A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction

A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction

<h3>Aims</h3><p dir="ltr">Genome-wide association studies (GWAS) have consistently identified an association between coronary artery disease (CAD) and a locus on chromosome 10 containing a single gene, JCAD (formerly KIAA1462). However, little is known about the mechanism...

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Main Author: Gillian Douglas (7759118) (author)
Other Authors: Vedanta Mehta (590796) (author), Ayman Al Haj Zen (16614801) (author), Ioannis Akoumianakis (18597142) (author), Anuj Goel (258576) (author), Victoria S Rashbrook (18597145) (author), Lucy Trelfa (18597148) (author), Lucy Donovan (14495252) (author), Edward Drydale (18597151) (author), Surawee Chuaiphichai (659248) (author), Charalambos Antoniades (4126831) (author), Hugh Watkins (62729) (author), Theodosios Kyriakou (258572) (author), Ellie Tzima (641392) (author), Keith M Channon (13760659) (author)
Published: 2019
Subjects:
Biological sciences
Genetics
Biomedical and clinical sciences
Cardiovascular medicine and haematology
JCAD
Atherosclerosis
Shear stress
Endothelial cells
Kiaa1462
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