Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer
<p dir="ltr">Circular RNAs (circRNAs) are regulatory elements that are involved in orchestrating gene expression and protein functions and are implicated in various biological processes including cancer. Notably, breast cancer has a significant mortality rate and is one of the most c...
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2023
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| _version_ | 1864513521137483776 |
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| author | Mohanraj Gopikrishnan (17773449) |
| author2 | Hephzibah Cathryn R (17773452) Gnanasambandan R (17773455) Hossam M. Ashour (9555847) Gianfranco Pintus (91638) Mohamed Hammad (10431225) Manoj Kumar Kashyap (1912381) George Priya Doss C (8653101) Hatem Zayed (835448) |
| author2_role | author author author author author author author author |
| author_facet | Mohanraj Gopikrishnan (17773449) Hephzibah Cathryn R (17773452) Gnanasambandan R (17773455) Hossam M. Ashour (9555847) Gianfranco Pintus (91638) Mohamed Hammad (10431225) Manoj Kumar Kashyap (1912381) George Priya Doss C (8653101) Hatem Zayed (835448) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mohanraj Gopikrishnan (17773449) Hephzibah Cathryn R (17773452) Gnanasambandan R (17773455) Hossam M. Ashour (9555847) Gianfranco Pintus (91638) Mohamed Hammad (10431225) Manoj Kumar Kashyap (1912381) George Priya Doss C (8653101) Hatem Zayed (835448) |
| dc.date.none.fl_str_mv | 2023-05-27T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s10142-023-01083-3 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Therapeutic_and_diagnostic_applications_of_exosomal_circRNAs_in_breast_cancer/24981180 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Breast cancer circRNA miRNA sponges circRNA biomarkers Exosomal circRNAs Tumor-suppressive circRNAs |
| dc.title.none.fl_str_mv | Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Circular RNAs (circRNAs) are regulatory elements that are involved in orchestrating gene expression and protein functions and are implicated in various biological processes including cancer. Notably, breast cancer has a significant mortality rate and is one of the most common malignancies in women. CircRNAs have been demonstrated to contribute to the pathogenesis of breast cancer including its initiation, progression, metastasis, and resistance to drugs. By acting as miRNA sponges, circRNAs can indirectly influence gene expression by disrupting miRNA regulation of their target genes, ultimately altering the course of cancer development and progression. Additionally, circRNAs can interact with proteins and modulate their functions including signaling pathways involved in the initiation and development of cancer. Recently, circRNAs can encode peptides that play a role in the pathophysiology of breast cancer and other diseases and their potential as diagnostic biomarkers and therapeutic targets for various cancers including breast cancer. CircRNAs possess biomarkers that differentiate, such as stability, specificity, and sensitivity, and can be detected in several biological specimens such as blood, saliva, and urine. Moreover, circRNAs play an important role in various cellular processes including cell proliferation, differentiation, and apoptosis, all of which are integral factors in the development and progression of cancer. This review synthesizes the functions of circRNAs in breast cancer, scrutinizing their contributions to the onset and evolution of the disease through their interactions with exosomes and cancer-related intracellular pathways. It also delves into the potential use of circRNA as a biomarker and therapeutic target against breast cancer. It discusses various databases and online tools that offer crucial circRNA information and regulatory networks. Lastly, the challenges and prospects of utilizing circRNAs in clinical settings associated with breast cancer are explored.</p><h2>Other Information</h2><p dir="ltr">Published in: Functional & Integrative Genomics<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s10142-023-01083-3" target="_blank">https://dx.doi.org/10.1007/s10142-023-01083-3</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d3fcfcd85f0b34af0013be1fcab3be81 |
| identifier_str_mv | 10.1007/s10142-023-01083-3 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24981180 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Therapeutic and diagnostic applications of exosomal circRNAs in breast cancerMohanraj Gopikrishnan (17773449)Hephzibah Cathryn R (17773452)Gnanasambandan R (17773455)Hossam M. Ashour (9555847)Gianfranco Pintus (91638)Mohamed Hammad (10431225)Manoj Kumar Kashyap (1912381)George Priya Doss C (8653101)Hatem Zayed (835448)Biological sciencesGeneticsBiomedical and clinical sciencesOncology and carcinogenesisBreast cancercircRNAmiRNA spongescircRNA biomarkersExosomal circRNAsTumor-suppressive circRNAs<p dir="ltr">Circular RNAs (circRNAs) are regulatory elements that are involved in orchestrating gene expression and protein functions and are implicated in various biological processes including cancer. Notably, breast cancer has a significant mortality rate and is one of the most common malignancies in women. CircRNAs have been demonstrated to contribute to the pathogenesis of breast cancer including its initiation, progression, metastasis, and resistance to drugs. By acting as miRNA sponges, circRNAs can indirectly influence gene expression by disrupting miRNA regulation of their target genes, ultimately altering the course of cancer development and progression. Additionally, circRNAs can interact with proteins and modulate their functions including signaling pathways involved in the initiation and development of cancer. Recently, circRNAs can encode peptides that play a role in the pathophysiology of breast cancer and other diseases and their potential as diagnostic biomarkers and therapeutic targets for various cancers including breast cancer. CircRNAs possess biomarkers that differentiate, such as stability, specificity, and sensitivity, and can be detected in several biological specimens such as blood, saliva, and urine. Moreover, circRNAs play an important role in various cellular processes including cell proliferation, differentiation, and apoptosis, all of which are integral factors in the development and progression of cancer. This review synthesizes the functions of circRNAs in breast cancer, scrutinizing their contributions to the onset and evolution of the disease through their interactions with exosomes and cancer-related intracellular pathways. It also delves into the potential use of circRNA as a biomarker and therapeutic target against breast cancer. It discusses various databases and online tools that offer crucial circRNA information and regulatory networks. Lastly, the challenges and prospects of utilizing circRNAs in clinical settings associated with breast cancer are explored.</p><h2>Other Information</h2><p dir="ltr">Published in: Functional & Integrative Genomics<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s10142-023-01083-3" target="_blank">https://dx.doi.org/10.1007/s10142-023-01083-3</a></p>2023-05-27T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s10142-023-01083-3https://figshare.com/articles/journal_contribution/Therapeutic_and_diagnostic_applications_of_exosomal_circRNAs_in_breast_cancer/24981180CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/249811802023-05-27T03:00:00Z |
| spellingShingle | Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer Mohanraj Gopikrishnan (17773449) Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Breast cancer circRNA miRNA sponges circRNA biomarkers Exosomal circRNAs Tumor-suppressive circRNAs |
| status_str | publishedVersion |
| title | Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer |
| title_full | Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer |
| title_fullStr | Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer |
| title_full_unstemmed | Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer |
| title_short | Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer |
| title_sort | Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer |
| topic | Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Breast cancer circRNA miRNA sponges circRNA biomarkers Exosomal circRNAs Tumor-suppressive circRNAs |