F-box proteins in cancer stemness: An emerging prognostic and therapeutic target
<p dir="ltr">Cancer is a complex heterogenic disease with significant therapeutic challenges. The presence of cancer stem cells (CSCs) in cancer tissue orchestrates tumor growth, progression, and metastasis, the tumor heterogeneity, disease relapse, and therapeutic resistance. Hence,...
محفوظ في:
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| مؤلفون آخرون: | , , |
| منشور في: |
2021
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إضافة وسم
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| _version_ | 1864513547033116672 |
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| author | Abdul Q. Khan (14153247) |
| author2 | Maha Al-Tamimi (17280550) Shahab Uddin (154400) Martin Steinhoff (5340194) |
| author2_role | author author author |
| author_facet | Abdul Q. Khan (14153247) Maha Al-Tamimi (17280550) Shahab Uddin (154400) Martin Steinhoff (5340194) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdul Q. Khan (14153247) Maha Al-Tamimi (17280550) Shahab Uddin (154400) Martin Steinhoff (5340194) |
| dc.date.none.fl_str_mv | 2021-12-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.drudis.2021.07.006 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/F-box_proteins_in_cancer_stemness_An_emerging_prognostic_and_therapeutic_target/24433117 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences F-box proteins and signaling Cancer pathogenesis Cancer stem cells Stemness Poor clinical outcomes |
| dc.title.none.fl_str_mv | F-box proteins in cancer stemness: An emerging prognostic and therapeutic target |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Cancer is a complex heterogenic disease with significant therapeutic challenges. The presence of cancer stem cells (CSCs) in cancer tissue orchestrates tumor growth, progression, and metastasis, the tumor heterogeneity, disease relapse, and therapeutic resistance. Hence, it is imperative to explore how progenitor or cancer-initiating cells acquire stemness features and reprogram different biological mechanisms to maintain their sustained oncogenicity. Interestingly, deregulation of F-box proteins (FBPs) is crucial for cancer stemness features, including drug resistance and disease relapse. In this review, we highlight recent updates on the clinical significance of targeting FBPs in cancer therapy, with emphasis on eliminating CSCs and associated therapeutic challenges. Moreover, we also discuss novel strategies for the selective elimination of CSCs by targeting FBPs.</p><h2>Other Information</h2><p dir="ltr">Published in: Drug Discovery Today<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.drudis.2021.07.006" target="_blank">https://dx.doi.org/10.1016/j.drudis.2021.07.006</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_db2474356bb9f0cea2c1d7f09548640e |
| identifier_str_mv | 10.1016/j.drudis.2021.07.006 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24433117 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | F-box proteins in cancer stemness: An emerging prognostic and therapeutic targetAbdul Q. Khan (14153247)Maha Al-Tamimi (17280550)Shahab Uddin (154400)Martin Steinhoff (5340194)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesF-box proteins and signalingCancer pathogenesisCancer stem cellsStemnessPoor clinical outcomes<p dir="ltr">Cancer is a complex heterogenic disease with significant therapeutic challenges. The presence of cancer stem cells (CSCs) in cancer tissue orchestrates tumor growth, progression, and metastasis, the tumor heterogeneity, disease relapse, and therapeutic resistance. Hence, it is imperative to explore how progenitor or cancer-initiating cells acquire stemness features and reprogram different biological mechanisms to maintain their sustained oncogenicity. Interestingly, deregulation of F-box proteins (FBPs) is crucial for cancer stemness features, including drug resistance and disease relapse. In this review, we highlight recent updates on the clinical significance of targeting FBPs in cancer therapy, with emphasis on eliminating CSCs and associated therapeutic challenges. Moreover, we also discuss novel strategies for the selective elimination of CSCs by targeting FBPs.</p><h2>Other Information</h2><p dir="ltr">Published in: Drug Discovery Today<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.drudis.2021.07.006" target="_blank">https://dx.doi.org/10.1016/j.drudis.2021.07.006</a></p>2021-12-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.drudis.2021.07.006https://figshare.com/articles/journal_contribution/F-box_proteins_in_cancer_stemness_An_emerging_prognostic_and_therapeutic_target/24433117CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/244331172021-12-01T00:00:00Z |
| spellingShingle | F-box proteins in cancer stemness: An emerging prognostic and therapeutic target Abdul Q. Khan (14153247) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences F-box proteins and signaling Cancer pathogenesis Cancer stem cells Stemness Poor clinical outcomes |
| status_str | publishedVersion |
| title | F-box proteins in cancer stemness: An emerging prognostic and therapeutic target |
| title_full | F-box proteins in cancer stemness: An emerging prognostic and therapeutic target |
| title_fullStr | F-box proteins in cancer stemness: An emerging prognostic and therapeutic target |
| title_full_unstemmed | F-box proteins in cancer stemness: An emerging prognostic and therapeutic target |
| title_short | F-box proteins in cancer stemness: An emerging prognostic and therapeutic target |
| title_sort | F-box proteins in cancer stemness: An emerging prognostic and therapeutic target |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences F-box proteins and signaling Cancer pathogenesis Cancer stem cells Stemness Poor clinical outcomes |