Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells
<p>Cancer remains one of the leading causes of mortality worldwide, presenting a significant healthcare challenge owing to the limited efficacy of current treatments. The application of nanotechnology in cancer treatment leverages the unique optical, magnetic, and electrical attributes of nano...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2023
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| _version_ | 1864513529424379904 |
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| author | Queenie Fernandes (14557388) |
| author2 | Lubna Therachiyil (4246156) Abdul Q. Khan (14153247) Takwa Bedhiafi (14153460) Hesham M Korashy (17823662) Ajaz A. Bhat (12984701) Shahab Uddin (154400) |
| author2_role | author author author author author author |
| author_facet | Queenie Fernandes (14557388) Lubna Therachiyil (4246156) Abdul Q. Khan (14153247) Takwa Bedhiafi (14153460) Hesham M Korashy (17823662) Ajaz A. Bhat (12984701) Shahab Uddin (154400) |
| author_role | author |
| dc.creator.none.fl_str_mv | Queenie Fernandes (14557388) Lubna Therachiyil (4246156) Abdul Q. Khan (14153247) Takwa Bedhiafi (14153460) Hesham M Korashy (17823662) Ajaz A. Bhat (12984701) Shahab Uddin (154400) |
| dc.date.none.fl_str_mv | 2023-12-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.ejps.2023.106586 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Shrinking_the_battlefield_in_cancer_therapy_Nanotechnology_against_cancer_stem_cells/25038497 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Nanotechnology Nanotherapy Cancer stem cells Signaling pathways Pharmacokinetics Drug resistance |
| dc.title.none.fl_str_mv | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Cancer remains one of the leading causes of mortality worldwide, presenting a significant healthcare challenge owing to the limited efficacy of current treatments. The application of nanotechnology in cancer treatment leverages the unique optical, magnetic, and electrical attributes of nanomaterials to engineer innovative, targeted therapies. Specifically, manipulating nanomaterials allows for enhanced drug loading efficiency, improved bioavailability, and targeted delivery systems, reducing the non-specific cytotoxic effects characteristic of conventional chemotherapies. Furthermore, recent advances in nanotechnology have demonstrated encouraging results in specifically targeting CSCs, a key development considering the role of these cells in disease recurrence and resistance to treatment. Despite these breakthroughs, the clinical approval rates of nano-drugs have not kept pace with research advances, pointing to existing obstacles that must be addressed. In conclusion, nanotechnology presents a novel, powerful tool in the fight against cancer, particularly in targeting the elusive and treatment-resistant CSCs. This comprehensive review delves into the intricacies of nanotherapy, explicitly targeting cancer stem cells, their markers, and associated signaling pathways.</p><h2>Other Information</h2> <p> Published in: European Journal of Pharmaceutical Sciences<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ejps.2023.106586" target="_blank">https://dx.doi.org/10.1016/j.ejps.2023.106586</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ddc8b48498cb211daad97430c1c1f230 |
| identifier_str_mv | 10.1016/j.ejps.2023.106586 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25038497 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cellsQueenie Fernandes (14557388)Lubna Therachiyil (4246156)Abdul Q. Khan (14153247)Takwa Bedhiafi (14153460)Hesham M Korashy (17823662)Ajaz A. Bhat (12984701)Shahab Uddin (154400)Biomedical and clinical sciencesClinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesEngineeringBiomedical engineeringNanotechnologyNanotherapyCancer stem cellsSignaling pathwaysPharmacokineticsDrug resistance<p>Cancer remains one of the leading causes of mortality worldwide, presenting a significant healthcare challenge owing to the limited efficacy of current treatments. The application of nanotechnology in cancer treatment leverages the unique optical, magnetic, and electrical attributes of nanomaterials to engineer innovative, targeted therapies. Specifically, manipulating nanomaterials allows for enhanced drug loading efficiency, improved bioavailability, and targeted delivery systems, reducing the non-specific cytotoxic effects characteristic of conventional chemotherapies. Furthermore, recent advances in nanotechnology have demonstrated encouraging results in specifically targeting CSCs, a key development considering the role of these cells in disease recurrence and resistance to treatment. Despite these breakthroughs, the clinical approval rates of nano-drugs have not kept pace with research advances, pointing to existing obstacles that must be addressed. In conclusion, nanotechnology presents a novel, powerful tool in the fight against cancer, particularly in targeting the elusive and treatment-resistant CSCs. This comprehensive review delves into the intricacies of nanotherapy, explicitly targeting cancer stem cells, their markers, and associated signaling pathways.</p><h2>Other Information</h2> <p> Published in: European Journal of Pharmaceutical Sciences<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ejps.2023.106586" target="_blank">https://dx.doi.org/10.1016/j.ejps.2023.106586</a></p>2023-12-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.ejps.2023.106586https://figshare.com/articles/journal_contribution/Shrinking_the_battlefield_in_cancer_therapy_Nanotechnology_against_cancer_stem_cells/25038497CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/250384972023-12-01T00:00:00Z |
| spellingShingle | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells Queenie Fernandes (14557388) Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Nanotechnology Nanotherapy Cancer stem cells Signaling pathways Pharmacokinetics Drug resistance |
| status_str | publishedVersion |
| title | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| title_full | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| title_fullStr | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| title_full_unstemmed | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| title_short | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| title_sort | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| topic | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Nanotechnology Nanotherapy Cancer stem cells Signaling pathways Pharmacokinetics Drug resistance |