Making Biomarkers Relevant to Healthcare Innovation and Precision Medicine
<p dir="ltr">Translational medicine, the exchange between laboratory (bench) and the clinic (bedside), is decidedly taking on a vital role. Many companies are now focusing on a translational medicinal approach as a therapeutic strategy in decision making upon realizing the expenses o...
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2022
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| _version_ | 1864513506089369600 |
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| author | Nader I. Al-Dewik (14152884) |
| author2 | Salma N. Younes (14153241) Musthafa Mohamed Essa (7348646) Surajit Pathak (12499) M. Walid Qoronfleh (14153088) |
| author2_role | author author author author |
| author_facet | Nader I. Al-Dewik (14152884) Salma N. Younes (14153241) Musthafa Mohamed Essa (7348646) Surajit Pathak (12499) M. Walid Qoronfleh (14153088) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nader I. Al-Dewik (14152884) Salma N. Younes (14153241) Musthafa Mohamed Essa (7348646) Surajit Pathak (12499) M. Walid Qoronfleh (14153088) |
| dc.date.none.fl_str_mv | 2022-06-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/pr10061107 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Making_Biomarkers_Relevant_to_Healthcare_Innovation_and_Precision_Medicine/26947018 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences precision medicine personalized medicine translational medicine biomarkers clinical trials cancer companion diagnostics therapy |
| dc.title.none.fl_str_mv | Making Biomarkers Relevant to Healthcare Innovation and Precision Medicine |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Translational medicine, the exchange between laboratory (bench) and the clinic (bedside), is decidedly taking on a vital role. Many companies are now focusing on a translational medicinal approach as a therapeutic strategy in decision making upon realizing the expenses of drug attrition in late-stage advancement. In addition, the utility of biomarkers in clinical decision and therapy guidance seeks to improve the patient outcomes and decrease wasteful and harmful treatment. Efficient biomarkers are crucial for the advancement of diagnoses, better molecular targeted therapy, along with therapeutic advantages in a broad spectrum of various diseases. Despite recent advances in the discovery of biomarkers, the advancement route to a clinically validated biomarker remains intensely challenging, and many of the candidate biomarkers do not progress to clinical applications, thereby widening the innovation gap between research and application. The present article will focus on the clinical view of biomarkers in a reverse design, addressing how a biomarker program should appear if it is expected to create an impact on personalized medicine and patient care.</p><h2>Other Information</h2><p dir="ltr">Published in: Processes<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/pr10061107" target="_blank">https://dx.doi.org/10.3390/pr10061107</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d7ceb30e745351af53190a4f2e8f125e |
| identifier_str_mv | 10.3390/pr10061107 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26947018 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Making Biomarkers Relevant to Healthcare Innovation and Precision MedicineNader I. Al-Dewik (14152884)Salma N. Younes (14153241)Musthafa Mohamed Essa (7348646)Surajit Pathak (12499)M. Walid Qoronfleh (14153088)Biomedical and clinical sciencesClinical sciencesPharmacology and pharmaceutical sciencesprecision medicinepersonalized medicinetranslational medicinebiomarkersclinical trialscancercompanion diagnosticstherapy<p dir="ltr">Translational medicine, the exchange between laboratory (bench) and the clinic (bedside), is decidedly taking on a vital role. Many companies are now focusing on a translational medicinal approach as a therapeutic strategy in decision making upon realizing the expenses of drug attrition in late-stage advancement. In addition, the utility of biomarkers in clinical decision and therapy guidance seeks to improve the patient outcomes and decrease wasteful and harmful treatment. Efficient biomarkers are crucial for the advancement of diagnoses, better molecular targeted therapy, along with therapeutic advantages in a broad spectrum of various diseases. Despite recent advances in the discovery of biomarkers, the advancement route to a clinically validated biomarker remains intensely challenging, and many of the candidate biomarkers do not progress to clinical applications, thereby widening the innovation gap between research and application. The present article will focus on the clinical view of biomarkers in a reverse design, addressing how a biomarker program should appear if it is expected to create an impact on personalized medicine and patient care.</p><h2>Other Information</h2><p dir="ltr">Published in: Processes<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/pr10061107" target="_blank">https://dx.doi.org/10.3390/pr10061107</a></p>2022-06-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/pr10061107https://figshare.com/articles/journal_contribution/Making_Biomarkers_Relevant_to_Healthcare_Innovation_and_Precision_Medicine/26947018CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/269470182022-06-01T00:00:00Z |
| spellingShingle | Making Biomarkers Relevant to Healthcare Innovation and Precision Medicine Nader I. Al-Dewik (14152884) Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences precision medicine personalized medicine translational medicine biomarkers clinical trials cancer companion diagnostics therapy |
| status_str | publishedVersion |
| title | Making Biomarkers Relevant to Healthcare Innovation and Precision Medicine |
| title_full | Making Biomarkers Relevant to Healthcare Innovation and Precision Medicine |
| title_fullStr | Making Biomarkers Relevant to Healthcare Innovation and Precision Medicine |
| title_full_unstemmed | Making Biomarkers Relevant to Healthcare Innovation and Precision Medicine |
| title_short | Making Biomarkers Relevant to Healthcare Innovation and Precision Medicine |
| title_sort | Making Biomarkers Relevant to Healthcare Innovation and Precision Medicine |
| topic | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences precision medicine personalized medicine translational medicine biomarkers clinical trials cancer companion diagnostics therapy |