Cathelicidin LL-37-induced transcriptome of human keratinocyte identifies chemokine CXCL10 link to T cell-mediated rosacea pathogenesis via JAK-1/STAT-1 pathway

Cathelicidin LL-37-induced transcriptome of human keratinocyte identifies chemokine CXCL10 link to T cell-mediated rosacea pathogenesis via JAK-1/STAT-1 pathway

<p dir="ltr">Rosacea is a chronic inflammatory disease of facial skin with unknown pathophysiology. Abnormal overexpression of human antimicrobial peptide LL-37 is a hallmark of rosacea. However, its significance in the rosacea pathogenesis is not fully understood. We sought to under...

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Bibliographic Details
Main Author: Abdul W. Ansari (14557391) (author)
Other Authors: Tanwir Habib (47644) (author), Fareed Ahmad (134672) (author), Thesni Raheed (17017779) (author), Cynthia Elizabeth (14152452) (author), Sara Al-Harami (22150180) (author), Anh Jochebeth (17017782) (author), Martin Steinhoff (5340194) (author)
Published: 2025
Subjects:
Biomedical and clinical sciences
Clinical sciences
Immunology
Rosacea
Pathophysiology
LL-37
CXCL10
T cell
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