Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review
<p dir="ltr">Human papillomaviruses (HPVs) and the Epstein–Barr virus (EBV) are the most common oncoviruses, contributing to approximately 10%–15% of all malignancies. Oncoproteins of high-risk HPVs (E5 and E6/E7), as well as EBV (LMP1, LMP2A and EBNA1), play a principal role in the...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2020
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إضافة وسم
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| _version_ | 1864513564169994240 |
|---|---|
| author | Queenie Fernandes (14557388) |
| author2 | Ishita Gupta (9203073) Semir Vranic (3353012) Ala-Eddin Al Moustafa (14153205) |
| author2_role | author author author |
| author_facet | Queenie Fernandes (14557388) Ishita Gupta (9203073) Semir Vranic (3353012) Ala-Eddin Al Moustafa (14153205) |
| author_role | author |
| dc.creator.none.fl_str_mv | Queenie Fernandes (14557388) Ishita Gupta (9203073) Semir Vranic (3353012) Ala-Eddin Al Moustafa (14153205) |
| dc.date.none.fl_str_mv | 2020-04-20T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/pathogens9040300 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Human_Papillomaviruses_and_Epstein_Barr_Virus_Interactions_in_Colorectal_Cancer_A_Brief_Review/23626368 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Immunology Medical microbiology Oncology and carcinogenesis EBV high-risk HPV oncovirus cooperation colorectal cancer |
| dc.title.none.fl_str_mv | Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Human papillomaviruses (HPVs) and the Epstein–Barr virus (EBV) are the most common oncoviruses, contributing to approximately 10%–15% of all malignancies. Oncoproteins of high-risk HPVs (E5 and E6/E7), as well as EBV (LMP1, LMP2A and EBNA1), play a principal role in the onset and progression of several human carcinomas, including head and neck, cervical and colorectal. Oncoproteins of high-risk HPVs and EBV can cooperate to initiate and/or enhance epithelial-mesenchymal transition (EMT) events, which represents one of the hallmarks of cancer progression and metastasis. Although the role of these oncoviruses in several cancers is well established, their role in the pathogenesis of colorectal cancer is still nascent. This review presents an overview of the most recent advances related to the presence and role of high-risk HPVs and EBV in colorectal cancer, with an emphasis on their cooperation in colorectal carcinogenesis.</p><h2>Other Information</h2><p dir="ltr">Published in: Pathogens<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.3390/pathogens9040300" target="_blank">http://dx.doi.org/10.3390/pathogens9040300</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d527fcede19d6a7b21d0b7e800d7bd07 |
| identifier_str_mv | 10.3390/pathogens9040300 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/23626368 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief ReviewQueenie Fernandes (14557388)Ishita Gupta (9203073)Semir Vranic (3353012)Ala-Eddin Al Moustafa (14153205)Biomedical and clinical sciencesClinical sciencesImmunologyMedical microbiologyOncology and carcinogenesisEBVhigh-risk HPVoncovirus cooperationcolorectal cancer<p dir="ltr">Human papillomaviruses (HPVs) and the Epstein–Barr virus (EBV) are the most common oncoviruses, contributing to approximately 10%–15% of all malignancies. Oncoproteins of high-risk HPVs (E5 and E6/E7), as well as EBV (LMP1, LMP2A and EBNA1), play a principal role in the onset and progression of several human carcinomas, including head and neck, cervical and colorectal. Oncoproteins of high-risk HPVs and EBV can cooperate to initiate and/or enhance epithelial-mesenchymal transition (EMT) events, which represents one of the hallmarks of cancer progression and metastasis. Although the role of these oncoviruses in several cancers is well established, their role in the pathogenesis of colorectal cancer is still nascent. This review presents an overview of the most recent advances related to the presence and role of high-risk HPVs and EBV in colorectal cancer, with an emphasis on their cooperation in colorectal carcinogenesis.</p><h2>Other Information</h2><p dir="ltr">Published in: Pathogens<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.3390/pathogens9040300" target="_blank">http://dx.doi.org/10.3390/pathogens9040300</a></p>2020-04-20T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/pathogens9040300https://figshare.com/articles/journal_contribution/Human_Papillomaviruses_and_Epstein_Barr_Virus_Interactions_in_Colorectal_Cancer_A_Brief_Review/23626368CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/236263682020-04-20T00:00:00Z |
| spellingShingle | Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review Queenie Fernandes (14557388) Biomedical and clinical sciences Clinical sciences Immunology Medical microbiology Oncology and carcinogenesis EBV high-risk HPV oncovirus cooperation colorectal cancer |
| status_str | publishedVersion |
| title | Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review |
| title_full | Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review |
| title_fullStr | Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review |
| title_full_unstemmed | Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review |
| title_short | Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review |
| title_sort | Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review |
| topic | Biomedical and clinical sciences Clinical sciences Immunology Medical microbiology Oncology and carcinogenesis EBV high-risk HPV oncovirus cooperation colorectal cancer |