Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar
<p dir="ltr">The objective of this study is to characterize the seroprevalence of anti-dengue (DENV) and anti-chikungunya (CHIKV) antibodies among blood donors residing in Qatar who are Middle East and North Africa (MENA) nationals and non-nationals. Sera were collected from adult bl...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , , , , |
| Published: |
2019
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513521732026368 |
|---|---|
| author | John M. Humphrey (1601860) |
| author2 | Enas S. Al-Absi (6281936) Munia M. Hamdan (6281939) Sara S. Okasha (6281942) Diyna M. Al-Trmanini (6281945) Hend G. El-Dous (6281948) Soha R. Dargham (3613250) John Schieffelin (3468986) Laith J. Abu-Raddad (9262524) Gheyath K. Nasrallah (9200525) |
| author2_role | author author author author author author author author author |
| author_facet | John M. Humphrey (1601860) Enas S. Al-Absi (6281936) Munia M. Hamdan (6281939) Sara S. Okasha (6281942) Diyna M. Al-Trmanini (6281945) Hend G. El-Dous (6281948) Soha R. Dargham (3613250) John Schieffelin (3468986) Laith J. Abu-Raddad (9262524) Gheyath K. Nasrallah (9200525) |
| author_role | author |
| dc.creator.none.fl_str_mv | John M. Humphrey (1601860) Enas S. Al-Absi (6281936) Munia M. Hamdan (6281939) Sara S. Okasha (6281942) Diyna M. Al-Trmanini (6281945) Hend G. El-Dous (6281948) Soha R. Dargham (3613250) John Schieffelin (3468986) Laith J. Abu-Raddad (9262524) Gheyath K. Nasrallah (9200525) |
| dc.date.none.fl_str_mv | 2019-01-31T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0211574 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Dengue_and_chikungunya_seroprevalence_among_Qatari_nationals_and_immigrants_residing_in_Qatar/25347808 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences anti-dengue (DENV) anti-chikungunya (CHIKV) Qatar antibodies |
| dc.title.none.fl_str_mv | Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The objective of this study is to characterize the seroprevalence of anti-dengue (DENV) and anti-chikungunya (CHIKV) antibodies among blood donors residing in Qatar who are Middle East and North Africa (MENA) nationals and non-nationals. Sera were collected from adult blood donors in Qatar from 2013 to 2016 and tested for anti-DENV and anti-CHIKV IgG using commercial microplate enzyme-linked immunosorbent assays. Age-specific seroprevalence was summarized by region/nationality: Asia (India, Philippines), Middle East (Iran, Jordan, Lebanon, Pakistan, Palestine, Syria, Yemen), North Africa (Egypt, Sudan), Qatar. The adjusted odds of anti-DENV and anti-CHIKV IgG seropositivity was estimated by logistic regression. Among 1,992 serum samples tested, Asian nationals had higher adjusted odds of being seropositive for anti-DENV antibodies compared to nationals of the Middle East (aOR 0.05, 95% CI 0.04–0.07), North Africa (aOR 0.14, 95% CI 0.10–0.20), and Qatar (aOR 0.01, 95% CI 0.01–0.03). Asian nationals also had higher adjusted odds of being seropositive for anti-CHIKV antibodies compared to those from the Middle East (aOR 0.14, 95% CI 0.07–0.27), North Africa (aOR 0.50, 95% CI 0.26–0.96), and Qatar (aOR 0.38, 95% CI 0.15–0.96). The adjusted odds of being anti-DENV seropositive was higher among antiCHIKV seropositive adults, and vice versa (aOR 1.94, 95% CI 1.09–3.44), suggesting co-circulation of these viruses. DENV and CHIKV exposure is lower in Qatar and MENA nationals compared to Asian nationals suggesting a lower burden of DENV and CHIKV disease in the MENA. Antibodies to both viruses were detected in nationals from most MENA countries, supporting the need to better understand the regional epidemiology of these viruses.</p><h2>Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0211574" target="_blank">https://dx.doi.org/10.1371/journal.pone.0211574</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d6c6dbffcda438d8e867d006f016ec33 |
| identifier_str_mv | 10.1371/journal.pone.0211574 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25347808 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in QatarJohn M. Humphrey (1601860)Enas S. Al-Absi (6281936)Munia M. Hamdan (6281939)Sara S. Okasha (6281942)Diyna M. Al-Trmanini (6281945)Hend G. El-Dous (6281948)Soha R. Dargham (3613250)John Schieffelin (3468986)Laith J. Abu-Raddad (9262524)Gheyath K. Nasrallah (9200525)Biomedical and clinical sciencesClinical sciencesanti-dengue (DENV)anti-chikungunya (CHIKV)Qatarantibodies<p dir="ltr">The objective of this study is to characterize the seroprevalence of anti-dengue (DENV) and anti-chikungunya (CHIKV) antibodies among blood donors residing in Qatar who are Middle East and North Africa (MENA) nationals and non-nationals. Sera were collected from adult blood donors in Qatar from 2013 to 2016 and tested for anti-DENV and anti-CHIKV IgG using commercial microplate enzyme-linked immunosorbent assays. Age-specific seroprevalence was summarized by region/nationality: Asia (India, Philippines), Middle East (Iran, Jordan, Lebanon, Pakistan, Palestine, Syria, Yemen), North Africa (Egypt, Sudan), Qatar. The adjusted odds of anti-DENV and anti-CHIKV IgG seropositivity was estimated by logistic regression. Among 1,992 serum samples tested, Asian nationals had higher adjusted odds of being seropositive for anti-DENV antibodies compared to nationals of the Middle East (aOR 0.05, 95% CI 0.04–0.07), North Africa (aOR 0.14, 95% CI 0.10–0.20), and Qatar (aOR 0.01, 95% CI 0.01–0.03). Asian nationals also had higher adjusted odds of being seropositive for anti-CHIKV antibodies compared to those from the Middle East (aOR 0.14, 95% CI 0.07–0.27), North Africa (aOR 0.50, 95% CI 0.26–0.96), and Qatar (aOR 0.38, 95% CI 0.15–0.96). The adjusted odds of being anti-DENV seropositive was higher among antiCHIKV seropositive adults, and vice versa (aOR 1.94, 95% CI 1.09–3.44), suggesting co-circulation of these viruses. DENV and CHIKV exposure is lower in Qatar and MENA nationals compared to Asian nationals suggesting a lower burden of DENV and CHIKV disease in the MENA. Antibodies to both viruses were detected in nationals from most MENA countries, supporting the need to better understand the regional epidemiology of these viruses.</p><h2>Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0211574" target="_blank">https://dx.doi.org/10.1371/journal.pone.0211574</a></p>2019-01-31T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1371/journal.pone.0211574https://figshare.com/articles/journal_contribution/Dengue_and_chikungunya_seroprevalence_among_Qatari_nationals_and_immigrants_residing_in_Qatar/25347808CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253478082019-01-31T03:00:00Z |
| spellingShingle | Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar John M. Humphrey (1601860) Biomedical and clinical sciences Clinical sciences anti-dengue (DENV) anti-chikungunya (CHIKV) Qatar antibodies |
| status_str | publishedVersion |
| title | Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar |
| title_full | Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar |
| title_fullStr | Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar |
| title_full_unstemmed | Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar |
| title_short | Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar |
| title_sort | Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar |
| topic | Biomedical and clinical sciences Clinical sciences anti-dengue (DENV) anti-chikungunya (CHIKV) Qatar antibodies |