Development of titanium dioxide nanowire incorporated poly(vinylidene fluoride–trifluoroethylene) scaffolds for bone tissue engineering applications
<p dir="ltr">Critical size bone defects that do not heal spontaneously are among the major reasons for the disability in majority of people with locomotor disabilities. Tissue engineering has become a promising approach for repairing such large tissue injuries including critical size...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , |
| Published: |
2019
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513567615614976 |
|---|---|
| author | Anitha Augustine (14151195) |
| author2 | Robin Augustine (3976964) Anwarul Hasan (1332066) Varun Raghuveeran (14151201) Didier Rouxel (2238361) Nandakumar Kalarikkal (4962604) Sabu Thomas (1815610) |
| author2_role | author author author author author author |
| author_facet | Anitha Augustine (14151195) Robin Augustine (3976964) Anwarul Hasan (1332066) Varun Raghuveeran (14151201) Didier Rouxel (2238361) Nandakumar Kalarikkal (4962604) Sabu Thomas (1815610) |
| author_role | author |
| dc.creator.none.fl_str_mv | Anitha Augustine (14151195) Robin Augustine (3976964) Anwarul Hasan (1332066) Varun Raghuveeran (14151201) Didier Rouxel (2238361) Nandakumar Kalarikkal (4962604) Sabu Thomas (1815610) |
| dc.date.none.fl_str_mv | 2019-08-14T21:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s10856-019-6300-4 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Development_of_titanium_dioxide_nanowire_incorporated_poly_vinylidene_fluoride_trifluoroethylene_scaffolds_for_bone_tissue_engineering_applications/21597336 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Engineering Biomedical engineering Biomedical Engineering Biomaterials Bioengineering Biophysics |
| dc.title.none.fl_str_mv | Development of titanium dioxide nanowire incorporated poly(vinylidene fluoride–trifluoroethylene) scaffolds for bone tissue engineering applications |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Critical size bone defects that do not heal spontaneously are among the major reasons for the disability in majority of people with locomotor disabilities. Tissue engineering has become a promising approach for repairing such large tissue injuries including critical size bone defects. Three-dimension (3D) porous scaffolds based on piezoelectric polymers like poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) have received a lot of attention in bone tissue engineering due to their favorable osteogenic properties. Owing to the favourable redox properties, titanium dioxide (TiO<sub>2</sub>) nanostructures have gained a great deal of attention in bone tissue engineering. In this paper, tissue engineering scaffolds based on P(VDF-TrFE) loaded with TiO<sub>2</sub> nanowires (TNW) were developed and evaluated for bone tissue engineering. Wet-chemical method was used for the synthesis of TNW. Obtained TNW were thoroughly characterized for the physicochemical and morphological properties using techniques such as X-Ray diffraction (XRD) analysis and transmission electron microscopy (TEM). Electrospinning was used to produce TNW incorporated P(VDF-TrFE) scaffolds. Developed scaffolds were characterized by state of art techniques such as Scanning Electron Microscopy (SEM), XRD and Differential scanning calorimetry (DSC) analyses. TEM analysis revealed that the obtained TiO<sub>2</sub> nanostructures possess nanofibrous morphology with an average diameter of 26 ± 4 nm. Results of characterization of nanocomposite scaffolds confirmed the effective loading of TNW in P(VDF-TrFE) matrix. Fabricated P(VDF-TrFE)/TNW scaffolds possessed good mechanical strength and cytocompatibility. Osteoblast like cells showed higher adhesion and proliferation on the nanocomposite scaffolds. This investigation revealed that the developed P(VDF-TrFE) scaffolds containing TNW can be used as potential scaffolds for bone tissue engineering applications.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Materials Science: Materials in Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s10856-019-6300-4" target="_blank">http://dx.doi.org/10.1007/s10856-019-6300-4</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_dd219da436fb2ad86e49843793f674fa |
| identifier_str_mv | 10.1007/s10856-019-6300-4 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21597336 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Development of titanium dioxide nanowire incorporated poly(vinylidene fluoride–trifluoroethylene) scaffolds for bone tissue engineering applicationsAnitha Augustine (14151195)Robin Augustine (3976964)Anwarul Hasan (1332066)Varun Raghuveeran (14151201)Didier Rouxel (2238361)Nandakumar Kalarikkal (4962604)Sabu Thomas (1815610)EngineeringBiomedical engineeringBiomedical EngineeringBiomaterialsBioengineeringBiophysics<p dir="ltr">Critical size bone defects that do not heal spontaneously are among the major reasons for the disability in majority of people with locomotor disabilities. Tissue engineering has become a promising approach for repairing such large tissue injuries including critical size bone defects. Three-dimension (3D) porous scaffolds based on piezoelectric polymers like poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) have received a lot of attention in bone tissue engineering due to their favorable osteogenic properties. Owing to the favourable redox properties, titanium dioxide (TiO<sub>2</sub>) nanostructures have gained a great deal of attention in bone tissue engineering. In this paper, tissue engineering scaffolds based on P(VDF-TrFE) loaded with TiO<sub>2</sub> nanowires (TNW) were developed and evaluated for bone tissue engineering. Wet-chemical method was used for the synthesis of TNW. Obtained TNW were thoroughly characterized for the physicochemical and morphological properties using techniques such as X-Ray diffraction (XRD) analysis and transmission electron microscopy (TEM). Electrospinning was used to produce TNW incorporated P(VDF-TrFE) scaffolds. Developed scaffolds were characterized by state of art techniques such as Scanning Electron Microscopy (SEM), XRD and Differential scanning calorimetry (DSC) analyses. TEM analysis revealed that the obtained TiO<sub>2</sub> nanostructures possess nanofibrous morphology with an average diameter of 26 ± 4 nm. Results of characterization of nanocomposite scaffolds confirmed the effective loading of TNW in P(VDF-TrFE) matrix. Fabricated P(VDF-TrFE)/TNW scaffolds possessed good mechanical strength and cytocompatibility. Osteoblast like cells showed higher adhesion and proliferation on the nanocomposite scaffolds. This investigation revealed that the developed P(VDF-TrFE) scaffolds containing TNW can be used as potential scaffolds for bone tissue engineering applications.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Materials Science: Materials in Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s10856-019-6300-4" target="_blank">http://dx.doi.org/10.1007/s10856-019-6300-4</a></p>2019-08-14T21:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s10856-019-6300-4https://figshare.com/articles/journal_contribution/Development_of_titanium_dioxide_nanowire_incorporated_poly_vinylidene_fluoride_trifluoroethylene_scaffolds_for_bone_tissue_engineering_applications/21597336CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215973362019-08-14T21:00:00Z |
| spellingShingle | Development of titanium dioxide nanowire incorporated poly(vinylidene fluoride–trifluoroethylene) scaffolds for bone tissue engineering applications Anitha Augustine (14151195) Engineering Biomedical engineering Biomedical Engineering Biomaterials Bioengineering Biophysics |
| status_str | publishedVersion |
| title | Development of titanium dioxide nanowire incorporated poly(vinylidene fluoride–trifluoroethylene) scaffolds for bone tissue engineering applications |
| title_full | Development of titanium dioxide nanowire incorporated poly(vinylidene fluoride–trifluoroethylene) scaffolds for bone tissue engineering applications |
| title_fullStr | Development of titanium dioxide nanowire incorporated poly(vinylidene fluoride–trifluoroethylene) scaffolds for bone tissue engineering applications |
| title_full_unstemmed | Development of titanium dioxide nanowire incorporated poly(vinylidene fluoride–trifluoroethylene) scaffolds for bone tissue engineering applications |
| title_short | Development of titanium dioxide nanowire incorporated poly(vinylidene fluoride–trifluoroethylene) scaffolds for bone tissue engineering applications |
| title_sort | Development of titanium dioxide nanowire incorporated poly(vinylidene fluoride–trifluoroethylene) scaffolds for bone tissue engineering applications |
| topic | Engineering Biomedical engineering Biomedical Engineering Biomaterials Bioengineering Biophysics |