Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
<div><p>Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account for the high mortality rate. The tumor microenvironment...
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| مؤلفون آخرون: | , , , , , , , , , , , , , , , , , , |
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2021
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| _version_ | 1864513517747437568 |
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| author | Ajaz A. Bhat (12984701) |
| author2 | Sabah Nisar (12561961) Selma Maacha (501715) Tatiana Correa Carneiro-Lobo (18459033) Sabah Akhtar (5809925) Kodappully Sivaraman Siveen (9440771) Nissar A. Wani (15070399) Arshi Rizwan (18278773) Puneet Bagga (4055866) Mayank Singh (793077) Ravinder Reddy (564813) Shahab Uddin (154400) Jean-Charles Grivel (284645) Gyan Chand (452737) Michael P. Frenneaux (9538623) Mushtaq A. Siddiqi (18459036) Davide Bedognetti (2632474) Wael El-Rifai (303374) Muzafar A. Macha (11605200) Mohammad Haris (564809) |
| author2_role | author author author author author author author author author author author author author author author author author author author |
| author_facet | Ajaz A. Bhat (12984701) Sabah Nisar (12561961) Selma Maacha (501715) Tatiana Correa Carneiro-Lobo (18459033) Sabah Akhtar (5809925) Kodappully Sivaraman Siveen (9440771) Nissar A. Wani (15070399) Arshi Rizwan (18278773) Puneet Bagga (4055866) Mayank Singh (793077) Ravinder Reddy (564813) Shahab Uddin (154400) Jean-Charles Grivel (284645) Gyan Chand (452737) Michael P. Frenneaux (9538623) Mushtaq A. Siddiqi (18459036) Davide Bedognetti (2632474) Wael El-Rifai (303374) Muzafar A. Macha (11605200) Mohammad Haris (564809) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ajaz A. Bhat (12984701) Sabah Nisar (12561961) Selma Maacha (501715) Tatiana Correa Carneiro-Lobo (18459033) Sabah Akhtar (5809925) Kodappully Sivaraman Siveen (9440771) Nissar A. Wani (15070399) Arshi Rizwan (18278773) Puneet Bagga (4055866) Mayank Singh (793077) Ravinder Reddy (564813) Shahab Uddin (154400) Jean-Charles Grivel (284645) Gyan Chand (452737) Michael P. Frenneaux (9538623) Mushtaq A. Siddiqi (18459036) Davide Bedognetti (2632474) Wael El-Rifai (303374) Muzafar A. Macha (11605200) Mohammad Haris (564809) |
| dc.date.none.fl_str_mv | 2021-01-04T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12943-020-01294-3 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Cytokine-chemokine_network_driven_metastasis_in_esophageal_cancer_promising_avenue_for_targeted_therapy/25712295 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Oncology and carcinogenesis Esophageal cancer Cytokines Chemokines Inflammation Tumor microenvironment Epithelial-Mesenchymal transition Drug targets Immune evasion |
| dc.title.none.fl_str_mv | Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account for the high mortality rate. The tumor microenvironment (TME) contains several cell types, including fibroblasts, immune cells, adipocytes, stromal proteins, and growth factors, which play a significant role in supporting the growth and aggressive behavior of cancer cells. The complex and dynamic interactions of the secreted cytokines, chemokines, growth factors, and their receptors mediate chronic inflammation and immunosuppressive TME favoring tumor progression, metastasis, and decreased response to therapy. The molecular changes in the TME are used as biological markers for diagnosis, prognosis, and response to treatment in patients. This review highlighted the novel insights into the understanding and functional impact of deregulated cytokines and chemokines in imparting aggressive EC, stressing the nature and therapeutic consequences of the cytokine-chemokine network. We also discuss cytokine-chemokine oncogenic potential by contributing to the Epithelial-Mesenchymal Transition (EMT), angiogenesis, immunosuppression, metastatic niche, and therapeutic resistance development. In addition, it discusses the wide range of changes and intracellular signaling pathways that occur in the TME. Overall, this is a relatively unexplored field that could provide crucial insights into tumor immunology and encourage the effective application of modulatory cytokine-chemokine therapy to EC.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Molecular Cancer<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12943-020-01294-3" target="_blank">https://dx.doi.org/10.1186/s12943-020-01294-3</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_dda9e9f266b036a3b606ba20258fae0e |
| identifier_str_mv | 10.1186/s12943-020-01294-3 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25712295 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapyAjaz A. Bhat (12984701)Sabah Nisar (12561961)Selma Maacha (501715)Tatiana Correa Carneiro-Lobo (18459033)Sabah Akhtar (5809925)Kodappully Sivaraman Siveen (9440771)Nissar A. Wani (15070399)Arshi Rizwan (18278773)Puneet Bagga (4055866)Mayank Singh (793077)Ravinder Reddy (564813)Shahab Uddin (154400)Jean-Charles Grivel (284645)Gyan Chand (452737)Michael P. Frenneaux (9538623)Mushtaq A. Siddiqi (18459036)Davide Bedognetti (2632474)Wael El-Rifai (303374)Muzafar A. Macha (11605200)Mohammad Haris (564809)Biomedical and clinical sciencesImmunologyOncology and carcinogenesisEsophageal cancerCytokinesChemokinesInflammationTumor microenvironmentEpithelial-Mesenchymal transitionDrug targetsImmune evasion<div><p>Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account for the high mortality rate. The tumor microenvironment (TME) contains several cell types, including fibroblasts, immune cells, adipocytes, stromal proteins, and growth factors, which play a significant role in supporting the growth and aggressive behavior of cancer cells. The complex and dynamic interactions of the secreted cytokines, chemokines, growth factors, and their receptors mediate chronic inflammation and immunosuppressive TME favoring tumor progression, metastasis, and decreased response to therapy. The molecular changes in the TME are used as biological markers for diagnosis, prognosis, and response to treatment in patients. This review highlighted the novel insights into the understanding and functional impact of deregulated cytokines and chemokines in imparting aggressive EC, stressing the nature and therapeutic consequences of the cytokine-chemokine network. We also discuss cytokine-chemokine oncogenic potential by contributing to the Epithelial-Mesenchymal Transition (EMT), angiogenesis, immunosuppression, metastatic niche, and therapeutic resistance development. In addition, it discusses the wide range of changes and intracellular signaling pathways that occur in the TME. Overall, this is a relatively unexplored field that could provide crucial insights into tumor immunology and encourage the effective application of modulatory cytokine-chemokine therapy to EC.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Molecular Cancer<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12943-020-01294-3" target="_blank">https://dx.doi.org/10.1186/s12943-020-01294-3</a></p>2021-01-04T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12943-020-01294-3https://figshare.com/articles/journal_contribution/Cytokine-chemokine_network_driven_metastasis_in_esophageal_cancer_promising_avenue_for_targeted_therapy/25712295CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/257122952021-01-04T03:00:00Z |
| spellingShingle | Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy Ajaz A. Bhat (12984701) Biomedical and clinical sciences Immunology Oncology and carcinogenesis Esophageal cancer Cytokines Chemokines Inflammation Tumor microenvironment Epithelial-Mesenchymal transition Drug targets Immune evasion |
| status_str | publishedVersion |
| title | Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy |
| title_full | Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy |
| title_fullStr | Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy |
| title_full_unstemmed | Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy |
| title_short | Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy |
| title_sort | Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy |
| topic | Biomedical and clinical sciences Immunology Oncology and carcinogenesis Esophageal cancer Cytokines Chemokines Inflammation Tumor microenvironment Epithelial-Mesenchymal transition Drug targets Immune evasion |