<i>SOD2</i>, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression
<p dir="ltr">CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44’s gene in the breast cancer (BC) cell line MCF-7...
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2022
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| _version_ | 1864513548307136512 |
|---|---|
| author | Nouralhuda Alateyah (21363215) |
| author2 | Ishita Gupta (9203073) Radoslaw Stefan Rusyniak (21363245) Allal Ouhtit (526) |
| author2_role | author author author |
| author_facet | Nouralhuda Alateyah (21363215) Ishita Gupta (9203073) Radoslaw Stefan Rusyniak (21363245) Allal Ouhtit (526) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nouralhuda Alateyah (21363215) Ishita Gupta (9203073) Radoslaw Stefan Rusyniak (21363245) Allal Ouhtit (526) |
| dc.date.none.fl_str_mv | 2022-01-26T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/molecules27030811 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/_i_SOD2_i_a_Potential_Transcriptional_Target_Underpinning_CD44-Promoted_Breast_Cancer_Progression/29069468 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis SOD2 CD44 hyaluronan breast cancer invasion |
| dc.title.none.fl_str_mv | <i>SOD2</i>, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44’s gene in the breast cancer (BC) cell line MCF-7 (B5 clone). Using cDNA oligo gene expression microarray, we identified <i>SOD2 </i>(superoxide dismutase 2) as a potential CD44-downstream transcriptional target involved in BC metastasis. <i>SOD2 </i> gene belongs to the family of iron/manganese superoxide dismutase family and encodes a mitochondrial protein. <i>SOD2</i> plays a role in cell proliferation and cell invasion via activation of different signaling pathways regulating angiogenic abilities of breast tumor cells. This review will focus on the findings supporting the underlying mechanisms associated with the oncogenic potential of <i>SOD2 </i> in the onset and progression of cancer, especially in BC and the potential clinical relevance of its various inhibitors.</p><h2>Other Information</h2><p dir="ltr">Published in: Molecules<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/molecules27030811" target="_blank">https://dx.doi.org/10.3390/molecules27030811</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_dc10bb080f30fc8f601c238591e7768c |
| identifier_str_mv | 10.3390/molecules27030811 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29069468 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | <i>SOD2</i>, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer ProgressionNouralhuda Alateyah (21363215)Ishita Gupta (9203073)Radoslaw Stefan Rusyniak (21363245)Allal Ouhtit (526)Biomedical and clinical sciencesOncology and carcinogenesisSOD2CD44hyaluronanbreast cancerinvasion<p dir="ltr">CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44’s gene in the breast cancer (BC) cell line MCF-7 (B5 clone). Using cDNA oligo gene expression microarray, we identified <i>SOD2 </i>(superoxide dismutase 2) as a potential CD44-downstream transcriptional target involved in BC metastasis. <i>SOD2 </i> gene belongs to the family of iron/manganese superoxide dismutase family and encodes a mitochondrial protein. <i>SOD2</i> plays a role in cell proliferation and cell invasion via activation of different signaling pathways regulating angiogenic abilities of breast tumor cells. This review will focus on the findings supporting the underlying mechanisms associated with the oncogenic potential of <i>SOD2 </i> in the onset and progression of cancer, especially in BC and the potential clinical relevance of its various inhibitors.</p><h2>Other Information</h2><p dir="ltr">Published in: Molecules<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/molecules27030811" target="_blank">https://dx.doi.org/10.3390/molecules27030811</a></p>2022-01-26T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/molecules27030811https://figshare.com/articles/journal_contribution/_i_SOD2_i_a_Potential_Transcriptional_Target_Underpinning_CD44-Promoted_Breast_Cancer_Progression/29069468CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/290694682022-01-26T09:00:00Z |
| spellingShingle | <i>SOD2</i>, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression Nouralhuda Alateyah (21363215) Biomedical and clinical sciences Oncology and carcinogenesis SOD2 CD44 hyaluronan breast cancer invasion |
| status_str | publishedVersion |
| title | <i>SOD2</i>, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression |
| title_full | <i>SOD2</i>, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression |
| title_fullStr | <i>SOD2</i>, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression |
| title_full_unstemmed | <i>SOD2</i>, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression |
| title_short | <i>SOD2</i>, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression |
| title_sort | <i>SOD2</i>, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis SOD2 CD44 hyaluronan breast cancer invasion |