CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

<p>Triple-negative breast cancer (TNBC), which lacks estrogen receptor α (ERα), progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression, is closely related to basal-like breast cancer. Previously, we and others report that cyclin E/cyclin-dependent kinase 2 (CDK2)...

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Main Author: Lei Nie (556344) (author)
Other Authors: Yongkun Wei (9694532) (author), Fei Zhang (85787) (author), Yi-Hsin Hsu (14917341) (author), Li-Chuan Chan (14917344) (author), Weiya Xia (454357) (author), Baozhen Ke (18614872) (author), Cihui Zhu (14894885) (author), Rong Deng (137189) (author), Jun Tang (32983) (author), Jun Yao (9646) (author), Yu-Yi Chu (636524) (author), Xixi Zhao (4251673) (author), Ye Han (261096) (author), Junwei Hou (2793103) (author), Longfei Huo (361824) (author), How-Wen Ko (10852734) (author), Wan-Chi Lin (313304) (author), Hirohito Yamaguchi (14884460) (author), Jung-Mao Hsu (14889527) (author), Yi Yang (116183) (author), Dean N. Pan (18208070) (author), Jennifer L. Hsu (245027) (author), Celina G. Kleer (14683138) (author), Nancy E. Davidson (463811) (author), Gabriel N. Hortobagyi (14888835) (author), Mien-Chie Hung (102628) (author)
Published: 2019
Subjects:
Biomedical and clinical sciences
Clinical sciences
Oncology and carcinogenesis
Triple-negative breast cancer (TNBC)
Estrogen receptor α (ERα)
Progesterone receptor
Human epidermal growth factor receptor 2 (HER2)
Basal-like breast cancer
Cyclin E
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