19694515) (author), Elsayed Z. Soliman (7743179) (author), Christy L. Avery (8207355) (author), Stephanie M. Gogarten (11068024) (author), Kathleen F. Kerr (9396380) (author), Cathy C. Laurie (7634123) (author), Amanda A. Seyerle (5574107) (author), Adrienne Stilp (15178383) (author), Solmaz Assa (739012) (author), M. Abdullah Said (19694518) (author), M. Yldau van der Ende (19694521) (author), Pier D. Lambiase (10163594) (author), Michele Orini (3097818) (author), Julia Ramirez (2614513) (author), Stefan Van Duijvenboden (5520155) (author), David O. Arnar (19694524) (author), Daniel F. Gudbjartsson (14905953) (author), Hilma Holm (181947) (author), Patrick Sulem (57401) (author), Gudmar Thorleifsson (156887) (author), Rosa B. Thorolfsdottir (19694527) (author), Unnur Thorsteinsdottir (49155) (author), Emelia J. Benjamin (7245926) (author), Andrew Tinker (477693) (author), Kari Stefansson (26484) (author), Patrick T. Ellinor (7743158) (author), Yalda Jamshidi (262159) (author), Steven A. Lubitz (7743194) (author), Patricia B. Munroe (7588601) (author)
منشور في:	2020
الموضوعات:	Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Electrocardiogram (ECG) PR interval Atrioventricular conduction Genome-wide association study (GWAS) Polygenic risk Cardiovascular disease Atrial fibrillation (AF) Heart block Cardiac muscle development Multi-ancestry Polygenic predisposition UK Biobank Cardiovascular genetics
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

_version_	1864513557189623808
author	Ioanna Ntalla (174685)
author2	Lu-Chen Weng (211804) James H. Cartwright (19694482) Amelia Weber Hall (14930517) Gardar Sveinbjornsson (3820882) Nathan R. Tucker (19694485) Seung Hoan Choi (8174103) Mark D. Chaffin (19694488) Carolina Roselli (3097968) Michael R. Barnes (13158387) Borbala Mifsud (3907267) Helen R. Warren (5410760) Caroline Hayward (149856) Jonathan Marten (3819643) James J. Cranley (19694491) Maria Pina Concas (12643515) Paolo Gasparini (139832) Thibaud Boutin (3819655) Ivana Kolcic (3212697) Ozren Polasek (3965693) Igor Rudan (150101) Nathalia M. Araujo (19694494) Maria Fernanda Lima-Costa (7232726) Antonio Luiz P. Ribeiro (4033124) Renan P. Souza (7955432) Eduardo Tarazona-Santos (145092) Vilmantas Giedraitis (459517) Erik Ingelsson (232651) Anubha Mahajan (206768) Andrew P. Morris (6733298) Fabiola Del Greco M (7635680) Luisa Foco (43249) Martin Gögele (76513) Andrew A. Hicks (7692995) James P. Cook (7643396) Lars Lind (88400) Cecilia M. Lindgren (7541750) Johan Sundström (232655) Christopher P. Nelson (7625975) Muhammad B. Riaz (19694497) Nilesh J. Samani (7579793) Gianfranco Sinagra (290352) Sheila Ulivi (149860) Mika Kähönen (131499) Pashupati P. Mishra (6642206) Nina Mononen (186361) Kjell Nikus (819433) Mark J. Caulfield (7588472) Anna Dominiczak (262121) Sandosh Padmanabhan (238533) May E. Montasser (12109907) Jeff R. O’Connell (19694500) Kathleen Ryan (2930367) Alan R. Shuldiner (12258643) Stefanie Aeschbacher (3164868) David Conen (191914) Lorenz Risch (430248) Sébastien Thériault (11965445) Nina Hutri-Kähönen (186365) Terho Lehtimäki (49739) Leo-Pekka Lyytikäinen (144253) Olli T. Raitakari (7588757) Catriona L. K. Barnes (17094837) Harry Campbell (30339) Peter K. Joshi (7693739) James F. Wilson (7638917) Aaron Isaacs (174648) Jan A. Kors (7464284) Cornelia M. van Duijn (7692962) Paul L. Huang (7743164) Vilmundur Gudnason (8873) Tamara B. Harris (7240184) Lenore J. Launer (7305602) Albert V. Smith (7634078) Erwin P. Bottinger (3212694) Ruth J. F. Loos (6733301) Girish N. Nadkarni (3044592) Michael H. Preuss (15222119) Adolfo Correa (610800) Hao Mei (73778) James Wilson (302768) Thomas Meitinger (26605) Martina Müller-Nurasyid (193464) Annette Peters (62601) Melanie Waldenberger (236985) Massimo Mangino (87550) Timothy D. Spector (7634159) Michiel Rienstra (3342875) Yordi J. van de Vegte (19694503) Pim van der Harst (65060) Niek Verweij (128858) Stefan Kääb (244969) Katharina Schramm (528479) Moritz F. Sinner (7743176) Konstantin Strauch (73658) Michael J. Cutler (11604855) Diane Fatkin (185703) Barry London (7391456) Morten Olesen (10151895) Dan M. Roden (6830087) M. Benjamin Shoemaker (19694506) J. Gustav Smith (162179) Mary L. Biggs (11068021) Joshua C. Bis (7692986) Jennifer A. Brody (7743146) Bruce M. Psaty (7634144) Kenneth Rice (211836) Nona Sotoodehnia (143373) Alessandro De Grandi (76509) Christian Fuchsberger (76512) Cristian Pattaro (65825) Peter P. Pramstaller (7656497) Ian Ford (30666) J. Wouter Jukema (127361) Peter W. Macfarlane (7473807) Stella Trompet (174901) Marcus Dörr (112711) Stephan B. Felix (112722) Uwe Völker (112748) Stefan Weiss (1474864) Aki S. Havulinna (7517390) Antti Jula (37961) Katri Sääksjärvi (19694509) Veikko Salomaa (62543) Xiuqing Guo (73591) Susan R. Heckbert (7634165) Henry J. Lin (6894089) Jerome I. Rotter (7634114) Kent D. Taylor (7743188) Jie Yao (1440151) Renée de Mutsert (561980) Arie C. Maan (7473804) Dennis O. Mook-Kanamori (148319) Raymond Noordam (333224) Francesco Cucca (145742) Jun Ding (80820) Edward G. Lakatta (6849425) Yong Qian (2377) Kirill V. Tarasov (6849404) Daniel Levy (51573) Honghuang Lin (560598) Christopher H. Newton-Cheh (19694512) Kathryn L. Lunetta (8377740) Alison D. Murray (7743173) David J. Porteous (107720) Blair H. Smith (7726100) Bruno H. Stricker (7464293) André Uitterlinden (150139) Marten E. van den Berg (3921611) Jeffrey Haessler (169224) Rebecca D. Jackson (7802564) Charles Kooperberg (18693) Ulrike Peters (101963) Alexander P. Reiner (8174154) Eric A. Whitsel (7370528) Alvaro Alonso (211735) Dan E. Arking (7588586) Eric Boerwinkle (36288) Georg B. Ehret (19694515) Elsayed Z. Soliman (7743179) Christy L. Avery (8207355) Stephanie M. Gogarten (11068024) Kathleen F. Kerr (9396380) Cathy C. Laurie (7634123) Amanda A. Seyerle (5574107) Adrienne Stilp (15178383) Solmaz Assa (739012) M. Abdullah Said (19694518) M. Yldau van der Ende (19694521) Pier D. Lambiase (10163594) Michele Orini (3097818) Julia Ramirez (2614513) Stefan Van Duijvenboden (5520155) David O. Arnar (19694524) Daniel F. Gudbjartsson (14905953) Hilma Holm (181947) Patrick Sulem (57401) Gudmar Thorleifsson (156887) Rosa B. Thorolfsdottir (19694527) Unnur Thorsteinsdottir (49155) Emelia J. Benjamin (7245926) Andrew Tinker (477693) Kari Stefansson (26484) Patrick T. Ellinor (7743158) Yalda Jamshidi (262159) Steven A. Lubitz (7743194) Patricia B. Munroe (7588601)
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
author_facet	Ioanna Ntalla (174685) Lu-Chen Weng (211804) James H. Cartwright (19694482) Amelia Weber Hall (14930517) Gardar Sveinbjornsson (3820882) Nathan R. Tucker (19694485) Seung Hoan Choi (8174103) Mark D. Chaffin (19694488) Carolina Roselli (3097968) Michael R. Barnes (13158387) Borbala Mifsud (3907267) Helen R. Warren (5410760) Caroline Hayward (149856) Jonathan Marten (3819643) James J. Cranley (19694491) Maria Pina Concas (12643515) Paolo Gasparini (139832) Thibaud Boutin (3819655) Ivana Kolcic (3212697) Ozren Polasek (3965693) Igor Rudan (150101) Nathalia M. Araujo (19694494) Maria Fernanda Lima-Costa (7232726) Antonio Luiz P. Ribeiro (4033124) Renan P. Souza (7955432) Eduardo Tarazona-Santos (145092) Vilmantas Giedraitis (459517) Erik Ingelsson (232651) Anubha Mahajan (206768) Andrew P. Morris (6733298) Fabiola Del Greco M (7635680) Luisa Foco (43249) Martin Gögele (76513) Andrew A. Hicks (7692995) James P. Cook (7643396) Lars Lind (88400) Cecilia M. Lindgren (7541750) Johan Sundström (232655) Christopher P. Nelson (7625975) Muhammad B. Riaz (19694497) Nilesh J. Samani (7579793) Gianfranco Sinagra (290352) Sheila Ulivi (149860) Mika Kähönen (131499) Pashupati P. Mishra (6642206) Nina Mononen (186361) Kjell Nikus (819433) Mark J. Caulfield (7588472) Anna Dominiczak (262121) Sandosh Padmanabhan (238533) May E. Montasser (12109907) Jeff R. O’Connell (19694500) Kathleen Ryan (2930367) Alan R. Shuldiner (12258643) Stefanie Aeschbacher (3164868) David Conen (191914) Lorenz Risch (430248) Sébastien Thériault (11965445) Nina Hutri-Kähönen (186365) Terho Lehtimäki (49739) Leo-Pekka Lyytikäinen (144253) Olli T. Raitakari (7588757) Catriona L. K. Barnes (17094837) Harry Campbell (30339) Peter K. Joshi (7693739) James F. Wilson (7638917) Aaron Isaacs (174648) Jan A. Kors (7464284) Cornelia M. van Duijn (7692962) Paul L. Huang (7743164) Vilmundur Gudnason (8873) Tamara B. Harris (7240184) Lenore J. Launer (7305602) Albert V. Smith (7634078) Erwin P. Bottinger (3212694) Ruth J. F. Loos (6733301) Girish N. Nadkarni (3044592) Michael H. Preuss (15222119) Adolfo Correa (610800) Hao Mei (73778) James Wilson (302768) Thomas Meitinger (26605) Martina Müller-Nurasyid (193464) Annette Peters (62601) Melanie Waldenberger (236985) Massimo Mangino (87550) Timothy D. Spector (7634159) Michiel Rienstra (3342875) Yordi J. van de Vegte (19694503) Pim van der Harst (65060) Niek Verweij (128858) Stefan Kääb (244969) Katharina Schramm (528479) Moritz F. Sinner (7743176) Konstantin Strauch (73658) Michael J. Cutler (11604855) Diane Fatkin (185703) Barry London (7391456) Morten Olesen (10151895) Dan M. Roden (6830087) M. Benjamin Shoemaker (19694506) J. Gustav Smith (162179) Mary L. Biggs (11068021) Joshua C. Bis (7692986) Jennifer A. Brody (7743146) Bruce M. Psaty (7634144) Kenneth Rice (211836) Nona Sotoodehnia (143373) Alessandro De Grandi (76509) Christian Fuchsberger (76512) Cristian Pattaro (65825) Peter P. Pramstaller (7656497) Ian Ford (30666) J. Wouter Jukema (127361) Peter W. Macfarlane (7473807) Stella Trompet (174901) Marcus Dörr (112711) Stephan B. Felix (112722) Uwe Völker (112748) Stefan Weiss (1474864) Aki S. Havulinna (7517390) Antti Jula (37961) Katri Sääksjärvi (19694509) Veikko Salomaa (62543) Xiuqing Guo (73591) Susan R. Heckbert (7634165) Henry J. Lin (6894089) Jerome I. Rotter (7634114) Kent D. Taylor (7743188) Jie Yao (1440151) Renée de Mutsert (561980) Arie C. Maan (7473804) Dennis O. Mook-Kanamori (148319) Raymond Noordam (333224) Francesco Cucca (145742) Jun Ding (80820) Edward G. Lakatta (6849425) Yong Qian (2377) Kirill V. Tarasov (6849404) Daniel Levy (51573) Honghuang Lin (560598) Christopher H. Newton-Cheh (19694512) Kathryn L. Lunetta (8377740) Alison D. Murray (7743173) David J. Porteous (107720) Blair H. Smith (7726100) Bruno H. Stricker (7464293) André Uitterlinden (150139) Marten E. van den Berg (3921611) Jeffrey Haessler (169224) Rebecca D. Jackson (7802564) Charles Kooperberg (18693) Ulrike Peters (101963) Alexander P. Reiner (8174154) Eric A. Whitsel (7370528) Alvaro Alonso (211735) Dan E. Arking (7588586) Eric Boerwinkle (36288) Georg B. Ehret (19694515) Elsayed Z. Soliman (7743179) Christy L. Avery (8207355) Stephanie M. Gogarten (11068024) Kathleen F. Kerr (9396380) Cathy C. Laurie (7634123) Amanda A. Seyerle (5574107) Adrienne Stilp (15178383) Solmaz Assa (739012) M. Abdullah Said (19694518) M. Yldau van der Ende (19694521) Pier D. Lambiase (10163594) Michele Orini (3097818) Julia Ramirez (2614513) Stefan Van Duijvenboden (5520155) David O. Arnar (19694524) Daniel F. Gudbjartsson (14905953) Hilma Holm (181947) Patrick Sulem (57401) Gudmar Thorleifsson (156887) Rosa B. Thorolfsdottir (19694527) Unnur Thorsteinsdottir (49155) Emelia J. Benjamin (7245926) Andrew Tinker (477693) Kari Stefansson (26484) Patrick T. Ellinor (7743158) Yalda Jamshidi (262159) Steven A. Lubitz (7743194) Patricia B. Munroe (7588601)
author_role	author
dc.creator.none.fl_str_mv	Ioanna Ntalla (174685) Lu-Chen Weng (211804) James H. Cartwright (19694482) Amelia Weber Hall (14930517) Gardar Sveinbjornsson (3820882) Nathan R. Tucker (19694485) Seung Hoan Choi (8174103) Mark D. Chaffin (19694488) Carolina Roselli (3097968) Michael R. Barnes (13158387) Borbala Mifsud (3907267) Helen R. Warren (5410760) Caroline Hayward (149856) Jonathan Marten (3819643) James J. Cranley (19694491) Maria Pina Concas (12643515) Paolo Gasparini (139832) Thibaud Boutin (3819655) Ivana Kolcic (3212697) Ozren Polasek (3965693) Igor Rudan (150101) Nathalia M. Araujo (19694494) Maria Fernanda Lima-Costa (7232726) Antonio Luiz P. Ribeiro (4033124) Renan P. Souza (7955432) Eduardo Tarazona-Santos (145092) Vilmantas Giedraitis (459517) Erik Ingelsson (232651) Anubha Mahajan (206768) Andrew P. Morris (6733298) Fabiola Del Greco M (7635680) Luisa Foco (43249) Martin Gögele (76513) Andrew A. Hicks (7692995) James P. Cook (7643396) Lars Lind (88400) Cecilia M. Lindgren (7541750) Johan Sundström (232655) Christopher P. Nelson (7625975) Muhammad B. Riaz (19694497) Nilesh J. Samani (7579793) Gianfranco Sinagra (290352) Sheila Ulivi (149860) Mika Kähönen (131499) Pashupati P. Mishra (6642206) Nina Mononen (186361) Kjell Nikus (819433) Mark J. Caulfield (7588472) Anna Dominiczak (262121) Sandosh Padmanabhan (238533) May E. Montasser (12109907) Jeff R. O’Connell (19694500) Kathleen Ryan (2930367) Alan R. Shuldiner (12258643) Stefanie Aeschbacher (3164868) David Conen (191914) Lorenz Risch (430248) Sébastien Thériault (11965445) Nina Hutri-Kähönen (186365) Terho Lehtimäki (49739) Leo-Pekka Lyytikäinen (144253) Olli T. Raitakari (7588757) Catriona L. K. Barnes (17094837) Harry Campbell (30339) Peter K. Joshi (7693739) James F. Wilson (7638917) Aaron Isaacs (174648) Jan A. Kors (7464284) Cornelia M. van Duijn (7692962) Paul L. Huang (7743164) Vilmundur Gudnason (8873) Tamara B. Harris (7240184) Lenore J. Launer (7305602) Albert V. Smith (7634078) Erwin P. Bottinger (3212694) Ruth J. F. Loos (6733301) Girish N. Nadkarni (3044592) Michael H. Preuss (15222119) Adolfo Correa (610800) Hao Mei (73778) James Wilson (302768) Thomas Meitinger (26605) Martina Müller-Nurasyid (193464) Annette Peters (62601) Melanie Waldenberger (236985) Massimo Mangino (87550) Timothy D. Spector (7634159) Michiel Rienstra (3342875) Yordi J. van de Vegte (19694503) Pim van der Harst (65060) Niek Verweij (128858) Stefan Kääb (244969) Katharina Schramm (528479) Moritz F. Sinner (7743176) Konstantin Strauch (73658) Michael J. Cutler (11604855) Diane Fatkin (185703) Barry London (7391456) Morten Olesen (10151895) Dan M. Roden (6830087) M. Benjamin Shoemaker (19694506) J. Gustav Smith (162179) Mary L. Biggs (11068021) Joshua C. Bis (7692986) Jennifer A. Brody (7743146) Bruce M. Psaty (7634144) Kenneth Rice (211836) Nona Sotoodehnia (143373) Alessandro De Grandi (76509) Christian Fuchsberger (76512) Cristian Pattaro (65825) Peter P. Pramstaller (7656497) Ian Ford (30666) J. Wouter Jukema (127361) Peter W. Macfarlane (7473807) Stella Trompet (174901) Marcus Dörr (112711) Stephan B. Felix (112722) Uwe Völker (112748) Stefan Weiss (1474864) Aki S. Havulinna (7517390) Antti Jula (37961) Katri Sääksjärvi (19694509) Veikko Salomaa (62543) Xiuqing Guo (73591) Susan R. Heckbert (7634165) Henry J. Lin (6894089) Jerome I. Rotter (7634114) Kent D. Taylor (7743188) Jie Yao (1440151) Renée de Mutsert (561980) Arie C. Maan (7473804) Dennis O. Mook-Kanamori (148319) Raymond Noordam (333224) Francesco Cucca (145742) Jun Ding (80820) Edward G. Lakatta (6849425) Yong Qian (2377) Kirill V. Tarasov (6849404) Daniel Levy (51573) Honghuang Lin (560598) Christopher H. Newton-Cheh (19694512) Kathryn L. Lunetta (8377740) Alison D. Murray (7743173) David J. Porteous (107720) Blair H. Smith (7726100) Bruno H. Stricker (7464293) André Uitterlinden (150139) Marten E. van den Berg (3921611) Jeffrey Haessler (169224) Rebecca D. Jackson (7802564) Charles Kooperberg (18693) Ulrike Peters (101963) Alexander P. Reiner (8174154) Eric A. Whitsel (7370528) Alvaro Alonso (211735) Dan E. Arking (7588586) Eric Boerwinkle (36288) Georg B. Ehret (19694515) Elsayed Z. Soliman (7743179) Christy L. Avery (8207355) Stephanie M. Gogarten (11068024) Kathleen F. Kerr (9396380) Cathy C. Laurie (7634123) Amanda A. Seyerle (5574107) Adrienne Stilp (15178383) Solmaz Assa (739012) M. Abdullah Said (19694518) M. Yldau van der Ende (19694521) Pier D. Lambiase (10163594) Michele Orini (3097818) Julia Ramirez (2614513) Stefan Van Duijvenboden (5520155) David O. Arnar (19694524) Daniel F. Gudbjartsson (14905953) Hilma Holm (181947) Patrick Sulem (57401) Gudmar Thorleifsson (156887) Rosa B. Thorolfsdottir (19694527) Unnur Thorsteinsdottir (49155) Emelia J. Benjamin (7245926) Andrew Tinker (477693) Kari Stefansson (26484) Patrick T. Ellinor (7743158) Yalda Jamshidi (262159) Steven A. Lubitz (7743194) Patricia B. Munroe (7588601)
dc.date.none.fl_str_mv	2020-05-21T03:00:00Z
dc.identifier.none.fl_str_mv	10.1038/s41467-020-15706-x
dc.relation.none.fl_str_mv	https://figshare.com/articles/journal_contribution/Multi-ancestry_GWAS_of_the_electrocardiographic_PR_interval_identifies_202_loci_underlying_cardiac_conduction/27051616
dc.rights.none.fl_str_mv	CC BY 4.0 info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv	Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Electrocardiogram (ECG) PR interval Atrioventricular conduction Genome-wide association study (GWAS) Polygenic risk Cardiovascular disease Atrial fibrillation (AF) Heart block Cardiac muscle development Multi-ancestry Polygenic predisposition UK Biobank Cardiovascular genetics
dc.title.none.fl_str_mv	Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
dc.type.none.fl_str_mv	Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal
description	<p dir="ltr">The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease.</p><h2>Other Information</h2><p dir="ltr">Published in: Nature Communications<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41467-020-15706-x" target="_blank">https://dx.doi.org/10.1038/s41467-020-15706-x</a></p>
eu_rights_str_mv	openAccess
id	Manara2_d3e6ab992ba188477f7b4600f7100432
identifier_str_mv	10.1038/s41467-020-15706-x
network_acronym_str	Manara2
network_name_str	Manara2
oai_identifier_str	oai:figshare.com:article/27051616
publishDate	2020
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv	CC BY 4.0
spelling	Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conductionIoanna Ntalla (174685)Lu-Chen Weng (211804)James H. Cartwright (19694482)Amelia Weber Hall (14930517)Gardar Sveinbjornsson (3820882)Nathan R. Tucker (19694485)Seung Hoan Choi (8174103)Mark D. Chaffin (19694488)Carolina Roselli (3097968)Michael R. Barnes (13158387)Borbala Mifsud (3907267)Helen R. Warren (5410760)Caroline Hayward (149856)Jonathan Marten (3819643)James J. Cranley (19694491)Maria Pina Concas (12643515)Paolo Gasparini (139832)Thibaud Boutin (3819655)Ivana Kolcic (3212697)Ozren Polasek (3965693)Igor Rudan (150101)Nathalia M. Araujo (19694494)Maria Fernanda Lima-Costa (7232726)Antonio Luiz P. Ribeiro (4033124)Renan P. Souza (7955432)Eduardo Tarazona-Santos (145092)Vilmantas Giedraitis (459517)Erik Ingelsson (232651)Anubha Mahajan (206768)Andrew P. Morris (6733298)Fabiola Del Greco M (7635680)Luisa Foco (43249)Martin Gögele (76513)Andrew A. Hicks (7692995)James P. Cook (7643396)Lars Lind (88400)Cecilia M. Lindgren (7541750)Johan Sundström (232655)Christopher P. Nelson (7625975)Muhammad B. Riaz (19694497)Nilesh J. Samani (7579793)Gianfranco Sinagra (290352)Sheila Ulivi (149860)Mika Kähönen (131499)Pashupati P. Mishra (6642206)Nina Mononen (186361)Kjell Nikus (819433)Mark J. Caulfield (7588472)Anna Dominiczak (262121)Sandosh Padmanabhan (238533)May E. Montasser (12109907)Jeff R. O’Connell (19694500)Kathleen Ryan (2930367)Alan R. Shuldiner (12258643)Stefanie Aeschbacher (3164868)David Conen (191914)Lorenz Risch (430248)Sébastien Thériault (11965445)Nina Hutri-Kähönen (186365)Terho Lehtimäki (49739)Leo-Pekka Lyytikäinen (144253)Olli T. Raitakari (7588757)Catriona L. K. Barnes (17094837)Harry Campbell (30339)Peter K. Joshi (7693739)James F. Wilson (7638917)Aaron Isaacs (174648)Jan A. Kors (7464284)Cornelia M. van Duijn (7692962)Paul L. Huang (7743164)Vilmundur Gudnason (8873)Tamara B. Harris (7240184)Lenore J. Launer (7305602)Albert V. Smith (7634078)Erwin P. Bottinger (3212694)Ruth J. F. Loos (6733301)Girish N. Nadkarni (3044592)Michael H. Preuss (15222119)Adolfo Correa (610800)Hao Mei (73778)James Wilson (302768)Thomas Meitinger (26605)Martina Müller-Nurasyid (193464)Annette Peters (62601)Melanie Waldenberger (236985)Massimo Mangino (87550)Timothy D. Spector (7634159)Michiel Rienstra (3342875)Yordi J. van de Vegte (19694503)Pim van der Harst (65060)Niek Verweij (128858)Stefan Kääb (244969)Katharina Schramm (528479)Moritz F. Sinner (7743176)Konstantin Strauch (73658)Michael J. Cutler (11604855)Diane Fatkin (185703)Barry London (7391456)Morten Olesen (10151895)Dan M. Roden (6830087)M. Benjamin Shoemaker (19694506)J. Gustav Smith (162179)Mary L. Biggs (11068021)Joshua C. Bis (7692986)Jennifer A. Brody (7743146)Bruce M. Psaty (7634144)Kenneth Rice (211836)Nona Sotoodehnia (143373)Alessandro De Grandi (76509)Christian Fuchsberger (76512)Cristian Pattaro (65825)Peter P. Pramstaller (7656497)Ian Ford (30666)J. Wouter Jukema (127361)Peter W. Macfarlane (7473807)Stella Trompet (174901)Marcus Dörr (112711)Stephan B. Felix (112722)Uwe Völker (112748)Stefan Weiss (1474864)Aki S. Havulinna (7517390)Antti Jula (37961)Katri Sääksjärvi (19694509)Veikko Salomaa (62543)Xiuqing Guo (73591)Susan R. Heckbert (7634165)Henry J. Lin (6894089)Jerome I. Rotter (7634114)Kent D. Taylor (7743188)Jie Yao (1440151)Renée de Mutsert (561980)Arie C. Maan (7473804)Dennis O. Mook-Kanamori (148319)Raymond Noordam (333224)Francesco Cucca (145742)Jun Ding (80820)Edward G. Lakatta (6849425)Yong Qian (2377)Kirill V. Tarasov (6849404)Daniel Levy (51573)Honghuang Lin (560598)Christopher H. Newton-Cheh (19694512)Kathryn L. Lunetta (8377740)Alison D. Murray (7743173)David J. Porteous (107720)Blair H. Smith (7726100)Bruno H. Stricker (7464293)André Uitterlinden (150139)Marten E. van den Berg (3921611)Jeffrey Haessler (169224)Rebecca D. Jackson (7802564)Charles Kooperberg (18693)Ulrike Peters (101963)Alexander P. Reiner (8174154)Eric A. Whitsel (7370528)Alvaro Alonso (211735)Dan E. Arking (7588586)Eric Boerwinkle (36288)Georg B. Ehret (19694515)Elsayed Z. Soliman (7743179)Christy L. Avery (8207355)Stephanie M. Gogarten (11068024)Kathleen F. Kerr (9396380)Cathy C. Laurie (7634123)Amanda A. Seyerle (5574107)Adrienne Stilp (15178383)Solmaz Assa (739012)M. Abdullah Said (19694518)M. Yldau van der Ende (19694521)Pier D. Lambiase (10163594)Michele Orini (3097818)Julia Ramirez (2614513)Stefan Van Duijvenboden (5520155)David O. Arnar (19694524)Daniel F. Gudbjartsson (14905953)Hilma Holm (181947)Patrick Sulem (57401)Gudmar Thorleifsson (156887)Rosa B. Thorolfsdottir (19694527)Unnur Thorsteinsdottir (49155)Emelia J. Benjamin (7245926)Andrew Tinker (477693)Kari Stefansson (26484)Patrick T. Ellinor (7743158)Yalda Jamshidi (262159)Steven A. Lubitz (7743194)Patricia B. Munroe (7588601)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesElectrocardiogram (ECG)PR intervalAtrioventricular conductionGenome-wide association study (GWAS)Polygenic riskCardiovascular diseaseAtrial fibrillation (AF)Heart blockCardiac muscle developmentMulti-ancestryPolygenic predispositionUK BiobankCardiovascular genetics<p dir="ltr">The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease.</p><h2>Other Information</h2><p dir="ltr">Published in: Nature Communications<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41467-020-15706-x" target="_blank">https://dx.doi.org/10.1038/s41467-020-15706-x</a></p>2020-05-21T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41467-020-15706-xhttps://figshare.com/articles/journal_contribution/Multi-ancestry_GWAS_of_the_electrocardiographic_PR_interval_identifies_202_loci_underlying_cardiac_conduction/27051616CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/270516162020-05-21T03:00:00Z
spellingShingle	Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction Ioanna Ntalla (174685) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Electrocardiogram (ECG) PR interval Atrioventricular conduction Genome-wide association study (GWAS) Polygenic risk Cardiovascular disease Atrial fibrillation (AF) Heart block Cardiac muscle development Multi-ancestry Polygenic predisposition UK Biobank Cardiovascular genetics
status_str	publishedVersion
title	Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
title_full	Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
title_fullStr	Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
title_full_unstemmed	Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
title_short	Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
title_sort	Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
topic	Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Electrocardiogram (ECG) PR interval Atrioventricular conduction Genome-wide association study (GWAS) Polygenic risk Cardiovascular disease Atrial fibrillation (AF) Heart block Cardiac muscle development Multi-ancestry Polygenic predisposition UK Biobank Cardiovascular genetics

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

مواد مشابهة