Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training
<h2>Background</h2> <p>Polycystic ovary syndrome (PCOS) is associated with obesity, diabetes, and insulin resistance. The circulating C1Q/TNF-related proteins (CTRP-2, CTRP-9) and growth differentiation factors (GDF-8, GDF-15) contribute to glucose and lipid homeostasis. The effect...
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| مؤلفون آخرون: | , , , , , , , , , |
| منشور في: |
2022
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| _version_ | 1864513566590107648 |
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| author | Jayakumar Jerobin (6595520) |
| author2 | Manjunath Ramanjaneya (519259) Ilham Bettahi (363910) Raihanath Parammal (11908995) Kodappully Sivaraman Siveen (9440771) Meis Alkasem (9440768) Myint Aye (4969396) Thozhukat Sathyapalan (704787) Monica Skarulis (9440774) Stephen L. Atkin (6684368) Abdul Badi Abou-Samra (9417977) |
| author2_role | author author author author author author author author author author |
| author_facet | Jayakumar Jerobin (6595520) Manjunath Ramanjaneya (519259) Ilham Bettahi (363910) Raihanath Parammal (11908995) Kodappully Sivaraman Siveen (9440771) Meis Alkasem (9440768) Myint Aye (4969396) Thozhukat Sathyapalan (704787) Monica Skarulis (9440774) Stephen L. Atkin (6684368) Abdul Badi Abou-Samra (9417977) |
| author_role | author |
| dc.creator.none.fl_str_mv | Jayakumar Jerobin (6595520) Manjunath Ramanjaneya (519259) Ilham Bettahi (363910) Raihanath Parammal (11908995) Kodappully Sivaraman Siveen (9440771) Meis Alkasem (9440768) Myint Aye (4969396) Thozhukat Sathyapalan (704787) Monica Skarulis (9440774) Stephen L. Atkin (6684368) Abdul Badi Abou-Samra (9417977) |
| dc.date.none.fl_str_mv | 2022-11-22T21:18:02Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12944-021-01463-3 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Regulation_of_circulating_CTRP-2_CTRP-9_and_GDF-8_GDF-15_by_intralipids_and_insulin_in_healthy_control_and_polycystic_ovary_syndrome_women_following_chronic_exercise_training/21598431 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medical biochemistry and metabolomics Biochemistry (medical) Clinical Biochemistry Endocrinology Endocrinology, Diabetes and Metabolism |
| dc.title.none.fl_str_mv | Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h2>Background</h2> <p>Polycystic ovary syndrome (PCOS) is associated with obesity, diabetes, and insulin resistance. The circulating C1Q/TNF-related proteins (CTRP-2, CTRP-9) and growth differentiation factors (GDF-8, GDF-15) contribute to glucose and lipid homeostasis. The effects of intralipids and insulin infusion on CTRP-2, CTRP-9, GDF-8 and GDF-15 in PCOS and control subjects before and after chronic exercise training were examined.</p> <h2>Methods</h2> <p>Ten PCOS and nine healthy subjects were studied at baseline status and after moderate-intensity chronic exercise training (1 h exercise, 3 times per week, 8 weeks). All participants were infused with 1.5 mL/min of saline or intralipids (20%) for 5 h, and during the last 2 h of saline or intralipids infusion hyperinsulinemic-euglycemic clamp (HIEC) was performed. CTRP-2, CTRP-9, GDF-8 and GDF-15 levels were measured at 0, 3 and 5 h.</p> <h2>Results</h2> <p>Intralipids dramatically increased CTRP-2 levels in PCOS (P = 0.02) and control (P = 0.004) subjects, which was not affected by insulin infusion or by exercise. Intralipids alone had no effects on CTRP-9, GDF-8, or GDF-15. Insulin increased the levels of GDF-15 in control subjects (P = 0.05) during the saline study and in PCOS subjects (P = 0.04) during the intralipid infusion. Insulin suppressed CTRP9 levels during the intralipid study in both PCOS (P = 0.04) and control (P = 0.01) subjects. Exercise significantly reduced fasting GDF-8 levels in PCOS (P = 0.03) and control (P = 0.04) subjects; however, intralipids infusion after chronic exercise training increased GDF-8 levels in both PCOS (P = 0.003) and control (P = 0.05) subjects and insulin infusion during intralipid infusion reduced the rise of GDF-8 levels.</p> <h2>Conclusion</h2> <p>This study showed that exogenous lipids modulate CTRP-2, which might have a physiological role in lipid metabolism. Since chronic exercise training reduced fasting GDF-8 levels; GDF-8 might have a role in humoral adaptation to exercise. GDF-15 and CTRP-9 levels are responsive to insulin, and thus they may play a role in insulin responses.</p><h2>Other Information</h2> <p> Published in: Lipids in Health and Disease<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12944-021-01463-3" target="_blank">http://dx.doi.org/10.1186/s12944-021-01463-3</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d44f60f5019656cea8d19aec79be9a44 |
| identifier_str_mv | 10.1186/s12944-021-01463-3 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598431 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise trainingJayakumar Jerobin (6595520)Manjunath Ramanjaneya (519259)Ilham Bettahi (363910)Raihanath Parammal (11908995)Kodappully Sivaraman Siveen (9440771)Meis Alkasem (9440768)Myint Aye (4969396)Thozhukat Sathyapalan (704787)Monica Skarulis (9440774)Stephen L. Atkin (6684368)Abdul Badi Abou-Samra (9417977)Medical biochemistry and metabolomicsBiochemistry (medical)Clinical BiochemistryEndocrinologyEndocrinology, Diabetes and Metabolism<h2>Background</h2> <p>Polycystic ovary syndrome (PCOS) is associated with obesity, diabetes, and insulin resistance. The circulating C1Q/TNF-related proteins (CTRP-2, CTRP-9) and growth differentiation factors (GDF-8, GDF-15) contribute to glucose and lipid homeostasis. The effects of intralipids and insulin infusion on CTRP-2, CTRP-9, GDF-8 and GDF-15 in PCOS and control subjects before and after chronic exercise training were examined.</p> <h2>Methods</h2> <p>Ten PCOS and nine healthy subjects were studied at baseline status and after moderate-intensity chronic exercise training (1 h exercise, 3 times per week, 8 weeks). All participants were infused with 1.5 mL/min of saline or intralipids (20%) for 5 h, and during the last 2 h of saline or intralipids infusion hyperinsulinemic-euglycemic clamp (HIEC) was performed. CTRP-2, CTRP-9, GDF-8 and GDF-15 levels were measured at 0, 3 and 5 h.</p> <h2>Results</h2> <p>Intralipids dramatically increased CTRP-2 levels in PCOS (P = 0.02) and control (P = 0.004) subjects, which was not affected by insulin infusion or by exercise. Intralipids alone had no effects on CTRP-9, GDF-8, or GDF-15. Insulin increased the levels of GDF-15 in control subjects (P = 0.05) during the saline study and in PCOS subjects (P = 0.04) during the intralipid infusion. Insulin suppressed CTRP9 levels during the intralipid study in both PCOS (P = 0.04) and control (P = 0.01) subjects. Exercise significantly reduced fasting GDF-8 levels in PCOS (P = 0.03) and control (P = 0.04) subjects; however, intralipids infusion after chronic exercise training increased GDF-8 levels in both PCOS (P = 0.003) and control (P = 0.05) subjects and insulin infusion during intralipid infusion reduced the rise of GDF-8 levels.</p> <h2>Conclusion</h2> <p>This study showed that exogenous lipids modulate CTRP-2, which might have a physiological role in lipid metabolism. Since chronic exercise training reduced fasting GDF-8 levels; GDF-8 might have a role in humoral adaptation to exercise. GDF-15 and CTRP-9 levels are responsive to insulin, and thus they may play a role in insulin responses.</p><h2>Other Information</h2> <p> Published in: Lipids in Health and Disease<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12944-021-01463-3" target="_blank">http://dx.doi.org/10.1186/s12944-021-01463-3</a></p>2022-11-22T21:18:02ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12944-021-01463-3https://figshare.com/articles/journal_contribution/Regulation_of_circulating_CTRP-2_CTRP-9_and_GDF-8_GDF-15_by_intralipids_and_insulin_in_healthy_control_and_polycystic_ovary_syndrome_women_following_chronic_exercise_training/21598431CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215984312022-11-22T21:18:02Z |
| spellingShingle | Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training Jayakumar Jerobin (6595520) Medical biochemistry and metabolomics Biochemistry (medical) Clinical Biochemistry Endocrinology Endocrinology, Diabetes and Metabolism |
| status_str | publishedVersion |
| title | Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training |
| title_full | Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training |
| title_fullStr | Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training |
| title_full_unstemmed | Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training |
| title_short | Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training |
| title_sort | Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training |
| topic | Medical biochemistry and metabolomics Biochemistry (medical) Clinical Biochemistry Endocrinology Endocrinology, Diabetes and Metabolism |