Recurrent spinal cord compression due to extramedullary hematopoiesis in thalassemia patient
<h3>Introduction</h3><p dir="ltr">Spinal cord compression secondary to extramedullary hematopoiesis (EMH) is a rare condition. Variable treatment options have been reported with different efficacy and recurrence rate. Due to its rarity, no clear optimal management guideli...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2022
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إضافة وسم
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| _version_ | 1864513548706643968 |
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| author | Shahem Abbarh (17945564) |
| author2 | Abdulrahman F. Al-Mashdali (17148316) Mohamed Abdelrazek (6903689) Venkada Manickam Gurusamy (17346805) Mohamed A. Yassin (8361183) |
| author2_role | author author author author |
| author_facet | Shahem Abbarh (17945564) Abdulrahman F. Al-Mashdali (17148316) Mohamed Abdelrazek (6903689) Venkada Manickam Gurusamy (17346805) Mohamed A. Yassin (8361183) |
| author_role | author |
| dc.creator.none.fl_str_mv | Shahem Abbarh (17945564) Abdulrahman F. Al-Mashdali (17148316) Mohamed Abdelrazek (6903689) Venkada Manickam Gurusamy (17346805) Mohamed A. Yassin (8361183) |
| dc.date.none.fl_str_mv | 2022-06-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1097/md.0000000000029334 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Recurrent_spinal_cord_compression_due_to_extramedullary_hematopoiesis_in_thalassemia_patient/29045393 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Neurosciences Oncology and carcinogenesis betal-thalassemia extramedullary hematopoiesis luspatercept radiotherapy spinal cord compression |
| dc.title.none.fl_str_mv | Recurrent spinal cord compression due to extramedullary hematopoiesis in thalassemia patient |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Introduction</h3><p dir="ltr">Spinal cord compression secondary to extramedullary hematopoiesis (EMH) is a rare condition. Variable treatment options have been reported with different efficacy and recurrence rate. Due to its rarity, no clear optimal management guidelines have been established yet.</p><h3>Patient concerns and diagnosis</h3><p dir="ltr">We report a recurrence of spinal cord compression secondary to EMH in a 19-year-old male, with a background of transfusion-dependent beta-thalassemia on luspatercept, who presented with weakness in both lower limbs.</p><h3>Interventions and outcomes</h3><p dir="ltr">He was treated successfully both times with radiotherapy.</p><h3>Conclusion</h3><p dir="ltr">Early diagnosis and management of EMH compressing the spinal cord are essential to prevent permanent neurological damage. Diagnosis should be suspected based on the clinical presentation and magnetic resonance imaging findings in a patient with a history of ineffective hemopoiesis. Treatment option remains controversial. Radiotherapy option seems effective, even in recurrent cases, and valid, particularly for those at high risk of surgery or who do not prefer it.</p><h2>Other Information</h2><p dir="ltr">Published in: Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1097/md.0000000000029334" target="_blank">https://dx.doi.org/10.1097/md.0000000000029334</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_daed54108b97fa2755bd122202f731ee |
| identifier_str_mv | 10.1097/md.0000000000029334 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29045393 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Recurrent spinal cord compression due to extramedullary hematopoiesis in thalassemia patientShahem Abbarh (17945564)Abdulrahman F. Al-Mashdali (17148316)Mohamed Abdelrazek (6903689)Venkada Manickam Gurusamy (17346805)Mohamed A. Yassin (8361183)Biomedical and clinical sciencesClinical sciencesNeurosciencesOncology and carcinogenesisbetal-thalassemiaextramedullary hematopoiesisluspaterceptradiotherapyspinal cord compression<h3>Introduction</h3><p dir="ltr">Spinal cord compression secondary to extramedullary hematopoiesis (EMH) is a rare condition. Variable treatment options have been reported with different efficacy and recurrence rate. Due to its rarity, no clear optimal management guidelines have been established yet.</p><h3>Patient concerns and diagnosis</h3><p dir="ltr">We report a recurrence of spinal cord compression secondary to EMH in a 19-year-old male, with a background of transfusion-dependent beta-thalassemia on luspatercept, who presented with weakness in both lower limbs.</p><h3>Interventions and outcomes</h3><p dir="ltr">He was treated successfully both times with radiotherapy.</p><h3>Conclusion</h3><p dir="ltr">Early diagnosis and management of EMH compressing the spinal cord are essential to prevent permanent neurological damage. Diagnosis should be suspected based on the clinical presentation and magnetic resonance imaging findings in a patient with a history of ineffective hemopoiesis. Treatment option remains controversial. Radiotherapy option seems effective, even in recurrent cases, and valid, particularly for those at high risk of surgery or who do not prefer it.</p><h2>Other Information</h2><p dir="ltr">Published in: Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1097/md.0000000000029334" target="_blank">https://dx.doi.org/10.1097/md.0000000000029334</a></p>2022-06-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1097/md.0000000000029334https://figshare.com/articles/journal_contribution/Recurrent_spinal_cord_compression_due_to_extramedullary_hematopoiesis_in_thalassemia_patient/29045393CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/290453932022-06-01T00:00:00Z |
| spellingShingle | Recurrent spinal cord compression due to extramedullary hematopoiesis in thalassemia patient Shahem Abbarh (17945564) Biomedical and clinical sciences Clinical sciences Neurosciences Oncology and carcinogenesis betal-thalassemia extramedullary hematopoiesis luspatercept radiotherapy spinal cord compression |
| status_str | publishedVersion |
| title | Recurrent spinal cord compression due to extramedullary hematopoiesis in thalassemia patient |
| title_full | Recurrent spinal cord compression due to extramedullary hematopoiesis in thalassemia patient |
| title_fullStr | Recurrent spinal cord compression due to extramedullary hematopoiesis in thalassemia patient |
| title_full_unstemmed | Recurrent spinal cord compression due to extramedullary hematopoiesis in thalassemia patient |
| title_short | Recurrent spinal cord compression due to extramedullary hematopoiesis in thalassemia patient |
| title_sort | Recurrent spinal cord compression due to extramedullary hematopoiesis in thalassemia patient |
| topic | Biomedical and clinical sciences Clinical sciences Neurosciences Oncology and carcinogenesis betal-thalassemia extramedullary hematopoiesis luspatercept radiotherapy spinal cord compression |