Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights
<h3>Background and study aim </h3><p dir="ltr"><i>Helicobacter Pylori (H. pylori)</i>, a widespread gastric pathogen, can have a range of presentations necessitating population based tailored treatment strategies. We aimed to study the clinical and demographic...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2024
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| الموضوعات: | |
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| _version_ | 1864513541073010688 |
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| author | Zohaib A.W. Khan (22051949) |
| author2 | Hisham Ab Ib Swehli (22051952) Alia Hani Al-battah (22051955) Mohamed Mahmoud (4544233) Anil John (22051958) Khalid Al-Ejji (22051961) Saad Al Kaabi (18112780) Betsy Varughese (20376390) Rajvir Singh (315457) Shiraz Salim Khan (22051964) |
| author2_role | author author author author author author author author author |
| author_facet | Zohaib A.W. Khan (22051949) Hisham Ab Ib Swehli (22051952) Alia Hani Al-battah (22051955) Mohamed Mahmoud (4544233) Anil John (22051958) Khalid Al-Ejji (22051961) Saad Al Kaabi (18112780) Betsy Varughese (20376390) Rajvir Singh (315457) Shiraz Salim Khan (22051964) |
| author_role | author |
| dc.creator.none.fl_str_mv | Zohaib A.W. Khan (22051949) Hisham Ab Ib Swehli (22051952) Alia Hani Al-battah (22051955) Mohamed Mahmoud (4544233) Anil John (22051958) Khalid Al-Ejji (22051961) Saad Al Kaabi (18112780) Betsy Varughese (20376390) Rajvir Singh (315457) Shiraz Salim Khan (22051964) |
| dc.date.none.fl_str_mv | 2024-11-28T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.ajg.2024.07.007 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Population_based_treatment_strategy_of_H_pylori_in_Qatar_Through_clinical_and_demographic_insights/29907098 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Public health Helicobacter pylori Gastric malignancy Pre- malignancy Test and treat |
| dc.title.none.fl_str_mv | Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background and study aim </h3><p dir="ltr"><i>Helicobacter Pylori (H. pylori)</i>, a widespread gastric pathogen, can have a range of presentations necessitating population based tailored treatment strategies. We aimed to study the clinical and demographic profile of patients with H pylori in Qatar, to determine the best treatment strategy for Qatar’s population. </p><h3>Patients and methods</h3><p dir="ltr">Retrospective data collection of all patients diagnosed with H pylori from January 2017 to December 2019 in Hamad Medical Corporation (HMC) and Primary Health Care Corporation (PHCC), Qatar was done. The demographic, clinical, endoscopic and histologic characteristics of patients and H. Pylori directed therapies were documented and compared. Pearson’s Chi-square test, independent samples ttest or analysis of variance (ANOVA) was used as appropriate to compare various parameters between patients. </p><h3>Results</h3><p dir="ltr">2217 patients tested positive for <i>H. Pylori</i> over 3 yrs. of which 837 (37.8 %) were Qatari nationals. Dyspepsia was the most common indication for testing (44.6 % patients) which was positively associated with gastric erythema and atrophy on endoscopy (P = 0.000 and 0.004, respectively) and negatively associated with a normal endoscopy (p = 0.038). Most of the patients had chronic active gastritis (98.2 %). Other pre-malignancies were seen in only 85 (14.3 %) patients. Mean (SD) age of patients with premalignancies was significantly more than those without [ 53.25 (17.6) vs. 44.77 (14.8), p = 0.000]. Only 11(0.6 %) patients had a malignancy of the stomach. </p><h3>Conclusion </h3><p dir="ltr">H pylori infection may be quite prevalent amongst Qatari nationals. Since prevalence of gastric premalignancies and incidence of gastric malignancy in patients with H pylori in Qatar may be low, generalized test and treat strategy is not economically and practically meaningful in Qatar. Symptomatic patients should be tested and treated, with endoscopy reserved for those with alarming symptoms, failure of proton pump inhibitors and older patients.</p><h2>Other Information</h2><p dir="ltr">Published in: Arab Journal of Gastroenterology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ajg.2024.07.007" target="_blank">https://dx.doi.org/10.1016/j.ajg.2024.07.007</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_da4812d5a8c78961960066aacd47047b |
| identifier_str_mv | 10.1016/j.ajg.2024.07.007 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29907098 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insightsZohaib A.W. Khan (22051949)Hisham Ab Ib Swehli (22051952)Alia Hani Al-battah (22051955)Mohamed Mahmoud (4544233)Anil John (22051958)Khalid Al-Ejji (22051961)Saad Al Kaabi (18112780)Betsy Varughese (20376390)Rajvir Singh (315457)Shiraz Salim Khan (22051964)Biomedical and clinical sciencesClinical sciencesHealth sciencesEpidemiologyPublic healthHelicobacter pyloriGastric malignancyPre- malignancyTest and treat<h3>Background and study aim </h3><p dir="ltr"><i>Helicobacter Pylori (H. pylori)</i>, a widespread gastric pathogen, can have a range of presentations necessitating population based tailored treatment strategies. We aimed to study the clinical and demographic profile of patients with H pylori in Qatar, to determine the best treatment strategy for Qatar’s population. </p><h3>Patients and methods</h3><p dir="ltr">Retrospective data collection of all patients diagnosed with H pylori from January 2017 to December 2019 in Hamad Medical Corporation (HMC) and Primary Health Care Corporation (PHCC), Qatar was done. The demographic, clinical, endoscopic and histologic characteristics of patients and H. Pylori directed therapies were documented and compared. Pearson’s Chi-square test, independent samples ttest or analysis of variance (ANOVA) was used as appropriate to compare various parameters between patients. </p><h3>Results</h3><p dir="ltr">2217 patients tested positive for <i>H. Pylori</i> over 3 yrs. of which 837 (37.8 %) were Qatari nationals. Dyspepsia was the most common indication for testing (44.6 % patients) which was positively associated with gastric erythema and atrophy on endoscopy (P = 0.000 and 0.004, respectively) and negatively associated with a normal endoscopy (p = 0.038). Most of the patients had chronic active gastritis (98.2 %). Other pre-malignancies were seen in only 85 (14.3 %) patients. Mean (SD) age of patients with premalignancies was significantly more than those without [ 53.25 (17.6) vs. 44.77 (14.8), p = 0.000]. Only 11(0.6 %) patients had a malignancy of the stomach. </p><h3>Conclusion </h3><p dir="ltr">H pylori infection may be quite prevalent amongst Qatari nationals. Since prevalence of gastric premalignancies and incidence of gastric malignancy in patients with H pylori in Qatar may be low, generalized test and treat strategy is not economically and practically meaningful in Qatar. Symptomatic patients should be tested and treated, with endoscopy reserved for those with alarming symptoms, failure of proton pump inhibitors and older patients.</p><h2>Other Information</h2><p dir="ltr">Published in: Arab Journal of Gastroenterology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ajg.2024.07.007" target="_blank">https://dx.doi.org/10.1016/j.ajg.2024.07.007</a></p>2024-11-28T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.ajg.2024.07.007https://figshare.com/articles/journal_contribution/Population_based_treatment_strategy_of_H_pylori_in_Qatar_Through_clinical_and_demographic_insights/29907098CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/299070982024-11-28T09:00:00Z |
| spellingShingle | Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights Zohaib A.W. Khan (22051949) Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Public health Helicobacter pylori Gastric malignancy Pre- malignancy Test and treat |
| status_str | publishedVersion |
| title | Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights |
| title_full | Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights |
| title_fullStr | Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights |
| title_full_unstemmed | Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights |
| title_short | Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights |
| title_sort | Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights |
| topic | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Public health Helicobacter pylori Gastric malignancy Pre- malignancy Test and treat |