CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson′s Disease
<p dir="ltr">In early-stage Parkinson′s disease (PD), cognitive impairment is common, and a variety of cognitive domains including memory, attention, and executive functioning may be affected. Cerebrospinal fluid (CSF) biomarkers are potential markers of cognitive functioning. We aim...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , , |
| منشور في: |
2020
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| الموضوعات: | |
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| _version_ | 1864513512260239360 |
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| author | Linda P. Oosterveld (18891679) |
| author2 | Tessa I. Kuiper (18891682) Nour K. Majbour (8809316) Inge M. W. Verberk (9736019) Karin D. van Dijk (18891685) Jos W. R. Twisk (8672904) Omar M. El-Agnaf (3172641) Charlotte E. Teunissen (7830647) Henry C. Weinstein (18286517) Martin Klein (119685) Henk W. Berendse (8809328) Wilma D. J. van de Berg (8809325) |
| author2_role | author author author author author author author author author author author |
| author_facet | Linda P. Oosterveld (18891679) Tessa I. Kuiper (18891682) Nour K. Majbour (8809316) Inge M. W. Verberk (9736019) Karin D. van Dijk (18891685) Jos W. R. Twisk (8672904) Omar M. El-Agnaf (3172641) Charlotte E. Teunissen (7830647) Henry C. Weinstein (18286517) Martin Klein (119685) Henk W. Berendse (8809328) Wilma D. J. van de Berg (8809325) |
| author_role | author |
| dc.creator.none.fl_str_mv | Linda P. Oosterveld (18891679) Tessa I. Kuiper (18891682) Nour K. Majbour (8809316) Inge M. W. Verberk (9736019) Karin D. van Dijk (18891685) Jos W. R. Twisk (8672904) Omar M. El-Agnaf (3172641) Charlotte E. Teunissen (7830647) Henry C. Weinstein (18286517) Martin Klein (119685) Henk W. Berendse (8809328) Wilma D. J. van de Berg (8809325) |
| dc.date.none.fl_str_mv | 2020-11-12T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijms21228519 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/CSF_Biomarkers_Reflecting_Protein_Pathology_and_Axonal_Degeneration_Are_Associated_with_Memory_Attentional_and_Executive_Functioning_in_Early-Stage_Parkinson_s_Disease/26114446 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences CSF biomarkers cognitive impairment neuropsychological testing Parkinson′s disease |
| dc.title.none.fl_str_mv | CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson′s Disease |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">In early-stage Parkinson′s disease (PD), cognitive impairment is common, and a variety of cognitive domains including memory, attention, and executive functioning may be affected. Cerebrospinal fluid (CSF) biomarkers are potential markers of cognitive functioning. We aimed to explore whether CSF α-synuclein species, neurofilament light chain, amyloid-β42, and tau are associated with cognitive performance in early-stage PD patients. CSF levels of total-α-synuclein and phosphorylated-α-synuclein, neurofilament light chain, amyloid-β42, and total-tau and phosphorylated-tau were measured in 26 PD patients (disease duration ≤5 years and Hoehn and Yahr stage 1–2.5). Multivariable linear regression models, adjusted for age, gender, and educational level, were used to assess the relationship between CSF biomarker levels and memory, attention, executive and visuospatial function, and language performance scores. In 26 early-stage PD patients, attention and memory were the most commonly affected domains. A higher CSF phosphorylated-α-synuclein/total-α-synuclein ratio was associated with better executive functioning (sβ = 0.40). Higher CSF neurofilament light was associated with worse memory (sβ = −0.59), attentional (sβ = −0.32), and executive functioning (sβ = −0.35). Reduced CSF amyloid-β42 levels were associated with poorer attentional functioning (sβ = 0.35). Higher CSF phosphorylated-tau was associated with worse language functioning (sβ = −0.33). Thus, CSF biomarker levels, in particular neurofilament light, were related to the most commonly affected cognitive domains in early-stage PD. This indicates that CSF biomarker levels may identify early-stage PD patients who are at an increased risk of developing cognitive impairment.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Molecular Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms21228519" target="_blank">https://dx.doi.org/10.3390/ijms21228519</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_dc28a77d50852d9a7e10f3e3a70dcba0 |
| identifier_str_mv | 10.3390/ijms21228519 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26114446 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson′s DiseaseLinda P. Oosterveld (18891679)Tessa I. Kuiper (18891682)Nour K. Majbour (8809316)Inge M. W. Verberk (9736019)Karin D. van Dijk (18891685)Jos W. R. Twisk (8672904)Omar M. El-Agnaf (3172641)Charlotte E. Teunissen (7830647)Henry C. Weinstein (18286517)Martin Klein (119685)Henk W. Berendse (8809328)Wilma D. J. van de Berg (8809325)Biomedical and clinical sciencesNeurosciencesCSF biomarkerscognitive impairmentneuropsychological testingParkinson′s disease<p dir="ltr">In early-stage Parkinson′s disease (PD), cognitive impairment is common, and a variety of cognitive domains including memory, attention, and executive functioning may be affected. Cerebrospinal fluid (CSF) biomarkers are potential markers of cognitive functioning. We aimed to explore whether CSF α-synuclein species, neurofilament light chain, amyloid-β42, and tau are associated with cognitive performance in early-stage PD patients. CSF levels of total-α-synuclein and phosphorylated-α-synuclein, neurofilament light chain, amyloid-β42, and total-tau and phosphorylated-tau were measured in 26 PD patients (disease duration ≤5 years and Hoehn and Yahr stage 1–2.5). Multivariable linear regression models, adjusted for age, gender, and educational level, were used to assess the relationship between CSF biomarker levels and memory, attention, executive and visuospatial function, and language performance scores. In 26 early-stage PD patients, attention and memory were the most commonly affected domains. A higher CSF phosphorylated-α-synuclein/total-α-synuclein ratio was associated with better executive functioning (sβ = 0.40). Higher CSF neurofilament light was associated with worse memory (sβ = −0.59), attentional (sβ = −0.32), and executive functioning (sβ = −0.35). Reduced CSF amyloid-β42 levels were associated with poorer attentional functioning (sβ = 0.35). Higher CSF phosphorylated-tau was associated with worse language functioning (sβ = −0.33). Thus, CSF biomarker levels, in particular neurofilament light, were related to the most commonly affected cognitive domains in early-stage PD. This indicates that CSF biomarker levels may identify early-stage PD patients who are at an increased risk of developing cognitive impairment.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Molecular Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms21228519" target="_blank">https://dx.doi.org/10.3390/ijms21228519</a></p>2020-11-12T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijms21228519https://figshare.com/articles/journal_contribution/CSF_Biomarkers_Reflecting_Protein_Pathology_and_Axonal_Degeneration_Are_Associated_with_Memory_Attentional_and_Executive_Functioning_in_Early-Stage_Parkinson_s_Disease/26114446CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/261144462020-11-12T06:00:00Z |
| spellingShingle | CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson′s Disease Linda P. Oosterveld (18891679) Biomedical and clinical sciences Neurosciences CSF biomarkers cognitive impairment neuropsychological testing Parkinson′s disease |
| status_str | publishedVersion |
| title | CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson′s Disease |
| title_full | CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson′s Disease |
| title_fullStr | CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson′s Disease |
| title_full_unstemmed | CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson′s Disease |
| title_short | CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson′s Disease |
| title_sort | CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson′s Disease |
| topic | Biomedical and clinical sciences Neurosciences CSF biomarkers cognitive impairment neuropsychological testing Parkinson′s disease |