Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes
<p dir="ltr">Type 1 diabetes (T1D) is an autoimmune condition where the body’s immune cells destroy their insulin-producing pancreatic beta cells leading to dysregulated glycaemia. Individuals with T1D control their blood glucose through exogenous insulin replacement therapy, often u...
محفوظ في:
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2020
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513511840808960 |
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| author | Ammira-Sarah AL-Shabeeb Akil (18949477) |
| author2 | Laila F. Jerman (18949480) Esraa Yassin (11618606) Sujitha S. Padmajeya (14152698) Alya Al-Kurbi (18543970) Khalid A. Fakhro (3158862) |
| author2_role | author author author author author |
| author_facet | Ammira-Sarah AL-Shabeeb Akil (18949477) Laila F. Jerman (18949480) Esraa Yassin (11618606) Sujitha S. Padmajeya (14152698) Alya Al-Kurbi (18543970) Khalid A. Fakhro (3158862) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ammira-Sarah AL-Shabeeb Akil (18949477) Laila F. Jerman (18949480) Esraa Yassin (11618606) Sujitha S. Padmajeya (14152698) Alya Al-Kurbi (18543970) Khalid A. Fakhro (3158862) |
| dc.date.none.fl_str_mv | 2020-11-03T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cells9112403 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Reading_between_the_Genetic_Lines_How_Epigenetics_is_Unlocking_Novel_Therapies_for_Type_1_Diabetes/26144119 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics chromatin DNA methylation epigenetics histone modifications metaboloepigenetics miRNA therapy type 1 diabetes |
| dc.title.none.fl_str_mv | Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Type 1 diabetes (T1D) is an autoimmune condition where the body’s immune cells destroy their insulin-producing pancreatic beta cells leading to dysregulated glycaemia. Individuals with T1D control their blood glucose through exogenous insulin replacement therapy, often using multiple daily injections or pumps. However, failure to accurately mimic intrinsic glucose regulation results in glucose fluctuations and long-term complications impacting key organs such as the heart, kidneys, and/or the eyes. It is well established that genetic and environmental factors contribute to the initiation and progression of T1D, but recent studies show that epigenetic modifications are also important. Here, we discuss key epigenetic modifications associated with T1D pathogenesis and discuss how recent research is finding ways to harness epigenetic mechanisms to prevent, reverse, or manage T1D.</p><h2>Other Information</h2><p dir="ltr">Published in: Cells<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cells9112403" target="_blank">https://dx.doi.org/10.3390/cells9112403</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d4297acfa4a9d51d5f124ae79a92b23d |
| identifier_str_mv | 10.3390/cells9112403 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26144119 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 DiabetesAmmira-Sarah AL-Shabeeb Akil (18949477)Laila F. Jerman (18949480)Esraa Yassin (11618606)Sujitha S. Padmajeya (14152698)Alya Al-Kurbi (18543970)Khalid A. Fakhro (3158862)Biological sciencesGeneticsBiomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicschromatinDNA methylationepigeneticshistone modificationsmetaboloepigeneticsmiRNAtherapytype 1 diabetes<p dir="ltr">Type 1 diabetes (T1D) is an autoimmune condition where the body’s immune cells destroy their insulin-producing pancreatic beta cells leading to dysregulated glycaemia. Individuals with T1D control their blood glucose through exogenous insulin replacement therapy, often using multiple daily injections or pumps. However, failure to accurately mimic intrinsic glucose regulation results in glucose fluctuations and long-term complications impacting key organs such as the heart, kidneys, and/or the eyes. It is well established that genetic and environmental factors contribute to the initiation and progression of T1D, but recent studies show that epigenetic modifications are also important. Here, we discuss key epigenetic modifications associated with T1D pathogenesis and discuss how recent research is finding ways to harness epigenetic mechanisms to prevent, reverse, or manage T1D.</p><h2>Other Information</h2><p dir="ltr">Published in: Cells<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cells9112403" target="_blank">https://dx.doi.org/10.3390/cells9112403</a></p>2020-11-03T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cells9112403https://figshare.com/articles/journal_contribution/Reading_between_the_Genetic_Lines_How_Epigenetics_is_Unlocking_Novel_Therapies_for_Type_1_Diabetes/26144119CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/261441192020-11-03T03:00:00Z |
| spellingShingle | Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes Ammira-Sarah AL-Shabeeb Akil (18949477) Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics chromatin DNA methylation epigenetics histone modifications metaboloepigenetics miRNA therapy type 1 diabetes |
| status_str | publishedVersion |
| title | Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes |
| title_full | Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes |
| title_fullStr | Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes |
| title_full_unstemmed | Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes |
| title_short | Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes |
| title_sort | Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes |
| topic | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics chromatin DNA methylation epigenetics histone modifications metaboloepigenetics miRNA therapy type 1 diabetes |