Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature
<p dir="ltr">Gastric cancer, a multifactorial disease, is considered one of the most common malignancies worldwide. In addition to genetic and environmental risk factors, infectious agents, such as Epstein-Barr virus (EBV) and <i>Helicobacter pylori</i> (<i>H.pylori...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2023
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إضافة وسم
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| _version_ | 1864513561239224320 |
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| author | Tala M. Jamal Eddin (17012235) |
| author2 | Shahd M.O. Nasr (17012238) Ishita Gupta (9203073) Hatem Zayed (835448) Ala-Eddin Al Moustafa (14153205) |
| author2_role | author author author author |
| author_facet | Tala M. Jamal Eddin (17012235) Shahd M.O. Nasr (17012238) Ishita Gupta (9203073) Hatem Zayed (835448) Ala-Eddin Al Moustafa (14153205) |
| author_role | author |
| dc.creator.none.fl_str_mv | Tala M. Jamal Eddin (17012235) Shahd M.O. Nasr (17012238) Ishita Gupta (9203073) Hatem Zayed (835448) Ala-Eddin Al Moustafa (14153205) |
| dc.date.none.fl_str_mv | 2023-08-05T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.heliyon.2023.e18945 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Helicobacter_pylori_and_epithelial_mesenchymal_transition_in_human_gastric_cancers_An_update_of_the_literature/24166530 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Gastric cancer H.pylori Epithelial–mesenchymal transition Cancer progression |
| dc.title.none.fl_str_mv | Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Gastric cancer, a multifactorial disease, is considered one of the most common malignancies worldwide. In addition to genetic and environmental risk factors, infectious agents, such as Epstein-Barr virus (EBV) and <i>Helicobacter pylori</i> (<i>H.pylori</i>) contribute to the onset and development of gastric cancer. <i>H. pylori</i> is a type I carcinogen that colonizes the gastric epithelium of approximately 50% of the world's population, thus increasing the risk of gastric cancer development. On the other hand, epithelial mesenchymal transition (EMT) is a fundamental process crucial to embryogenic growth, wound healing, organ fibrosis and cancer progression. Several studies associate gastric pathogen infection of the epithelium with EMT initiation, provoking cancer metastasis in the gastric mucosa through various molecular signaling pathways. Additionally, EMT is implicated in the progression and development of <i>H. pylori</i>-associated gastric cancer. In this review, we recapitulate recent findings elucidating the association between <i>H. pylori</i> infection in EMT promotion leading to gastric cancer progression and metastasis.</p><h2>Other Information</h2><p dir="ltr">Published in: Heliyon<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.heliyon.2023.e18945" target="_blank">https://dx.doi.org/10.1016/j.heliyon.2023.e18945</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_d87683017883f538deee2bfb52843d91 |
| identifier_str_mv | 10.1016/j.heliyon.2023.e18945 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24166530 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literatureTala M. Jamal Eddin (17012235)Shahd M.O. Nasr (17012238)Ishita Gupta (9203073)Hatem Zayed (835448)Ala-Eddin Al Moustafa (14153205)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesGastric cancerH.pyloriEpithelial–mesenchymal transitionCancer progression<p dir="ltr">Gastric cancer, a multifactorial disease, is considered one of the most common malignancies worldwide. In addition to genetic and environmental risk factors, infectious agents, such as Epstein-Barr virus (EBV) and <i>Helicobacter pylori</i> (<i>H.pylori</i>) contribute to the onset and development of gastric cancer. <i>H. pylori</i> is a type I carcinogen that colonizes the gastric epithelium of approximately 50% of the world's population, thus increasing the risk of gastric cancer development. On the other hand, epithelial mesenchymal transition (EMT) is a fundamental process crucial to embryogenic growth, wound healing, organ fibrosis and cancer progression. Several studies associate gastric pathogen infection of the epithelium with EMT initiation, provoking cancer metastasis in the gastric mucosa through various molecular signaling pathways. Additionally, EMT is implicated in the progression and development of <i>H. pylori</i>-associated gastric cancer. In this review, we recapitulate recent findings elucidating the association between <i>H. pylori</i> infection in EMT promotion leading to gastric cancer progression and metastasis.</p><h2>Other Information</h2><p dir="ltr">Published in: Heliyon<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.heliyon.2023.e18945" target="_blank">https://dx.doi.org/10.1016/j.heliyon.2023.e18945</a></p>2023-08-05T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.heliyon.2023.e18945https://figshare.com/articles/journal_contribution/Helicobacter_pylori_and_epithelial_mesenchymal_transition_in_human_gastric_cancers_An_update_of_the_literature/24166530CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/241665302023-08-05T00:00:00Z |
| spellingShingle | Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature Tala M. Jamal Eddin (17012235) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Gastric cancer H.pylori Epithelial–mesenchymal transition Cancer progression |
| status_str | publishedVersion |
| title | Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature |
| title_full | Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature |
| title_fullStr | Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature |
| title_full_unstemmed | Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature |
| title_short | Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature |
| title_sort | Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Gastric cancer H.pylori Epithelial–mesenchymal transition Cancer progression |