Autoantibodies - enemies, and/or potential allies?
<div><p>Autoantibodies are well known as potentially highly harmful antibodies which attack the host via binding to self-antigens, thus causing severe associated diseases and symptoms (e.g. autoimmune diseases). However, detection of autoantibodies to a range of disease-associated antige...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , |
| منشور في: |
2022
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513518722613248 |
|---|---|
| author | Hui Ma (290168) |
| author2 | Caroline Murphy (3440597) Christine E. Loscher (18420831) Richard O’Kennedy (713891) |
| author2_role | author author author |
| author_facet | Hui Ma (290168) Caroline Murphy (3440597) Christine E. Loscher (18420831) Richard O’Kennedy (713891) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hui Ma (290168) Caroline Murphy (3440597) Christine E. Loscher (18420831) Richard O’Kennedy (713891) |
| dc.date.none.fl_str_mv | 2022-10-19T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fimmu.2022.953726 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Autoantibodies_-_enemies_and_or_potential_allies_/25662645 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology autoantibody diagnosis treatment autoimmune disease cancer COVID - 19 biomarker |
| dc.title.none.fl_str_mv | Autoantibodies - enemies, and/or potential allies? |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Autoantibodies are well known as potentially highly harmful antibodies which attack the host via binding to self-antigens, thus causing severe associated diseases and symptoms (e.g. autoimmune diseases). However, detection of autoantibodies to a range of disease-associated antigens has enabled their successful usage as important tools in disease diagnosis, prognosis and treatment. There are several advantages of using such autoantibodies. These include the capacity to measure their presence very early in disease development, their stability, which is often much better than their related antigen, and the capacity to use an array of such autoantibodies for enhanced diagnostics and to better predict prognosis. They may also possess capacity for utilization in therapy, in vivo. In this review both the positive and negative aspects of autoantibodies are critically assessed, including their role in autoimmune diseases, cancers and the global pandemic caused by COVID-19. Important issues related to their detection are also highlighted.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Frontiers in Immunology<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fimmu.2022.953726" target="_blank">https://dx.doi.org/10.3389/fimmu.2022.953726</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_dce46aaeaf0b515f7b55e453dfdc575f |
| identifier_str_mv | 10.3389/fimmu.2022.953726 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25662645 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Autoantibodies - enemies, and/or potential allies?Hui Ma (290168)Caroline Murphy (3440597)Christine E. Loscher (18420831)Richard O’Kennedy (713891)Biomedical and clinical sciencesImmunologyautoantibodydiagnosistreatmentautoimmune diseasecancerCOVID - 19biomarker<div><p>Autoantibodies are well known as potentially highly harmful antibodies which attack the host via binding to self-antigens, thus causing severe associated diseases and symptoms (e.g. autoimmune diseases). However, detection of autoantibodies to a range of disease-associated antigens has enabled their successful usage as important tools in disease diagnosis, prognosis and treatment. There are several advantages of using such autoantibodies. These include the capacity to measure their presence very early in disease development, their stability, which is often much better than their related antigen, and the capacity to use an array of such autoantibodies for enhanced diagnostics and to better predict prognosis. They may also possess capacity for utilization in therapy, in vivo. In this review both the positive and negative aspects of autoantibodies are critically assessed, including their role in autoimmune diseases, cancers and the global pandemic caused by COVID-19. Important issues related to their detection are also highlighted.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Frontiers in Immunology<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fimmu.2022.953726" target="_blank">https://dx.doi.org/10.3389/fimmu.2022.953726</a></p>2022-10-19T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fimmu.2022.953726https://figshare.com/articles/journal_contribution/Autoantibodies_-_enemies_and_or_potential_allies_/25662645CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/256626452022-10-19T03:00:00Z |
| spellingShingle | Autoantibodies - enemies, and/or potential allies? Hui Ma (290168) Biomedical and clinical sciences Immunology autoantibody diagnosis treatment autoimmune disease cancer COVID - 19 biomarker |
| status_str | publishedVersion |
| title | Autoantibodies - enemies, and/or potential allies? |
| title_full | Autoantibodies - enemies, and/or potential allies? |
| title_fullStr | Autoantibodies - enemies, and/or potential allies? |
| title_full_unstemmed | Autoantibodies - enemies, and/or potential allies? |
| title_short | Autoantibodies - enemies, and/or potential allies? |
| title_sort | Autoantibodies - enemies, and/or potential allies? |
| topic | Biomedical and clinical sciences Immunology autoantibody diagnosis treatment autoimmune disease cancer COVID - 19 biomarker |